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PubMed · 2775521

New isosorbide 5-mononitrate derivative with hypotensive activity.

G Coppi·F Borella·M T Gatti·A Comini·L Dall' Asta
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Abstract

Synthesis and pharmacological properties of the 5-fluoro-nicotinic ester with isosorbide-5-mononitrate 3 are reported. The new compound shows an in vitro activity on rabbit aortic helical strips five times higher than isosorbide-5-mononitrate. The hypotensive activity in guinea-pigs of 3 is markedly superior to that of 5-ISMN. In the rat 3 shows a bioavailability and an acute toxicity inferior to those of 5-ISMN after oral administration.

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AnimalsAntihypertensive AgentsBlood PressureChemical PhenomenaChemistryFemaleGuinea PigsIn Vitro TechniquesIsosorbide DinitrateMaleMiceRabbitsRatsRats, Inbred StrainsJournal Article

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G Coppi, F Borella, M T Gatti, A Comini, L Dall' Asta. 1989. New isosorbide 5-mononitrate derivative with hypotensive activity.. https://pubmed.ncbi.nlm.nih.gov/2775521/

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