Case reports. Tetanus following a dental operation.
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Female↗
Biomedical subjects
L A Cone
Publications and source records attributed to L A Cone.
Acquisition of antibody to hepatitis B antigen in three socioeconomically different medical populations.
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Adolescent↗
The natural history of rheumatic fever. Incurable, fatal pancarditis: forty years later.
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Adolescent↗
Malignant melanoma of the rectal ampulla: report of a case and review of the literature.
Documentation of the seventeenth case of melanoma of the rectum is presented. The world literature is reviewed. The effectiveness of immunotherapy with BCG or BCG in combination with CCNU and DTIC remains to be established.
BCG Vaccine↗
Human immunodeficiency virus type 1 antigenaemia is enhanced in patients with disseminated cytomegalovirus infection and deficient T lymphocytes.
We have studied 61 patients with the acquired immunodeficiency syndrome (AIDS) regarding the relationships between disseminated cytomegalovirus (CMV) infection with CMV retinitis, HIV1 antigenaemia and CD4+ and CD8+ T-cell deficiency. HIV1 p24 antigenaemia was present in all patients with CMV retinitis (at a high concentration), but in only 28% of patients without retinitis (at a low concentration). Compared to patients without retinitis, those patients who developed retinitis had lower CD4+ and CD8+ prior to and during AIDS. CMV may contribute to deficiencies of T lymphocytes in patients with AIDS.
Acquired Immunodeficiency Syndrome↗
Responses of neurologic complications of AIDS to 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. I. Clinical features.
Fourteen patients with AIDS were treated for 23 neurologic complications: four episodes of acute meningoencephalitis; eight episodes of subacute encephalopathy; two cases of progressive multifocal leukoencephalopathy; and nine cases of polyneuropathy. Nine patients were treated with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG), one with 3'-azido-3'-deoxythymidine (AZT), and four initially with DHPG directed against cytomegalovirus (CMV) retinitis or encephalitis and subsequently with AZT against human immunodeficiency virus (HIV) encephalopathy. CMV retinitis was a helpful clinical observation indicating neurologic involvement. DHPG produced improvement in two of three cases of acute meningoencephalitis but was ineffective in cases of subacute encephalopathy or neuropathy. AZT therapy resulted in resolution in both of the two treated cases of acute confusional state and in two of the four treated cases of polyradiculoneuropathy with paraparesis but was ineffective in the late stage of subacute encephalopathy. These results suggest that CMV is important in some cases of acute meningoencephalitis, whereas HIV is a dominant pathogen in subacute dementia and polyneuropathy in patients with AIDS. DHPG may be beneficial in the former, whereas AZT appears to be effective in the latter complications.
Acquired Immunodeficiency Syndrome↗
Aztreonam therapy for serious gram-negative bacillary infections.
Fifty episodes of gram-negative bacillary infection, including episodes of bacteremia, pneumonia, and skin and soft tissue, complicated urinary tract, and abdominal infections, were treated with aztreonam. Eighty-eight percent of patients were cured of their infection, including all nine patients with bacteremia and 15 of 17 patients with pneumonia. Thirty percent of all infections were caused by Pseudomonas, and all of these responded to treatment with aztreonam. A low incidence of toxicity and a high rate of efficacy make treatment with aztreonam as a single agent feasible. When gram-positive or anaerobic organisms were encountered or their presence in the infection was suspected, additional agents effective against these organisms were necessary for cure.
Aged↗