Biomedical subjects

K V R Murthy

Publications and source records attributed to K V R Murthy.

4 recordsLinked to original sources

PubMed2006

Thermoluminescence dosimetric characteristics of beta irradiated salt.

The thermoluminescence (TL) characteristics of sodium chloride (NaCl), known as common salt, used for cooking purposes (iodised salt), have been studied in the present paper considering its usage as an 'accidental dosemeter' in the case of a nuclear fallout. TL characteristics of common salt have been examined under excitation with a beta dose of 20 Gy from a 90Sr beta source. The salt specimens are used in the form of discs. The average salt grain that sticks to the disc is measured to be approximately 1 mg. The TL of the beta irradiated salt is recorded in the conventional TL apparatus. Initially three peaks were observed at 133, 205 and 238 degrees C. All three peaks are well resolved, having maximum intensity at 238 degrees C. The material under investigation, i.e. 'common salt' possesses many good dosimetric properties and therefore this can be considered as an 'accidental dosemeter'.

Beta Particles↗

PubMed2006

Compact fluorescent lamp phosphors in accidental radiation monitoring.

The application of lamp phosphors for accidental dosimetry is a new concept. Since the materials used in fluorescent lamps are good photo luminescent materials, if one can either use the inherent defects present in the phosphor or add suitable modifiers to induce thermoluminescence (TL) in these phosphors, then the device (fluorescent lamp) can be used as an accidental dosemeter. In continuation of our search for a suitable phosphor material, which can serve both as an efficient lamp phosphor and as a good radiation monitoring device, detailed examination has been carried out on cerium and terbium-doped lanthanum phosphate material. A (90)Sr beta source with 50 mCi strength (1.85 GBq) was used as the irradiation source for TL studies. The TL response as a function of dose received was examined for all phosphors used and it was observed that the intensity of the TL peak vs. dose received was a linear function in the dose range 0.1-200 Gy in each case. Incidentally LaPO(4): Ce,Tb is a component of the compact fluorescent lamp marketed recently as an energy bright light source. Besides having very good luminescence efficiency, good dosimetric properties of these phosphors render them useful for their use in accidental dosimetry also.

Beta Particles↗

PubMed2004

Physicochemical characterization and dissolution properties of meloxicam-cyclodextrin binary systems.

The objective of the work is physicochemical characterization of meloxicam (ME)-cyclodextrin (CD) binary systems both in solution and solid states and to improve the dissolution properties of meloxicam via complexation with alpha-, beta- and gamma-cyclodextrins. Detection of inclusion complexation was done in solution state by means of phase solubility analysis, mass spectrometry and 1H nuclear magnetic resonance (NMR) studies, and in solid state using differential scanning calorimetry (DSC), powder X-ray diffractometry, and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H NMR studies in solution state revealed 1:1M complexation of meloxicam with all CDs. A true inclusion of ME with gamma-CD at 1:1 and 1:2M in solid state was confirmed by DSC, powder XRD and scanning electron microscopy (SEM) studies. Dissolution properties of ME-CDs binary systems were superior when compared to pure ME.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMed2003

Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems.

The objective of this work is physicochemical characterization of nimesulide-cyclodextrin binary systems both in solution and solid state and to improve the dissolution properties of nimesulide (N) via complexation with alpha-, beta, and gamma-cyclodextrins (CDs). Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1H nuclear magnetic resonance (1H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H-NMR studies in solution revealed 1:1 M complexation of N with all CDs. A true inclusion of N with beta-CD at 1:2 M in solid state was confirmed by DSC, powder X-RD and SEM studies. Dissolution properties of N-CD binary systems were superior when compared to pure N.

Anti-Inflammatory Agents, Non-Steroidal↗