PubMed Health⌕ Search

Biomedical subjects

L A Yannuzzi

Publications and source records attributed to L A Yannuzzi.

At least 109 records · Page 6Linked to original sources
PubMed1985

Krypton red laser photocoagulation for subretinal neovascularization.

One hundred fifty-seven patients with subretinal neovascularization (SRN) were treated in a prospective, nonrandomized, consecutive study with the krypton red laser (KRL). The patients were analyzed with respect to age, etiology of the SRN, location of the SRN, and pre- and post-treatment visual acuity in patients with at least three months follow-up. Previous studies have not investigated KRL photocoagulation within the foveal avascular zone (FAZ). The results of this study compare favorably with other large series in which patients with SRN located outside the FAZ were treated with the argon blue-green laser (ABGL).

Adult↗
PubMed1985

Recurrent subretinal neovascularization.

A retrospective analysis of a consecutive series of patients treated with krypton red laser (KRL) photocoagulation for subretinal neovascularization (SRN) secondary to drusen-related macular degeneration (DMD) was carried out to investigate the frequency and nature of recurrent neovascularization (recurrence). A classification of various types of recurrences based on the clinical and fluorescein angiographic features and the onset of their appearance in the postoperative course was used in this study. Patient, fundus, and membrane variables were examined in search of relevant high risk factors predisposing to recurrences. The membrane's proximity to the fovea and its relative lack of pigmentation were individual factors which were associated with a high risk of recurrence (P less than 0.05 for distance and P = 0.005 for color). Multivariate analysis also indicated that a greater distance from the fovea (P less than 0.05) and a darker color (P = 0.002) were favorable features to the primary membrane, reducing the probability of a recurrence. Overall, 39% of the patients experienced recurrences (23% of the patients had treatable recurrences and 16% had non-treatable recurrences extending under the center of the fovea). The membranes recurred predominantly at the margin of the photocoagulation burn. The recurrences were also noted relatively early in the postoperative course, 65% within two months after photocoagulation of the primary membrane. The fluorescein angiographic and clinical nature of these membranes and the visual effect of retreatment are also discussed in the paper.

Aged↗
PubMed1984

A perspective on the treatment of aphakic cystoid macular edema.

Concepts related to the pathogenesis of aphakic cystoid macular edema (ACME) are presented with reference to possible management considerations. The role of certain aspects of cataract surgical technique, laser photocoagulation, vitreoretinal surgery and medical therapy utilizing corticosteroids and antiprostaglandins are discussed. The difficulties encountered in the evaluation of the efficacy of any treatment modality advocated for ACME are reviewed. Preliminary results of studies on the medical treatment of ACME currently under investigation by the author are also presented.

Anti-Inflammatory Agents↗
PubMed1984

Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy.

Twenty-five patients with central serous pigment epitheliopathy (CSP), also known as central serous chorioretinopathy, have been observed to have inferior hemispheric retinal pigment epithelial atrophic tracts, presumptive of antecedent retinal detachments. Five of these patients were noted to have clinically discernible, dependent peripheral retinal detachments. The clinical and fluorescein angiographic features of these patients are reviewed. Alterations in the retina, the retinal pigment epithelium (RPE) and the choroid are also described. They include the commonly associated manifestations of CSP such as RPE leaks and macular detachment as well as some newly recognized disturbances such as retinal capillary dilatation (telangiectasia), retinal capillary leakage, retinal lipid deposition, cystoid macular edema, choriocapillaris atrophy, choroidal neovascularization and disciform scarring.

Adult↗
PubMed1982

Krypton red laser photocoagulation for subretinal neovascularization.

A series of 75 well-defined, consecutive patients with subretinal neovascularization secondary to a variety of macular diseases were treated with krypton red laser (KRL) photocoagulation and are reported on prospectively. Two thirds of the patients had subretinal neovascularization secondary to involutional (senile) macular degeneration. Most patients had clinical and/or fluorescein angiographic manifestations of neovascularization that posed a poor visual prognosis. The technique of treatment using the krypton red wavelength, as well as special considerations in the pre- and post-operative management, are reviewed. The results suggest that this wavelength is effective in the successful, anatomic elimination of subretinal neovascularization and improvement of the visual status with certain potential advantages compared to conventional argon blue-green laser (ABGL) radiation. Since this clinical study is void of randomization and controls, no absolute conclusions can be made with regard to the effectiveness of this form of treatment compared to other laser treatments or to the natural course of the macular diseases themselves. However, the results of this study are extremely encouraging, warranting further investigation.

Fluorescein Angiography↗
PubMed1982

A modified Amsler grid. A self-assessment test for patients with macular disease.

A Modified Amsler Grid, the size of a conventional credit card, has been developed as a suitable alternate to the full-scale version. The size of the grid makes it extremely convenient for patients in our highly mobile society. When viewed twice (vertically and horizontally), it corresponds well to the topography of the central macula. In this capacity the Modified Amsler Grid is a useful adjunct to the overall management of patients with macular diseases which may potentially be associated with exudative manifestations.

Humans↗
PubMed1982

Krypton red laser photocoagulation of the ocular fundus.

The theoretical rationale, the histopathologic evidence, and the preliminary clinical studies related to krypton red laser (KRL) photocoagulation of the ocular fundus are reviewed. The authors report on their experience with currently available laser systems using this wavelength (647.1 nm) for photocoagulation of retinal vascular proliferative diseases and chorioretinal diseases associated with exudative manifestations. A histopathologic and clinical comparison of argon blue-green laser (ABGL), the pure argon green laser (AGL), and the krypton yellow laser (KYL), with reference to photocoagulation treatment of the ocular fundus is also discussed.

Diabetic Retinopathy↗
PubMed1981

Incidence of aphakic cystoid macular edema with the use of topical indomethacin.

A prospective, controlled study utilizing topical 1% aqueous indomethacin was employed in an attempt to determine the incidence of aphakic cystoid macular edema (ACME) following cataract surgery. The incidence of ACME in the indomethacin-treated group was significantly less than in the control group five weeks after cataract surgery (36% vs 18%; P less than 0.02). There was no significant difference in the two groups ten weeks after surgery when studied by fluorescein angiography (34.6% vs 21%; P less than 0.10). The biochemical and pharmacological rationale for the use of the antiprostaglandin indomethacin in the management of ACME was reviewed. This revealed sufficient experimental and clinical evidence for continued research in the area of prostaglandin inhibitors for the possible prevention or treatment of this disorder.

Cataract Extraction↗
PubMed1981

Microsurgical management of macular epiretinal membranes (macular pucker).

Surgical management of selected macular epiretinal membranes is possible through the use of microsurgical pars plana vitreoretinal membranectomy. Visual improvement can be significant with resolution of traction retinal detachment and retinal distortion. Complications are similar to other forms of vitreous surgery. In a series of 9 selected cases with severe reduction of visual acuity secondary to macular pucker, microsurgical membranectomy was performed with encouraging results.

Adult↗
PubMed1979

The effect of indomethacin pretreatment on aphakic cystoid macular edema.

In patients treated with oral indomethacin for four weeks after intracapsular cataract extraction, five of 57 eyes (9%) had cystoid macular edema four to six weeks postoperatively as shown by fluorescein angiography. In a control group not treated with indomethacin, 15 of 34 eyes (44%) had cystoid mascular edema. Oral indomethacin, therefore, caused a statistically significant decrease in the incidence of aphakic cystoid macular edema.

Adult↗