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Biomedical subjects

K Woźniak

Publications and source records attributed to K Woźniak.

At least 37 records · Page 2Linked to original sources
PubMed2000

[Developmental abnormalities of mineralization in populations with varying exposure to fluorine compounds].

The aim of the study was to determine the influence of environmental factors on developmental defects of dental enamel. The examination was carried out in a group of 238 schoolchildren (group I) aged 14 to 15 years, living since birth in a region with elevated levels of chemical compounds (fluorine, ammonia, sulphur) in the atmosphere. The control group (group II) consisted of 240 schoolchildren of the same age, living in regions with normal atmospheric concentrations of these compounds. The Epidemiological Index of Developmental Defects of Dental Enamel (DDE Index), Dean fluorosis index, and DMF index were used in the clinical examination. Additionally, a questionnaire was given to parents of the examined children. It was found that the number of children and teeth with developmental defects of dental enamel was greater in group I. Significant differences between boys and girls were noticed. The most common developmental defect of dental enamel in both groups was white/creamy opacity. The next common defect was hypoplasia. The incidence of diffuse white/creamy mottling and lines was higher in the study group than in controls. This was the basic finding which differentiated the two populations studied. Both groups differed as to the Dean index. Nevertheless, a comparison of Dean and DDE indices led to inconsistent conclusions. The distribution of developmental defects of dental enamel was similar in both groups. The defects were most often found on the buccal surfaces of maxillary premolars and maxillary central incisors. Children with developmental defects of dental enamel had a significantly higher incidence of caries and elevated mean DMF, as compared to children without any abnormalities of mineralization. Similar correlations were not found in the control group. The questionnaire revealed a positive correlation between the education level of parents, standards of living, and of abnormalities mineralization in both groups of children.

Adolescent↗
PubMed1996

[Molecular effects of chromium compound activity].

Chromium(VI) compounds produce a variety of DNA damage such as DNA single strand breaks, alkali-labile sites and DNA-protein cross-links in vivo and in cultured cells. Chromium(III) compounds bound to isolated DNA and proteins. Cr(VI) readily entered cell through general anion channels. In contrast, Cr(III) did not readily cross cell membranes. Inside cells Cr(VI) is reduced through intermediates to Cr(III) by cellular reductants. Reactive intermediates formed during intracellular Cr(VI) reduction might be responsible for some chromate genotoxicity. Ascorbic acid decreases chromate induced alkali-labile sites and chromium inhibition of glutathione reductase, but it enhances DNA-protein cross-links and cytotoxicity caused by this metal.

Animals↗
PubMed1995

14N nuclear quadrupole resonance studies of 1,8-bis(dimethylamino)naphthalene.

The presence of four resonance peaks from two nitrogen atoms in the 14N nuclear quadrupole resonance (NQR) spectrum of 1,8-bis(dimethylamino)naphthalene (DMAN) confirms the asymmetry of this molecule in the crystal. Spectroscopic parameters such as transition frequencies as well as the asymmetry parameters of the electric field gradient (EFG) tensors and differences in sigma bond occupation numbers have been assigned to particular nitrogen atoms in the molecule.

Magnetic Resonance Spectroscopy↗
PubMed1993

Ab initio calculations of the 1H and 14N NMR shielding constants in solid ammonia.

The gauge-independent atomic orbital (GIAO) approach is used within the coupled Hartree-Fock (CHF) approximation to compute the 1H and 14N NMR shielding constants in solid ammonia. A comparison with gaseous NH3 shows that (a) both shielding constants are decreased to values belonging to the liquid state and (b) anisotropies of the two shielding constants are changing in opposite directions, i.e. a decrease for the nitrogen nucleus and an increase, smaller than the decrease, for the protons are observed.

Ammonia↗
PubMed1991

Cardiovascular diseases risk factors in male population from mining vocational schools of the Lublin Coal Basin.

Contrary to certain industrial countries which secure an impressive decrease in coronary heart mortality, Poland has had, especially in the last decade, the significant increase of morbidity and mortality caused by cardiovascular diseases. Although this phenomenon concerns mainly the middle-age mean groups, special care for the whole population should be undertaken. The successful way to decrease the death rate and morbidity attributed to coronary heart disease (CHD) are the long-term prevention programs as for example Multiple Risk Factor Intervention Trial, Belgian Heart Disease Prevention Project, Lipid Research Clinics Coronary Primary Prevention Trial and others. Because there is some evidence that certain risk factors occur also among children, it seems that the effectiveness and efficacy of such prevention programs may be increased when started in the young population.

Adolescent↗
PubMed1991

Evaluation of nutritional status of male population from mining vocational schools in the Lublin coal basin.

The basic nutritional mistake in Polish population at considerably rare deficiency of proteins and calories is incorrect composition of diet with the excess of animal fat and carbohydrates. Social and economic changes which influence living conditions result in the change of diet whose trends are not always correct. The problem is the quality of food products, contamination of pollution due to industrialization and the use of chemicals in agriculture, and inadequate proportion in the essential food components or supply of the indispensable trace elements. The other problem is overnutrition leading to obesity which is one of risk factors in civilization diseases (8, 11). The nutritional status depends on the level of education and economic situation of different social groups. It is expected that among the pupils of vocational mining schools who usually come from numerous peasant and working class families nutritional mistakes may occur very often. It denotes both malnutrition and incorrect proportion in consumption of proteins, animal fats and carbohydrates. On the other hand, the expected changes in social and economic status due to a good job create new conditions for proper nutrition. An additional factor which should be taken into account are nutritional requirements resulting from specific character of underground work.

Adolescent↗
PubMed1990

[Risk factors of coronary artery disease in males during a 3 year follow up based on a cohort study in a selected region of Lublin].

To assess changes in risk factors of coronary artery disease, examinations which had been performed in 1981 and 1982 were repeated in males aged 40-59, inhabitants of the district "Czechów" in Lublin. The study was based on Polish Experiment of Coronary Disease Multifactor Prevention assumptions 112 of 203 males investigated in 1981, 1982 underwent repeated examination (attendance rate - 55%). Statistical analysis was performed only in twice examined subjects. Significant increase of blood pressure, body weight, total serum cholesterol and uric acid concentration was stated in comparison with their respective initial values. Significant decrease of HDL-cholesterol and no changes in serum triglycerides concentration were observed. The only positive stated alteration was a lower percentage of tobacco smokers. Diagnosis of coronary artery disease remained unchanged despite of increased risk factors levels (increase of mean Rose's index score from 5 in initial examination to 6.5 in a control one). This high increase in risk factors occurrence allows an unfavourable prognosis for future incidence of coronary artery disease and also demands to undertake vigorous prevention.

Adult↗
PubMed1980

Amino acid composition of the mu chains of IgM of normal serum, monoclonal cryoglobulin and Waldenstrom macroglobulin.

The purified IgM of normal human serum, monoclonal cryoglobulin and Waldenstrom macroglobulin were reduced, alkylated and subjected to Sephadex G-100 filtration. The mu chains separated were hydrolysed and analysed for amino acid content. In both monoclonal proteins the content of hydroxyproline in mu chains was lower than in the IgM of normal serum. The mu chain of monoclonal cryoglobulin contained less serine, methionine and tyrosine, whereas mu chains of Waldenstrom macroglobulin showed a lower level of cystine as compared with the IgM of normal serum. On the other hand, the content of valine and basic amino acids was higher in both monoclonal proteins.

Amino Acids↗
PubMed1978

[Thymol test, concentration of total protein and bilirubin and activity of various serum enzymes in a population exposed to diphenylformamide].

445 workers occupationally exposed to subtoxic diphenylformamide concentration were examined. No significant differences were found in results of thymol test, concentration of total protein, bilirubin, and activity of basic phosphatase in blood serum, compared with the control group. A higher activity of asparagine--and--alanine aminotransferas and gamma--glutamylotranspeptidase was found; it was, however, statistically insignificant.

Adult↗
PubMed1976

Effect of some lipids on the activity of renin in vitro.

A partially purified bovine renin preparation and a homologous renin substrate were used to study the effect of some lipids on the amount of angiotensin formed. It was found that lecithin and the detergents used (deoxycholate and sodium dodecylate) inhibited the renin activity. Palmitic acid, oleic acid and cholesterol had no distinct effect. On the other hand, the reaction was enhanced by prostaglandins E2 and F2alpha.

Angiotensin II↗