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Biomedical subjects

L Barnes

Publications and source records attributed to L Barnes.

At least 109 records · Page 6Linked to original sources
PubMed1989

Issues in psychiatric caregiving.

This report presents descriptive data from a pilot investigation of 20 family caregivers to the psychiatrically disabled. Data were obtained through focused interviews with caregivers recruited from community organizations and clinical services. The model subject was a middle-aged mother caring for an adult child with schizophrenia. Qualitative analysis of interview data identified major concerns and support needs of individuals who assume this stressful role. Mental health nurses may assist caregivers to obtain support, reduce risks to their own well-being, and to promote well-being of the mentally ill.

Adult↗
PubMed1988

Malignant fibrous histiocytoma of the head and neck. A report of 12 cases.

The clinical and pathologic features of 12 cases of malignant fibrous histiocytoma of the head and neck were studied. These tumors occurred in seven men and five women ranging in age from 21 to 75 years (average, 55 years). The sinonasal tract was the most common site (four cases), followed by the parotid area (two cases), oral cavity (two cases), soft tissues of the neck (two cases), mandible (one case), and larynx (one case). Pathologically, 11 of the tumors were subclassified as storiform-pleomorphic and one as inflammatory. All were treated initially with surgery with or without postoperative irradiation. Five (42%) of the patients experienced local recurrences, three (25%) developed distant metastases (especially to the lungs), and five (42%) died of their disease, all of the latter occurring within two years of diagnosis. No patient developed bona fide cervical lymph node metastasis, although one did have a positive paraparotid node as a result of direct extension from an adjacent tumor.

Adult↗
PubMed1988

Vitiligo and the Vogt-Koyanagi-Harada syndrome.

Vitiligo is a common acquired systemic disease that can be associated with several different autoimmune disorders. Besides the psychologically upsetting depigmentation of the skin that it causes, it can be associated with ocular abnormalities. There are three different theories regarding the etiology of vitiligo, none of which is entirely satisfactory. There are some valuable animal models for studying the disease, but they obviously have limitations in their application to the human disease. The melanocyte is present in other areas besides the skin, including the leptomeninges, the retinal pigment epithelium, the uveal tract, and the inner ear. Therefore, it is not surprising that whatever process destroys the melanocyte in the skin can also affect diverse tissues such as the eye, the ear, and the central nervous system. It is postulated that the Vogt-Koyanagi-Harada syndrome may be part of the systemic disease, vitiligo.

Animals↗
PubMed1987

Suppression of the cutaneous immune response following topical application of the prostaglandin PGE2.

UVB irradiation (290-320 nm) and topical applications of arachidonic acid (AA) in mice decrease the number of identifiable Langerhans cells and alter the cutaneous immune response. Application of contact allergens such as dinitrofluorobenzene (DNFB) to irradiated or AA-treated skin induces antigen-specific tolerance. Indomethacin (IM), a cyclooxygenase inhibitor, administered orally to mice prior to UVB irradiation or prior to the topical application of arachidonic acid, abrogates suppression of contact hypersensitivity (CHS) to DNFB. This suggests a byproduct of arachidonic acid generated through the cyclooxygenase pathway may be involved in the immune suppression. Topical application of various prostaglandins (PGE2, PGD2, PGF2 alpha, and CTXA2) did not cause alterations in the population density of the identifiable Ia+ dendritic Langerhans cells. PGE2, but no other tested agent, produced a suppression of the CHS response to DNFB. These observations suggests that of the various prostaglandins, PGE2 might be one of several biochemical signals which mediate the suppression of contact hypersensitivity reactions following ultraviolet radiation exposure. However, the mechanisms by which PGE2 produces its suppressive effects have not been identified.

Administration, Topical↗
PubMed1987

Crusted (Norwegian) scabies. Occurrence in a child undergoing a bone marrow transplant.

A case of crusted (Norwegian) scabies is reported in a child who was a recipient of a bone marrow transplant. The infestation is presumed to have predated the bone marrow transplant and continued asymptomatically during chemotherapy and total body x-irradiation in preparation for transplant. The child was asymptomatic until 23 days after transplantation, when bone marrow engraftment was attained. The altered host-parasite relationship is emphasized by the observation that the onset of symptomatic pruritus coincided with successful engraftment.

Bone Marrow Transplantation↗
PubMed1987

A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group.

Methotrexate (MTX) has demonstrated significant activity against relapsed and metastatic osteosarcoma. However, there is little published data to indicate the appropriate dose for MTX when given as a component of a multidrug regimen for the treatment of osteosarcoma. Therefore, the investigators at the Childrens Cancer Study Group undertook a randomized clinical trial that compared Adriamycin and vincristine given with either high-dose methotrexate or moderate-dose methotrexate as postoperation chemotherapy in the treatment of childhood osteosarcoma. We report here the results for 166 patients with completely resected nonmetastatic disease of an extremity. The two therapies demonstrated equivalent disease-free survival (DFS). Further, no therapy prejudices survival after relapse. Approximately 38% of patients remain disease free 4 years after diagnosis. Two relapses occurred in patients free of disease at least 36 months after initiation of treatment. Some factors found by other investigators to be prognostic of poorer DFS, namely, male sex, primary tumor in the humerus or femur, and larger primary tumors, demonstrated similar though not statistically significant trends. The presence of spontaneous necrosis in the tumor sample from the definitive surgery was associated with poor prognosis for DFS. We postulate that this feature represents rapidly growing tumors with increased potential for metastases.

Adolescent↗
PubMed1987

OKT3 monoclonal antibody reversal of renal and hepatic rejection in pediatric patients.

The monoclonal antibody OKT3 was previously shown to be superior to conventional high-dose steroid therapy for reversal of acute rejection of renal allografts. Furthermore, OKT3 was effective in reversing acute renal or hepatic allograft rejection that was resistant to treatment with steroids, anti-thymocyte globulin, or both. Our analysis demonstrates that OKT3 is also effective in pediatric patients in reversing acute rejection of renal allografts (rescue treatment) or hepatic allografts (primary or rescue treatment).

Adolescent↗
PubMed1987

"Ossifying" hemangiomas of the temporal bone: evaluation with CT.

Hemangiomas of the temporal bone that affect the facial nerve are more frequent than previously suspected. Six patients with slowly progressive or recurrent facial paralysis were evaluated with computed tomography. In each case, a lesion was demonstrated that enlarged the facial nerve canal and contained intratumoral spicules of bone. Typically the temporal bone was expanded by a lesion with an indistinct margin. Demonstration of the typical radiologic findings, especially the intratumoral bone spicules, makes hemangioma a much more likely diagnosis than schwannoma.

Adult↗
PubMed1987

Oncocytic Schneiderian papilloma in a young adult: a rare diagnosis.

The oncocytic Schneiderian papilloma (OSP) is a rare neoplasm of the nose and paranasal sinuses. The majority of the approximately twenty patients reported in the literature with this papilloma have been over the age of fifty at the time of diagnosis. The 33-year-old woman reported here is the youngest patient with this lesion to date. The OSP should be considered in the work-up of all unilateral nasal polypoid lesions. This lesion's propensity for recurrence and its documented association with synchronous malignant disease warrant surgical excision by en bloc resection of the lateral nasal wall, with corresponding careful microscopic evaluation of all excised tissue.

Adult↗
PubMed1986

Pustular pyoderma gangrenosum associated with ulcerative colitis in childhood. Report of two cases and review of the literature.

Pyoderma gangrenosum is a cutaneous disorder associated with systemic diseases such as ulcerative colitis, Crohn's disease, rheumatoid arthritis, and blood dyscrasias. We are reporting two cases of pustular pyoderma gangrenosum associated with ulcerative colitis. One patient had inactive bowel disease when she developed her third episode of pustules, erosions, and nodules on the left leg. The other patient exhibited a widespread painful vesiculopustular eruption that coincided with the onset of her colitis. Both patients presented with pustules as the primary manifestation of their pyoderma gangrenosum. Histologic examination of skin from both patients revealed an acute perifollicular inflammation. Pyoderma gangrenosum should be considered in the differential diagnosis of pustular disorders in children with underlying conditions such as ulcerative colitis.

Abscess↗
PubMed1986

Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.

Intestinal-type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinuses may occur sporadically or as an occupational-related hazard, especially in cases of wood dust exposure. The clinical and pathologic features of 17 cases of sporadic-type ITAC are presented and compared to those among woodworkers. Both groups are analyzed collectively to define further the biological spectrum of this rare neoplasm. Histologically, five variants of ITAC were recognized: papillary, colonic, solid, mucinous, and mixed. The nine men and eight women in this series ranged from 31 to 80 years of age. Eight tumors originated in the maxillary sinus, seven in the nasal cavity, and two in the ethmoid sinus. Unilateral nasal obstruction and epistaxis, averaging 6.8 months in duration, were the most common symptoms. At least four of the patients are known to have died of their disease. In contrast, ITAC in woodworkers occurs primarily in men, originates almost exclusively in the nasal cavity or ethmoid sinus, and has a better prognosis. Data pooled from 213 cases of ITAC indicate that 53% of patients have experienced local recurrences following therapy, 8% (range 0-22%) have developed cervical lymph node and 13% (range 0-29%) distant metastases, and 60% have died of their disease. Of those dying, 80% did so within 3 years of diagnosis (range 1 month to 9.1 years).

Adenocarcinoma↗
PubMed1986

Laser treatment of hereditary multiple glomus tumors.

Familial multiple glomus tumors are rare. A family is reported here with the disease documented in three generations. While this type of glomus tumor is not classically associated with pain, all members of this family who exhibited multiple glomangioma were symptomatic. Treatment with both the argon laser and carbon dioxide laser was successful in relieving symptoms and improving the appearance of only the more superficial glomus tumors.

Adolescent↗