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Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems.

Buchi N Nalluri·K P R Chowdary·K V R Murthy·A R Hayman·G Becket
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Abstract

The objective of this work is physicochemical characterization of nimesulide-cyclodextrin binary systems both in solution and solid state and to improve the dissolution properties of nimesulide (N) via complexation with alpha-, beta, and gamma-cyclodextrins (CDs). Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1H nuclear magnetic resonance (1H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H-NMR studies in solution revealed 1:1 M complexation of N with all CDs. A true inclusion of N with beta-CD at 1:2 M in solid state was confirmed by DSC, powder X-RD and SEM studies. Dissolution properties of N-CD binary systems were superior when compared to pure N.

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Anti-Inflammatory Agents, Non-SteroidalCalorimetry, Differential ScanningCyclodextrinsMacromolecular SubstancesMagnetic Resonance SpectroscopyMass SpectrometryMicroscopy, Electron, ScanningSolubilitySulfonamidesX-Ray DiffractionJournal Article

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Buchi N Nalluri, K P R Chowdary, K V R Murthy, A R Hayman, G Becket. 2003. Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems.. https://doi.org/10.1208/pt040102

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