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PubMed · 4087952

Testing stable angina. Expert opinion versus decision analysis.

Abstract

Controversy still surrounds the use of invasive and noninvasive tests after establishing the clinical diagnosis of stable angina pectoris. The authors employed threshold analysis, a multifactorial mathematical instrument, and the risk and benefit data available in 1983 to determine that the optimal diagnostic approach is to perform a stress test first and then consider angiographic evaluation and surgery for those patients with a positive result. This decision rule was compared with the diagnostic approaches proposed by 61 randomly selected board-certified cardiologists. Fifteen different two-test strategies were proposed by the 61 experts. Fifty-three chose a stress test as the initial procedure and 37 would proceed to coronary angiography if the stress test were positive. Thus a majority of the experts studied (60.6%) proposed an approach identical to the result of threshold analysis. Three respondents thought that no tests were necessary for the evaluation of stable angina pectoris. Twelve cardiologists would not recommend coronary angiography in stable angina patients with unequivocally positive stress tests. Their degree of familiarity and practical experience with the invasive procedure, as well as their perception of risks and benefits of coronary angiography and coronary artery bypass surgery, was not different than that of the cardiologists holding the majority view. For this group the decision analytic model could be used to correct judgmental biases and to optimize the diagnostic evaluation of coronary artery disease.

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BibTeXRIS

P Manu, L A Runge. 1985. Testing stable angina. Expert opinion versus decision analysis.. https://pubmed.ncbi.nlm.nih.gov/4087952/

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Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

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