[Electrocardiographic changes in pancreatitis].
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Biomedical subjects
Publications and source records attributed to L Conte.
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Notes on the anatomical and physiological features of the circulation are followed by a description of the main physiopathological aspects of the terminal circulation of the lower extremities. Reference is made to the pathogenesis and clinical and instrumental diagnosis of plantar ulcers in alcoholic polyneuritis, along with the symtoms constantly observed in a series of some 30 cases.
A case of fatal, diffused plasmacytoma is presented. The picture also included leukaemia and is felt to be an example of plasma-cell leukaemia, as opposed to plasmacytoma in the light of the anatomical and clinical features of the onset and course: high and very pronounced plasma-cell leukocytosis, diffuse proliferation of the plasma cell series in the bone marrow, spleen and lymph nodes, infiltration of plasma cells in the parenchymal organs, extremely rapid progress with serious anaemia, haemorrhage, general organic involvement, high fever, and infection.
The calculation of the dose distribution in the thyroid tissues and of the maximum permissible concentrations in the air and in drinking water was carried out for 123I. In fact because of the recent use of this radionuclide in radioisotopic diagnostics the dose to both the patients' and operators' thyroids due to 123I must to be known. In order to obtain a correct estimate it is necessary, however, to consider the distribution of the radionuclide in the thyroid tissue and the changes in this distribution depending on the dimensions of the follicles. Taking into account the dose at the follicular cell-colloid interface, the maximum permissible concentrations in the air and in drinking water were calculated as being 6 x 10-8 muCi/cm3 and 4 x 10-4 muCi/cm3 respectively.
An attempt to evaluate the total radiation risk caused by the diagnostic use of radionuclides was made. The estimate was based on the calculation of the genetically significant dose the mean dose in the bone marrow and the dose in the whole body and in the organs which accumulate the radionuclides. The statistical data were furnished by the nuclear medicine service of the Province of Varese.
In order to estimate the renal plasma flow and glomerular filtration rate during the course of renography, a method was developed using simultaneously 131I Hippuran and 169Yb DTPA. First results obtained in a survey of approximately 200 patients are encouraging. The method permits an accurate evaluation of the renal function. In addition, by comparing the clearance rate of the two radiocompounds one can also obtain some interesting diagnostic information which can contribute usefully to the interpretation of renographic tracings and/or gamma camera sequential images.
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