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Biomedical subjects

L A Runge

Publications and source records attributed to L A Runge.

10 recordsLinked to original sources
PubMed1986

High IgM antibody to human T-lymphotropic virus type I in systemic lupus erythematosus.

Twenty-six percent of 53 systemic lupus erythematosus sera had high levels of IgM antibody to human T-lymphotropic virus Type I, significantly more than the 5% of normal controls. Neither IgG antibodies to Type I virus nor IgM or IgG antibodies to Type II virus were increased in lupus. Further analysis using competition immunoassay and Western blot techniques also suggested that the IgM Type I antibodies in lupus sera were directed against viral antigens but did not completely exclude a nonviral reaction. Other studies also have not found IgG antibodies to the Type I virus but have not tested for IgM antibodies. Our study suggests that human T-lymphotropic virus Type I or a related virus may be involved in the pathogenesis of some cases of systemic lupus erythematosus.

Adolescent↗
PubMed1986

The inheritance of Felty's syndrome in a family with several affected members.

A family in which 3 siblings had Felty's syndrome is described. All affected family members shared the common haplotype HLA-A2, B15, Cw3 and DR4. In addition, all affected siblings possessed the A2 and ABO phenotype. Four unaffected siblings possessed either the HLA-A2, B15, Cw3 and DR4 haplotype or the A2 ABO phenotype or neither but not both. We believe our data support the hypothesis that multiple genetic factors are involved in the predisposition of family members to Felty's syndrome.

Adult↗
PubMed1985

Testing stable angina. Expert opinion versus decision analysis.

Controversy still surrounds the use of invasive and noninvasive tests after establishing the clinical diagnosis of stable angina pectoris. The authors employed threshold analysis, a multifactorial mathematical instrument, and the risk and benefit data available in 1983 to determine that the optimal diagnostic approach is to perform a stress test first and then consider angiographic evaluation and surgery for those patients with a positive result. This decision rule was compared with the diagnostic approaches proposed by 61 randomly selected board-certified cardiologists. Fifteen different two-test strategies were proposed by the 61 experts. Fifty-three chose a stress test as the initial procedure and 37 would proceed to coronary angiography if the stress test were positive. Thus a majority of the experts studied (60.6%) proposed an approach identical to the result of threshold analysis. Three respondents thought that no tests were necessary for the evaluation of stable angina pectoris. Twelve cardiologists would not recommend coronary angiography in stable angina patients with unequivocally positive stress tests. Their degree of familiarity and practical experience with the invasive procedure, as well as their perception of risks and benefits of coronary angiography and coronary artery bypass surgery, was not different than that of the cardiologists holding the majority view. For this group the decision analytic model could be used to correct judgmental biases and to optimize the diagnostic evaluation of coronary artery disease.

Angina Pectoris↗
PubMed1979

Treatment of rheumatoid arthritis with levamisole: long-term results and immune changes.

We treated 29 rheumatoid arthritis patients with levamisole. on the basis of a 25% improvement in any 3 of 6 measurements 95% of the patients had a favourable response within 20 weeks. However, 64% of the patients discontinued levamisole by 40 to 60 weeks because of rash or secondary treatment failures. Delayed skin reactivity to streptokinase-streptodornase increased significantly in the entire treatment group, but there was in inverse correlation between skin test enhancement and clinical response. There was no overall change in lymphocytes response to phytohaemagglutinin (PHA) after 4 and 16 weeks of treatment, but seven patients with enhanced lymphocyte responsiveness to PHA experienced an earlier clinical response to levamisole. Treatment with levamisole frequently results in clinical improvement in rheumatoid arthritis, but this is not clearly related to a stimulatory effect on cell-mediated immunity. Its long-term usefulness may be limited by a high incidence of relapse and rash.

Arthritis, Rheumatoid↗
PubMed1976

Search for antigen in rheumatoid synovial macrophages.

Peripheral blood monocytes and synovial macrophages obtained from 21 patients with rheumatoid arthritis and from 13 controls were cultured with autologous peripheral blood lymphocytes and stimulation measured by thymidine uptake. Rheumatoid macrophages and monocytes induced a small but significant degree of lymphocyte transformation, and those from the controls did not. The degree of stimulation appears to be more consistent with the nonspecific effect of lymphocyte activating factor, rather than with the presence of a specific synovial antigen.

Antigens↗
PubMedDate not supplied

Treatment of rheumatoid arthritis with levamisole. A controlled trial.

Levamisole, an anthelminthic agent with immunostimulatory properties, was used in a double-blind, controlled therapeutic trial in rheumatoid arthritis. Patients received either levamisole 100 mg 4 days a week, or placebo, for a period of 4 months. Significant improvement in the treated group, as compared with the control group, was found in the number of tender and swollen joints, grip strength, range of joint motion, sedimentation rate, and C-reactive protein. On double-blind global evaluation by the examining physicians, 9 of 14 patients on levamisole and none of 13 on placebo were considered to have improved. Adverse effects did not differ in frequency between the two groups except for mild alteration in taste, which was more common with levamisole.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Specificity of antibodies in rheumatoid arthritis. I. A controlled study of humoral antibodies to bovine nasal cartilage components.

Rheumatoid arthritis (RA) sera were compared in a matched, controlled study to non-RA sera for their ability to react in ELISA with antigen preparations extracted from bovine nasal cartilage. Antibodies to matrix proteins, proteoglycans and whole extract were significantly higher in RA sera than in non-RA with the reactivity for matrix proteins giving the largest difference. There was no significant difference between RA and non-RA antibody levels for collagen and collagen alpha chains. By SDS-PAGE, large pore composite gel electrophoresis, and uronic acid analysis, the matrix protein fraction contained 8 major proteins as well as two electrophoretic species of low density proteoglycans distinct from the major high density cartilage proteoglycans. Further fractionation provided a proteoglycan-free preparation containing six major proteins of 66-13 kd with which the RA sera were still highly reactive.

Adult↗