Biomedical subjects

L Dall' Asta

Publications and source records attributed to L Dall' Asta.

2 recordsLinked to original sources

PubMed1989

Synthesis and biological properties of 1-methyl-2-[(4-aminophenyl)-sulfonyl-]amino-5-nitro imidazole.

The synthesis of 1-methyl-2-[(4-aminophenyl)sulfonyl] amino-5-nitroimidazole 5 is described. The new sulfonamide 5 shows a good activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria. Compound 5 is well absorbed in rats after oral administration but the plasma levels are inferior to those of sulfadiazine and sulfamethoxazole.

Animals↗

PubMed1989

New isosorbide 5-mononitrate derivative with hypotensive activity.

Synthesis and pharmacological properties of the 5-fluoro-nicotinic ester with isosorbide-5-mononitrate 3 are reported. The new compound shows an in vitro activity on rabbit aortic helical strips five times higher than isosorbide-5-mononitrate. The hypotensive activity in guinea-pigs of 3 is markedly superior to that of 5-ISMN. In the rat 3 shows a bioavailability and an acute toxicity inferior to those of 5-ISMN after oral administration.

Animals↗