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Biomedical subjects

L Bodner

Publications and source records attributed to L Bodner.

At least 55 records · Page 3Linked to original sources
PubMed1984

Saliva secretion from the rat submandibular gland after retrograde infusion of radiographic contrast media.

Rat submandibular saliva was collected at various times after retrograde infusion of water-soluble (Renografin 60%) or lipid-soluble (Lipiodol UF) radiographic contrast medium. Significant alterations in flow rate occurred following heavy parenchymal filling with both types of contrast media. Occasional changes in protein concentration, lactoperoxidase activity, and K+ levels were also noted. These changes were relatively mild and transient, and gland function had generally returned to normal by one wk after infusion. No alterations in glandular function were detected after infusion of contrast medium to a degree (ductal filling) comparable to that usually employed in clinical sialography.

Animals↗
PubMed1984

Rat parotid cell function in vitro following X irradiation in vivo.

The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K+ efflux and reuptake), amino acid transport (alpha-amino[14C]isobutyric acid), and an intermediary metabolic response ( [14C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.

Aminoisobutyric Acids↗
PubMed1983

Multiple transduction mechanisms are likely involved in calcium-mediated exocrine secretory events in rat parotid cells.

The parotid gland of the aged rat provides an example of an altered alpha 1-adrenergic physiologic response (K+ efflux) resulting from a postreceptor perturbation in signal transduction mechanisms (Ito, H., Baum, B. J., Uchida, T., Hoopes, M. T., Bodner, L. & Roth, G. S. (1982) J. Biol. Chem. 257, 9532-9538). This alteration in gland function can be completely circumvented by eliciting K+ efflux via the Ca2+-ionophore, A23187, at several Ca2+ concentrations (ibid.). Since Ca2+ is purported to mediate other secretory events in the rat parotid, we have probed neurotransmitter regulated Ca2+ mobilization and secretory mechanisms in this tissue by employing an aging paradigm. The responses studied were alpha-adrenergic- and muscarinic-cholinergic-mediated K+ efflux, 45Ca2+ release, and amylase secretion. No differences were detected between young (3 months) and old (24 months) cell preparations for any muscarinic-cholinergic agonist-induced response studied. Following alpha-adrenergic stimulation, K+ efflux and 45Ca2+ release from old cell preparations were reduced markedly, while no changes were found for the amylase secretion response. These results suggest that 1) alpha-adrenergic and cholinergic signal transduction mechanisms for K+ efflux and 45Ca2+ release are dissociated in cells of the rat parotid gland, and 2) following alpha 1-adrenergic stimulation, signal transduction likely proceeds by at least two pathways, one which is apparently involved in protein excytosis (intact in cells from old rats) and the other which is apparently involved in K+ efflux and 45Ca2+ release (perturbed in old cells).

Aging↗
PubMed1983

Aging and oral motor function: evidence for altered performance among older persons.

A physical examination procedure was used to evaluate oral motor functions in a population of 257 community-dwelling males and females ranging in age from 23-88 yr. An increased prevalence of altered motor performance with age was found for parameters measuring lip posture and masticatory muscle function. Also, males, but not females, showed a higher prevalence of alterations in tongue function and in swallowing.

Adult↗
PubMed1982

Modulation of rat parotid cell alpha-adrenergic responsiveness at a step subsequent to receptor activation.

Parotid gland acinar cells, prepared from 12- and 24-month-old rats, show decreased physiological responsiveness to alpha-adrenergic stimulation in vitro compared to cells from 3-month-old rats. K+ efflux, an index of water and electrolyte secretion, was approximately 35% lower with 12- and 24-month-old parotid cells. No loss of alpha-adrenergic receptors, their binding affinity for specific alpha-adrenergic ligands, or their relative subtype distribution, accompanied the diminished exocrine function. Conversely, a significant reduction in alpha-adrenergic-mediated phospholipid turnover in, and 45Ca2+ efflux from, parotid cells of older rats was observed. These changes in phospholipid metabolism and Ca2+ flux were parallel to changes seen in K+ efflux as judged by dose-response studies. When the alpha-adrenergic receptor was by-passed by using the Ca2+-ionophore A-23187 to elicit K+ efflux, young and old parotid cells were equally responsive. In aggregate the findings suggest that parotid gland cells from older rats display an altered alpha-adrenergic signal transduction mechanism at a site between the receptor and phospholipid turnover/Ca2+ mobilization.

Aging↗
PubMed1982

Effect of X-ray irradiation on primary mineralization in rat alveolar bone.

The effect of X-ray irradiation on the process of primary mineralization in bone was studied by biochemical and ultrastructural methods. A single dose of 1500R was administered to the head region of rats. The animals were examined immediately after irradiation and 1, 2 and 3 weeks later. Fractions of isolated cells and extracellular matrix vesicles were prepared from the maxillary alveolar bone of irradiated and untreated rats by collagenase digestion and differential centrifugation. The protein content and activities of vesicular phosphatases were determined in both fractions. A continuous decrease in the activity of alkaline phosphatase could be observed in both cell and matrix vesicle fractions during a three-week follow up after irradiation. Acid phosphatase activity decreased only in the vesicle fraction. Transmission electron microscopy of irradiated bone tissue revealed that many matrix vesicles were devoid of intact membranes and apatite crystals. Calcifying nodules were abundant in the matrix without their apparent fusion into larger mineralized structures. It is suggested that irradiation interferes with enzymatic processes associated with primary mineralization.

Alveolar Process↗
PubMed1982

A modern approach to prevention and treatment of oral bleeding in patients with hepatocellular disease.

Dental treatment for patients with hepatocellular disease constitutes a very complex problem because of their severe bleeding tendency. It seems that bleeding from the oral structures follows organ-specific patterns. The use of systemically administered antifibrinolytic agents, together with the local use of Gelfoam, cyanoacrylate spray, and intraligamentary anesthesia make possible bleeding-inducing procedures without exaggerated hemorrhage. This approach avoids the need for transfusion and hospitalization for dental treatment, making such treatment cheaper and more accessible.

Adult↗
PubMed1982

Unusual cyst of the zygoma.

An unusual cyst of the zygoma is described. Three patterns of development of the cyst are suggested, namely: 1. Residual cyst of retained deciduous roots with metaplasia of the odontogenic epithelium into respiratory epithelium. 2. Fissural cyst of the zygomatico-maxillary suture. 3. Connection to the maxillary sinus, by a developmental exvagination or trauma to the sinus that caused entrapment of epithelium at the fracture line, with subsequent proliferation.

Aged↗
PubMed1981

Computer analyzed EEG in amphetamine-responsive hyperactive children.

Electroencephalographic (EEG) frequency analysis and evoked potentials (EPs) of 27 hyperactive children were examined to determine which, if any, of these electrophysiological parameters might be useful for the selection of those children likely to respond to stimulant medication. The children were treated with placebo, d-amphetamine, and l-amphetamine in double-blind fashion and in random order. EEGs for frequency analysis, visual EPs, and auditory EPs were obtained before and during treatment. Off medication, hyperactive responders to amphetamine had higher predominant beta frequency and shorter latencies of some EP waves than did nonresponders. Although the findings reported here would not select all responders, they would allow the exclusion of most nonresponders.

Adolescent↗
PubMedDate not supplied

Use of xenograft bone with aspirated bone marrow for treatment of cystic defect of the jaws.

Xenografts of Kiel bone in combination with autologous aspirated bone marrow were used to graft 20 cystic defects in the jaws. Sixteen cases (80%) were successful. Results were evaluated by clinical and radiographic follow-up of the patient up to 4 years (average 2.3 years) after surgery. Inability to create a water-tight closure followed by immediate secondary infection were considered as the causes for failure rather than rejection by the host.

Adolescent↗
PubMedDate not supplied

Nodular fasciitis of the oral mucosa: light and electron microscopy study.

Nodular fasciitis of the oral mucosa is a rare lesion. The present article describes an additional case and discusses the difficulties in the histologic diagnosis. The final diagnosis is based on immunohistochemistry and electron microscopic morphology. Nodular fasciitis should be considered in the differential diagnosis of swellings in the oral mucosa.

Adult↗
PubMedDate not supplied

CT of cystic jaw lesions.

OBJECTIVE: Our goal was to compare the efficacy of CT with that of plain film radiography (PFR) in analyzing the three-dimensional shape and structure of cystic jaw lesions. MATERIALS AND METHODS: Twenty patients with cystic lesion of the jaw were studied by PFR and CT. The three-dimensional outline of the cyst and the distances between the cyst wall and adjacent vital teeth, cortical jaw bone, maxillary sinus, and mandibular canal were estimated on PFR and on CT scans. RESULTS: Computed tomography was superior to PFR in the demonstration of the three-dimensional bony margins of the cyst and in determination of its proximity to adjacent vital structures (p < 0.01, sign test). CONCLUSION: Application of CT is useful for diagnosis and treatment planning of cystic lesions of the jaws.

Adult↗
PubMedDate not supplied

Impacted primary incisor: report of case.

Impaction of a primary incisor is very rare, with only one previous report in the dental literature. After surgical exposure, the case reported here had a normal course of eruption during follow-up.

Child, Preschool↗