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Biomedical subjects

K V Bunin

Publications and source records attributed to K V Bunin.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Comparative evaluation of the functional activity of different immunoglobulin classes in cholera].

The immunological activity of specific immunoglobulins in different forms of cholera infection was studied with the use of the indirect immunofluorescent method. The forms of cholera infection were shown to be related to the physico-chemical spectrum of antibodies: patients with the pronounced clinical symptoms of cholera produced serum IgM, including antigen -- antibody complex, more actively and in a greater amount; patients with faintly pronounced and asymptomatic infection produce highly active IgG. The competitive action of immunoglobulins of different classes in their simultaneous reaction with O antigen of Vibrio cholerae is shown. The mechanism of the competitive action of different immunoglobulin classes is supposed to play some role in the process of the sanation (with highly active IgM) or detoxication (with highly active IgG) of the organism.

Antigen-Antibody Complex↗
PubMed1978

[Assessment of the degree of antibody avidity in food toxinfections of salmonellal etiology using the indirect hemagglutination inhibition reaction].

The authors studied the avidity of antibodies in the sera obtained from 56 patients suffering from salmonelloses, the causative agents of which were referred to groups B, C1, C2, E. Determinations were carried out in the indirect hemagglutination inhibition test. It was shown that the mentioned test could be used to assess the extent of the serum antibodies avidity. Age-specific avidities of the serum antibodies were revealed in patients suffering from salmonella infections during the infectious process. There was found an insignificant prevalance of the antibody avidity in the patients with the forms of the disease of moderate severity and severe. In the patients with salmonelloses of group B the antibodies proved to be the most avid.

Antibodies, Bacterial↗
PubMed1978

[The choice of optimal sensitizing dose of the antigen in the preparation of cholera erythrocytic diagnostic agent, with consideration to the avidity of antibodies under study].

The authors studied the comparative antigenic activity in the indirect hemagglutination test (IHAT) of erythrocytic diagnostic agents sensitized with various doses of cholera O-antigen. A definite dependence of the IHAT results on the avidity degree of the antibodies determined in the serum was demonstrated. To ascertain the maximal levels of highly avid antibodies (in the hyperimmune cholera sera) it is possible to use antigen doses exceeding the optimal sensitizing ones. In examination of less avid antibodies (for example in the blood sera of cholera patients) the diagnostic agent in such doses displayed decreased IHAT titres. To increase the reliability of the IHAT results it is recommended to choose the sensitizing antigen doses for the preparation of the diagnostic agent to be used in the IHAT with consideration to the avidity of antibodies examined in the blood sera.

Antibodies, Bacterial↗