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L Cionini

Publications and source records attributed to L Cionini.

63 records · Page 4Linked to original sources
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Clinical data and therapeutic approach in elderly patients with Hodgkin's disease.

The present study was undertaken to investigate the clinico pathologic features of Hodgkin's disease in a series of 114 elderly patients (age greater than 60 yrs), with particular reference to prognosis and treatment. Mixed cellularity (63.2%) was the most frequent histologic subtype. Clinical presentation was characterized by superficial lymphadenopathy (92%) and the presence of general symptoms (40.4%); mediastinal involvement was observed in 16.6% of cases; 17.5% of patients had a primitive infradiaphragmatic presentation. Thirty-eight patients were treated with radiotherapy alone (33.4%), 69 with chemotherapy alone (60.5%), while 7 received combined treatment. Complete remission was obtained in 85 patients (74.6%), 25 of whom relapsed. Elderly patients had an overall 5-year survival rate of 61.8% (considering only disease progression as a cause of death). Proportional-hazard multi variate statistics showed that survival was strongly influenced by the achievement of complete remission (P less than 0.001) and stage (P = 0.011). The achievement of complete remission was also significantly linked to the presence of constitutional symptoms, advanced stage and age greater than 70 yrs, as demonstrated by discriminant statistical analysis. The actuarial incidence of second cancer (28.7% at 15 yrs) was slightly higher than that previously reported in younger patients. Overall, our data indicate that the treatment of elderly patients with Hodgkin's disease should be aimed at achieving a cure, using the same therapeutic modalities commonly employed in younger subjects.

Aged↗
PubMedDate not supplied

[Late myelopathy caused by ionizing radiation. Considerations on 3 cases].

Three cases of tardive myelopathy were identified among more than one thousand patients treated for tumors by X-rays at the Institute of Radiology of the University of Florence during the period 1974-83. In two of these, the clinical picture was that of a partial Brown-Séquard syndrome while in the third case it corresponded to a transverse myelitis. The myelopathy of the former patients can be attributed to the total radiation dose, which was very close to the tolerance limit. The third patient's disturbance, instead, involved additional factors of individual hypersensitivity of connective vascular tissue in response to the X-ray treatment. These cases, while few in number and lacking pathological investigation, call attention to this iatrogenic disorder which, though rare now thanks to progress in limiting radiation exposure, has not yet disappeared.

Adult↗
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Quality control follow-up.

In oncology and particularly in radiation therapy, the follow-up indicates the continuing and systematic clinical control of the patient after treatment. This control is aimed at the assessment of the evolution in time of three major aspects: the disease response to treatment (local control, survival), the onset of treatment-induced side-effects; the quality of life as the result of both. The quality of follow-up procedure aimed at the clinical investigations is one of the fundamental elements based on which the efficacy of the used diagnostic and therapeutic procedure is proven.

Continuity of Patient Care↗