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Biomedical subjects

L A Romanova

Publications and source records attributed to L A Romanova.

32 records · Page 2Linked to original sources
PubMed1975

Deamination of biogenic amines and other nitrogenous compounds in granulation tissue from experimental wounds.

In the granulation tissue of skin wounds an increase in the content of hydroxyproline was accompanied by changes in lipid peroxidation products. At the same time deamination of 5-hydroxytryptamine, tyramine or adenosine-5'-monophosphate decreased, but the ability to deaminate histamine, putrescine and lysine appeared. Pargyline prevented the appearance of these new deaminating properties. Adenosine-3'-monophosphate slowed down to the weight increase and lowered the content of hydroxyproline in the growing granulation tissue; it also changed the dynamics of deamination of tyramine or 5-hydroxytryptamine and significantly inhibited the deamination of histamine, lysine and adenosine-5'-monophosphate. The patterns of changes in deamination of nitrogenous compounds and the effects caused by pargyline and adenosine-3'-monophosphate suggest that qualitative alteration (transformation) in catalytic properties of monoamine oxidases may occur in the growing granulation tissue from wounds.

Adenosine Monophosphate↗
PubMedDate not supplied

[Anemia syndrome in patients with chronic renal insufficiency on peritoneal dialysis treated with recombinant erythropoietin].

The paper presents the results of the studies of erythrocytic and iron metabolism parameters in the course of treatment with recombinant erythropoietin (RE) and iron preparations in 60 patients with chronic renal failure (CRF) on peritoneal dialysis (PD) aged 20 to 75 years. Pretreatment iron deficiency in CRF patients on PD persisted to the end of the third observation period. Hyperferritinemia registered in CRF patients on PD with frequent peritonitis may be considered as a result of active ferritin synthesis by the cells of the system of mononuclear phagocytes in response to inflammation. The only parameter indicating the presence of iron deficiency seems to be the percentage of hypochrome erythrocytes indirectly evidencing for insufficient supply and iron utilization in bone marrow. Pathogenetic mechanisms of anemia development in CRF patients on PD may be both low EP and high levels of proinflammatory cytokines as well as oversecretion of ferritin by activated by monocytes/macrophages ferrin, promoting apoptosis of late erythropoiesis precursors, development of ineffective erythropoiesis and having a suppressive effect on erythropoiesis cell precursors.

Anemia↗
PubMedDate not supplied

[Effect of acute and chronic ethanol consumption on rat brain and liver monoamine oxidase activity].

Monoamine oxidase (MAO) activity was studied in hyporthalamus, midbrain, brain stem and liver tissue of rats after single and repeated administration of ethanol using noradrenaline and dopamine as MAO substrates. Small, but statistically significant decrease in the activity MAO of the "A" type was found in rat liver tissue after repeated administration of alcohol. Both single and repeated administrations of ethanol did not affect the enzymatic activity in the brain. Prolonged administration of the MAO inhibitor parnate simultaneously with alcoholization of rats led to inhibition of the MAO activity to the same degree as in control animals treated with the parnate only.

Alcoholic Intoxication↗