PubMed Health⌕ Search

Biomedical subjects

K Umeyama

Publications and source records attributed to K Umeyama.

At least 73 records · Page 4Linked to original sources
PubMed1988

[A case of plasmacytoma (IgD lambda) of the breast associated with multiple myeloma].

A case of secondary plasmacytoma (Ig. D. lambda) of the breast, associated with multiple myeloma, is reported, involving a 60-year-old woman in whom multiple tumors of the right breast appeared during the course of her treatment for multiple myeloma. These breast tumors were firm, non-tender, clear-margined, smooth-surfaced, and showed good mobility. An ultrasonogram revealed that the tumors had the shape of a clear-margined anechoic mass like a cyst. A histological diagnosis of a biopsied specimen determined plasmacytoma (Ig. D, lambda) and the patient was treated with chemotherapy which caused the tumors to greatly reduce.

Breast↗
PubMed1988

[Postoperative total parenteral nutrition with fat emulsion for patients with esophageal varices].

The administration of fat emulsion and total parenteral nutrition (TPN) was evaluated in 68 patients with liver disorders who underwent surgical treatment for esophageal varices. The subjects were divided into two groups, fat group (28 cases) and non-fat group (40 cases) according to with or without the administration of fat emulsion during the period of postoperative TPN. The results of liver function tests, blood glucose levels, intravenous fat tolerance tests, serum lipid levels, fatty acid composition in serum total lipids, nitrogen balances and body weight changes during the period of postoperative TPN were compared between both groups. Conclusions as follows; 1. The administration of fat emulsion during the period of postoperative TPN did not worsen the results of liver function tests, and relatively low levels of blood glucose were retained. 2. The removal rates of fat emulsion from the blood (K2 values) during the period of postoperative TPN were significantly higher than in those preoperative period, and changes in serum lipid level revealed no tendency toward retention of fat emulsion administered intravenously. 3. Cumulative nitrogen balance were almost similar in both groups. 4. The administration of fat emulsion the period of during postoperative TPN corrected the abnormalities of fatty acid composition in serum total lipid. Further, it was suggested that approximately more than 5 ml/kg/day of 10% fat emulsion would be advisable to prevent the decrease of linoleic acid. 5. These results suggested that the administration of fat emulsion was useful for the patients with esophageal varices during the period of postoperative TPN.

Adult↗
PubMed1988

[Results of long follow-up study for peptic ulcer patients treated with gastrectomy].

This clinical study was based on 307 peptic ulcer patients treated with gastrectomy over a 15-year period in our department. Numbers of surgical cases for peptic ulcer remarkably decreased after the introduction of cimetidine in 1980. A median age of gastric ulcer patients was in sixth decades, whereas duodenal ulcer in fifth decades. Surgical indications were 60 percent in intractable ulcer, 30 percent in complication as bleeding, stenosis and perforation, and 10 percent in suspicious malignancy. After cimetidine introduction intractable cases decreased from 63 percent to 44 percent. There was no remarkable difference in the fasting and peak plasma secretin concentrations in postprandial period between peptic ulcer patients and normal controls, however, in gastrectomized patients the plasma secretin response decreased in postprandial state. Follow up study was made on a point of postoperative recurrence and postgastrectomy syndrome. Small stomach syndromes such as insufficient food intake and body weight loss were observed in 10 and 30 percent in the gastrectomized patients, but 86 percent of the patients were satisfied with the results of operation. We concluded that gastrectomy for peptic ulcer was treatment of choice from the point of low recurrence rate and no severe postgastrectomy disorders.

Adult↗
PubMed1988

[Renal microcirculation in experimental acute pancreatitis of dogs--the effect of pancreatic protease inhibitor and dopamine].

To understand the renal microcirculation in acute pancreatitis is important to know the pathophysiology of renal insufficiency frequently observed as one of multiple organ failures in severe acute pancreatitis. In mongrel dogs acute pancreatitis was experimentally introduced by autologous bile added trypsin injection into the pancreatic duct. The effect of new synthesized pancreatic protease inhibitor (PATM) and dopamine in a dose of 3mg/kg/hr and 10 micrograms/kg/min were investigated, respectively. In acute pancreatitis dogs, renal arterial blood flow and renal tissue blood flow immediately fell and gradually decreased in time course of experiment and renal vascular resistance increased from 2 hours after onset of pancreatitis. When pancreatic protease inhibitor (PATM) was infused in acute pancreatitis dogs, blood pressure and pulse pressure relatively preserved during the experiment. Renal blood flow and renal tissue blood flow were maintained during the first 1 hour and thereafter slightly decreased, however which was less than that of no PATM treated dogs. When dopamine was infused in acute pancreatitis dogs, blood pressure was maintained during the first 90 minutes thereafter remarkably decreased. Renal blood flow was maintained within 60 minutes, however it remarkably decreased at the end of the experiment. This study suggested that renal microcirculation was disturbed from early period of acute pancreatitis in dogs and pancreatic protease inhibitor (PATM) had a beneficial effect of maintain the renal microcirculation.

Acute Disease↗
PubMed1988

[Pancreatic microcirculation in acute pancreatitis of dogs].

Pancreatic microcirculation in acute pancreatitis and the effect of dopamine and pancreatic protease inhibitor were investigated in 35 mongrel dogs. Acute pancreatitis was induced by the injection of autologous bile added trypsin into pancreatic duct. In acute pancreatitis dogs femoral artery pressure and pulse pressure gradually decreased and pancreatic microflow in basal state temporarily increased immediately after bile injection, however, thereafter continuously decreased during the experiments. Portal flow severely decreased just after onset of acute pancreatitis. By administration of dopamine femoral artery pressure was maintained during the first 90 minutes of experiments, however, thereafter decreased until the end of experiments. Pancreatic microflow, 56.1 +/- 15.3 ml/min/100g in basal level was shown 66.1 +/- 13.7 and 60.3 +/- 10.3 ml/min/100g at 1 and 2 hours, respectively, after bile injection, which were significantly high values as compared with those of non dopamine administration. However those values decreased at 5 hours of both experiments. Portal flow whose basal level was 237 +/- 67 ml/min was maintained during the first 1 hour however it decreased to 139 +/- 25 ml/min at 5 hours. By administration of pancreatic protease inhibitor femoral artery pressure and pulse pressure, temporarily decreased immediately after bile injection, however, they were maintained thereafter. Pancreatic microflow, 57.1 +/- 18.3 ml/min/100g in basal level, was maintained during the first 2 hours, however significantly decreased to 27.6 +/- 9.7 ml/min/100g at 5 hours. Portal flow significantly increased to 442 +/- 115 ml/min at 2 hours, however, thereafter decreased 219 +/- 93 ml/min at 5 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1988

Primary carcinoma of the gallbladder.

Forty four patients with primary carcinoma of the gallbladder diagnosed during 12 years were reviewed. Nineteen patients had histologically proven cancer and the remaining 25 patients were diagnosed by laparotomy and/or the several diagnostic procedures. The female to male ratio was 1.6 to 1. The mean age was 65.7 years in resected cases and 63.5 years in unresected cases. The mean survival times in curative, noncurative resection and unresected cases were 49.8, 7.9 and 2.9 months, respectively. Although early diagnosis is difficult due to the lack of specific symptoms and signs, our results suggested that the measurement of serum CA 19-9 is a useful marker for detection and ultrasonography is helpful in the early assessment of disease. These tests, together with more aggressive surgery, may extend the survival of patients with primary carcinoma of the gallbladder.

Aged↗
PubMed1987

The detection of human pancreatic cancer-associated antigen in the serum of cancer patients.

A radioimmunoassay (RIA) test for human pancreatic cancer-associated antigen (Span-1) was developed to evaluate the diagnosis of various gastrointestinal disorders. Serum Span-1 in normal subjects ranged from 5 to 275 U/ml, with a mean of 58.8 U/ml (+/- 58.7, standard deviation). All control subjects had levels of less than 400 U/ml. Study subjects, 93% with pancreatic cancer, 59% with hepatobiliary cancers, 23% with gastric cancers, and 13% with colonic cancers had serum Span-1 levels greater than 400 U/ml. Sensitivities of Span-1, CA 19-9, and Dupan-2 for pancreatic cancer were 94%, 85%, and 38% respectively. Span-1 in patients with Stage I pancreatic cancer showed a 50% positive rating but CA 19-9 and Dupan-2 showed only 0% and 25%. Although a positive rating of these three antibodies increased in advanced cases, Span-1 showed the highest positive rating. Span-1 reacted with colonic cancer tissues with Lewisa-b- phenotype. However, none of these tissues did not react against CA 19-9. From these results, Span-1 has a good predictive value for detecting pancreatic cancer compared with CA 19-9 and Dupan-2.

Antibodies, Monoclonal↗
PubMed1987

A comparative study of experimental and human pancreatic carcinoma with special reference to histochemical findings.

This study was undertaken in order to histochemically investigate the mucoid substances (acid mucopolysaccharide and sialic acid) in experimental and human pancreatic carcinoma. The degree of alcian blue staining in the ductal and interstitial portions of the pancreas increased, especially in hamster tubular adenocarcinoma which had been induced by N-nitrobis (2-hydroxypropyl) amine. The pancreatic carcinoma of the rats, induced by di-methyl benz (alpha) anthracene, was usually poorly differentiated carcinoma, in which alcian blue and toluidine blue staining was high in the interstitial portion when compared with that of the hamster pancreatic carcinoma, which was usually well differentiated. The rates of enzyme digestion of acid mucopolysaccharide and sialic acid showed more prominently in the rat pancreatic carcinoma than in the hamster pancreatic carcinoma. Mucoid substances in the ductal portion of human pancreatic carcinoma revealed properties similar to those of hamster pancreatic carcinoma whereas those in the interstitial portion were similar to those of rat pancreatic carcinoma. These results suggested that mucoid substances, especially acid mucopolysaccharide, both in experimental and human pancreatic carcinomas, may play an important role in tumor growth.

Adenocarcinoma↗
PubMed1987

Colorectal carcinoma in young adults.

Charts of 570 patients with colorectal carcinoma surgically treated in one institution during a 13 year period were retrospectively reviewed to evaluate clinicopathologic patterns and surgical results of those 39 years of age or under. Of the 570 patients, 57 (10 percent) were 39 years of age or under, and this group included more female patients than the older control group. Mucinous carcinoma was frequently found on histologic examination, with significantly high incidences of lymph node involvement, peritoneal dissemination, and advanced tumor stages by Dukes' classification in the young patients. The overall cumulative 5 year survival rate in the younger group was significantly lower than that in the control group (41 percent and 55.9 percent, respectively), whereas the difference in rates among the two groups for curative resection was not statistically significant (71.6 percent and 76.3 percent, respectively). Early diagnosis and attempts at curative resection are of utmost importance in the treatment of young patients with colorectal carcinoma.

Adenocarcinoma↗
PubMed1987

A serial histologic study of the healing process after relapsing edematous acute pancreatitis in the rat.

This study was undertaken to investigate the serial histologic factors of the healing process in the rat after relapsing edematous acute pancreatitis induced by the closed duodenal loop. Serum amylase levels in single, second and third attacks of edematous acute pancreatitis were elevated significantly compared with those in the control group (p less than 0.01), but the concentrations were similar in the three groups and it returned to normal by the seventh day after the attack. However, the histologic finding was different. The histologic factors of the pancreas on the first day after the first attack showed interstitial edema and a mild inflammatory cell infiltration which returned to normal on the seventh day. Histologic findings on the first day of the second attack showed the same histologic changes with mild degenerative changes and partial degenerative atrophy of the acinar cells. On the seventh day after the attack, partial degenerative atrophy of the acinar cells, proliferation of the small duct and slight interstitial fibrosis remained but returned to normal one month later. On the first day after the third attack, histologic findings showed more obvious changes compared with the first and second attacks. There was much diffuse interstitial edema, a heavy inflammatory cell infiltration and massive necrosis of the acinar cells. One month later, a diffuse marked fibrosis in the interstitial space and intralobular tissue associated with small duct proliferation remained. The results indicate that repeated attacks of edematous acute pancreatitis may lead to more chronic pancreatic damage.

Acute Disease↗
PubMed1987

[A case of a carcinoid of the duodenum (somatostatin-, serotonin- and ACTH-producing) with carcinoma of the stomach].

A case of a duodenal carcinoid which was producing somatostatin, serotonin and ACTH in a 65-year-old man is reported. The patient was found to have a submucosal protruded mass of the duodenal bulb and a tumor mass-like IIa + IIc in the antral portion of the stomach. Subtotal gastrectomy was performed and the histological diagnosis of the tumors were found to be a classical carcinoid of the duodenum and a well-differentiated tubular adenocarcinoma of the stomach. The carcinoid cells of the duodenum had numerous cyto-plasmic granules which were positive by Grimelius staining and negative by Hellerström-Hellmann staining, and 200-300 nm in size, electronmicroscopically. These cells were shown to contain somatostatin, serotonin or ACTH-positive cells by means of monoclonal immunohistochemistry, however, results were negative for gastrin, insulin, glucagon, calcitonin, VIP or PP.

Adenocarcinoma↗
PubMed1987

Cancer-associated alterations of blood group antigen expression in the human pancreas.

Certain alterations of blood group substance (BGS) expression have been observed in gastrointestinal cancer tissues. However, in the pancreas little is known about BGS expression by normal or malignant tissue. The present immunohistochemical study analyzed simultaneously the expression of A, B, H, Lewisa (Lea), and Lewisb (Leb) antigens in specimens of normal pancreas, chronic pancreatitis, and pancreatic carcinoma (primary and metastatic). In normal pancreas all five antigens were expressed in ducts, ductules, and acini, but not in islets. Acinar cells expressed A, B, H, and Leb in supranuclear cytoplasm, whereas Lea was found mainly on centroacinar cells. Only BGSs that were appropriate for the host's blood type were expressed, except for one case of Lea deletion. BGS expression by chronic pancreatitis tissue closely resembled that by normal tissue. In primary pancreatic cancer two cancer-associated alterations were noted that were not found in either normal pancreas or chronic pancreatitis. Deletion of an expected A, B, H, or Leb antigen occurred in approximately 25% of cases, particularly in more poorly differentiated cancers. Incompatible expression of an unexpected A or B antigen occurred in 33% of cases, regardless of degree of differentiation. Metastatic pancreatic cancers also exhibited BGS deletion and incompatibility. In both primary and metastatic cancers the incidence of incompatible A or B expression was higher in cancers from the United States than in cancers from Japan, but the incidence of BGS deletion was similar between the two countries. It was concluded that deletion of A, B, H, or Leb antigens and incompatible expression of A or B antigens are cancer-associated events in the pancreas.

ABO Blood-Group System↗
PubMed1987

[A case of amebic liver abscess rupturing into the stomach].

A forty-eight year-old man complained of upper abdominal pain and diarrhea with mucinous bloody stool. He had not been abroad. Except high fever, anemia, leukocytosis and elevated rate of erythrocyte sedimentation, laboratory findings were not abnormal. Gastrofiberscopy showed the protrusion of gastric mucosa with a hollow on its surface in the angle. Abdominal CT scan and echogram revealed an abscess in the right hepatic lobe and an abscess in the left lobe. Ulceration and small protrusion of the rectal mucosa were found by romanoscopy. Stool examinations could not reveal amebas, but serological test for amebiasis by the Ouchterlony method showed positive. Under the diagnosis of the perforation into the stomach of amebic liver abscess, he was treated with Metronidazole and tetracycline. But, as a diffuse shadow appeared in the right thoracic cavity on the chest x-ray films with bloody sputa, perforation of amebic liver abscess to the right thoracic cavity was suspected. Laparotomy showed the communication of the abscess to gastric lumen. The post operative course was uneventful. We reported a case with the rare complication of amebic liver abscess.

Humans↗
PubMed1987

An experimental study of a splenic inhibitory factor influencing hepatic regeneration.

The effect of splenectomy on hepatic regeneration after 70 per cent partial hepatectomy was studied in rats. Compared with nonsplenectomized rats, preliminarily splenectomized rats showed significantly increased weights of the liver in the early stage (up to four days) after hepatectomy and significantly promoted deoxyribonucleic acid synthesis in the regenerating liver in terms of high levels of 3H-thymidine uptake, thymidine kinase activity and mitotic index in the residual liver 24 hours after hepatectomy. The splenic factor inhibiting hepatic regeneration, as previously suggested, was investigated by using primary cultures of rat hepatocytes. At 48 hours when the 3H-thymidine uptake by cultured hepatocytes reached maximum, the group containing a splenic extract showed significantly lower levels (p less than 0.005) of uptake than did the group without the extract and the group containing splenic venous serum also showed lower levels. This splenic factor was labile against heat and lost activity by trypsinization. Furthermore, gel filtration by the use of Sephadex G-75 column suggested the factor to be a protein-like substance with a molecular weight of 50,000 to 60,000. It is likely that a protein-like substance inhibiting hepatic regeneration after hepatectomy is present in the spleen.

Animals↗