PubMed Health⌕ Search

Biomedical subjects

K Trautner

Publications and source records attributed to K Trautner.

At least 19 recordsLinked to original sources
PubMed1989

Influence of milk and food on fluoride bioavailability from NaF and Na2FPO3 in man.

Aqueous solutions of NaF and sodium monofluorophosphate (MFP) were given to fasting young adults in an intra-individual cross-over study. Plasma fluoride (F) levels were measured by use of a F-ion-sensitive electrode, and eight-hour profiles of F concentrations in plasma were determined. F availability and pharmacokinetic data were identical for both substances. Furthermore, the same subjects were given tablets containing 2 mg F, either as NaF or as MFP, under different experimental regimens: (a) on a fasting stomach, (b) together with milk, or (c) together with breakfast and milk. Equal F availabilities were observed for both substances. Plasma peak levels were reduced when the tablets were taken together with food. Intake of milk reduced F availability by 30% compared with the fasting stomach experiment; this effect was abolished when milk was taken as part of the breakfast. It is suggested that formation of Ca salts and entrapment of F in coagulation products of milk are important factors causing reduction of F availability, and that prolonged stay of the chyme after concomitant ingestion of food allows F to become liberated from bound forms and coagulation products by digestion processes.

Adolescent↗
PubMed1989

[Effect of food on fluoride bioavailability].

The bioavailability of fluoride (F) is not known to be reduced by any food except for milk and milk products. Their effect on F bioavailability can, however, be reduced or altogether abolished by the ingestion of solid food. Solid food intake also enhances the extraction of F from poorly soluble compounds like CaF2. The reduction of F availability by milk is thought to be attributable to binding of F as milk curdles in the stomach. Improved utilization of F by solid food intake may be explained by the prolonged retention of the chyme in the upper gastrointestinal tract, which would leave more time for F to be released from curdling products and bound forms as e.g. CaF2. Simultaneous intake of F and food produces lower serum F levels; these are, however, sustained longer than in fasted subjects. The lower peak levels may well reduce the risk of enamel mottling, while the prolonged serum F levels may produce sustained F concentrations in the oral cavity by salivary F erection. These would prevent caries.

Animals↗
PubMed1989

Influence of food on relative bioavailability of fluoride in man from Na2FPO3-containing tablets for the treatment of osteoporosis.

Aqueous solutions of NaF and sodium monofluorophosphate (Na2FPO3, MFP) and tablets containing MFP (Caflu, Tridin) were given as single oral doses to fasting healthy volunteers in an intra-individual crossover study. Serum fluoride (F) levels and urinary F concentrations were measured using an F-ion-sensitive electrode; 8 h profiles of F concentrations in serum and 24 h urinary F output were determined. F availability and pharmacokinetic data were identical for all items. In a second group of experiments, the subjects were given Caflu tablets under different experimental regimens: a) on a fasting stomach, b) together with breakfast, c) together with milk, d) together with breakfast and milk. Serum peak levels were reduced when the tablets were taken together with food. Intake together with breakfast did not affect F bioavailability, whereas milk reduced F availability by 28% compared with the fasting stomach experiment. This effect was partly abolished when milk was taken as part of the breakfast. It is suggested that entrapment of F in coagulation products of milk and formation of Ca-salts are important factors causing reduction of F availability, and that prolonged stay of the chyme after concomitant ingestion of food allows F to become liberated from bound forms and coagulation products by digestive processes.

Adult↗
PubMed1988

Human plasma fluoride levels following intake of dentifrices containing aminefluoride or monofluorophosphate.

After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma were determined in healthy human volunteers. Bioavailability of F from four dentifrices with either aminefluoride (AMF) or monofluorophosphate (MFP) was compared with that of NaF. There were no significant differences with respect to F availabilities, plasma F peak levels and plasma F profiles between NaF and the dentifrices tested, regardless of the F compound, F content or further ingredients. From the pharmacokinetic data it is concluded that dentifrices with 0.02 per cent F or less markedly decrease the risk of inducing plasma F concentrations that might disturb enamel mineralization, even if large quantities of dentifrice are ingested by small children.

Adolescent↗
PubMed1987

Factors influencing the bioavailability of fluoride from calcium-rich, health-food products and CaF2 in man.

After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma were determined in healthy human volunteers. Bioavailability of F from bone-meal, calcium and CaF2 tablets was evaluated in relation to that of NaF. Tablets were administered either whole or as a finely-ground powder, either to fasting subjects or with breakfast. Availability was lowest from whole tablets taken by fasting subjects, and highest from powdered substances given with breakfast. Mean F availabilities ranged between 7.2 and 39 per cent with bone-meal tablets, between 20 and 59 per cent with Ca tablets, and between 0 and 47 per cent with CaF2 tablets.

Adolescent↗
PubMed1986

An experimental study of bio-availability of fluoride from dietary sources in man.

After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma and saliva, and 24 h urinary excretions were determined in healthy adult volunteers. Bio-availability of F from dietary sources was evaluated in relation to that of NaF. Between 2 and 10 mg of F administered all 3 variables were dose-dependent. However, digestion, the chemical state of F, and interaction with accompanying foods may modify the kinetics of F passage through the human body. Low bio-availabilities were observed for most solid foods such as fish and algal flour and for mammalian and fish bones, when used as typical components of fluoride-rich foods such as meat- and fish-products. This data is important in the determination of optimum levels of F supplementation in human nutrition for caries-prevention programmes.

Adult↗
PubMed1985

Fluoride content of selected human food, pet food and related materials.

A survey was made of the fluoride content of selected human foods, some animal feeds, and related materials, with the purpose of a better characterization of products whose fluoride may contribute to the intake of fluoride by man as well as by some kinds of animals. Uptake of fluoride, especially from food with or without a foregoing food chain, was found to be more widely spread than has been documented previously. The major source of fluoride is represented by marine organisms, regardless of the ways by which man or animals are exposed to fluoride. As a consequence of the detailed analytical data given, recommendations would extend towards i) a more wide-spread analytical control of foods and feeds for fluoride, ii) an intensified assessment of fluoride bioavailabilities from foods and feeds, and iii) the consideration of such data in the evaluation of fluoride supplementations for optimized intakes, as recommended.

Animal Feed↗
PubMed1982

A comparative study of extracellular glucanhydrolase and glucosyltransferase enzyme activities of five different serotypes of oral Streptococcus mutans.

The activities of glucanhydrolase (EC 3.2.1.11) and glucosyltransferase (EC 2.4.1.5) in crude enzyme preparations of 44 strains of Streptococcus mutans of five serotypes were investigated. The strains were grown in a laboratory fermentor for 16 h and the enzymes were isolated by adding solid ammonium sulphate to the culture supernatant, resulting in a 12-fold enrichment of the enzymes. For glucanhydrolase, strains of serotype a showed the lowest total activity (0.768 U, approx. 120 ml), whereas strains of serotype d had an activity 39 times higher (29.9 U). The total activities of strains of serotypes b, c and e were 5.56, 6.30 and 7.06 U, respectively. For glucosyltransferase, strains of type e showed the highest total activity (293 U), whereas differences between strains of the other four types were insignificant (type a: 158 U; type b: 175 U; type c: 191 U; type d: 225 U; approx. 120 ml). A strong correlation was found between the glucanhydrolase activity and the percentage of insoluble glucan synthesized in vitro by the respective strains. This correlation was not substantially changed if the enzyme activities were expressed as specific activities, or as total activities against bacterial weight.

Dextranase↗
PubMed1981

The evaluation of a new enzyme immunoassay for the measurement of prostatic acid phosphatase.

An enzyme immunoassay for prostatic acid phosphatase (PAP) has been assessed. An upper limit normal is set at 1.8 microgram/1. There is a very low incidence of raised levels in chronic diseases or cancers other than those of the prostate. Patients with well-controlled prostatic cancer have levels less than 1.8 microgram/1 and show little variation about their own mean. PAP can rise exponentially with a doubling time of 1-5 months. This assay is unlikely to increase the detection of asymptomatic prostatic cancer as 66% of T0-2NXM0 cases had PAP less than 1.8 microgram/1. The main advantages over routine enzyme assays are its sensitivity and accuracy in the lower range.

Acid Phosphatase↗