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Biomedical subjects

L Donner

Publications and source records attributed to L Donner.

At least 55 records · Page 3Linked to original sources
PubMed1978

Intestinal obstruction from appendiceal abscess in a newborn infant.

Perforated appendix in the newborn period is rare, its symptoms are occult and its outcome is disastrous. Associated mechanical small bowel obstruction as part of the clinical picture is rare indeed. We have treated a premature infant who presented with prolonged intermittent vomiting. Factors contributing to difficulty in diagnosis and to eventual succussful management are discussed.

Abscess↗
PubMed1978

Influence of heparin and defibrase on transplantability of syngeneic tumors in mice.

It had been previously demonstrated that fibrin clot might have an important role in the growth of malignant tumors and in metastasis formation. For this reason an attempt had been made to find out whether inhibition of fibrin formation by heparin or fibrinolysis induced by defibrase could limit tumor growth. Male mice of inbred strain were challenged with suspension of tumor cells. For anticoagulation and/or fibrinolytic therapy two different schedules were used. The treatment was started either simultaneously with the tumor transplantation, or one week prior to the injection of tumor cells. The size of tumors was bigger in the group of treated animals, when compared with the controls. However, the difference was not statistically significant. On the other hand, frequency of implanted tumors was significantly higher in animals with heparin and defibrase treatment or pretreatment.

Animals↗
PubMed1978

On the nature of fibrinolytic activity of arteries.

The plasminogen activator of the arterial wall was studied with the histochemical method of TODD. The plasminogen activator was removed from the sections after extraction with M-potassium thiocyanate. By this procedure we suggest that the activator demonstrated by the histochemical method is the same substance as that prepared by the extraction method with thiocyanate of ASTRUP and STAGE. However, a new fibrinolytic activity was restored after treatment of these extracted sections with streptokinase or urokinase. There were no differences in the different types of arteries examined and normal or atherosclerotic arteries. Similar findings were found when kidney or myocardial tissues were examined. It is suggested that the arterial and other tissues contain proactivator-plasminogen which is not extracted from the tissue by potassium thiocyanate and can adsorb streptokinase or urokinase.

Adult↗
PubMed1977

The plasminogen activator of the arterial wall.

The plasminogen activator in 645 specimens of various human arteries--thoracic, abdominal aorta, carotic, pulmonary, renal, basilar, coronary - was studied using Todd's histochemical method. 92 cadavers were used, 1--18 hours post mortem from subjects aged from 272 days to 83 years. 45 specimens of pulmonary, renal and splenic arteries were obtained during surgery. The greatest fibrinolytic activity was within the adventitia. Intima occasionally showed very little fibrinolytic activity, or none at all. No statistically significant differences in plasminogen activator activity were found between the various arteries examined. A statistically significant increase in fibrinolysis in adventitia of atherosclerotic arteries was established. No correlation was found between the fibrinolytic activity of the arteries and their alkaline phosphatase content. Some properties of the plasminogen activator of the arterial vessel wall were evaluated. Influence of storage, inactivation with epsilonaminocaproic acid and extracted with potassium thiocyanate was studied.

Adolescent↗
PubMed1977

Serum thrombopoietic activity following administration of vinblastine.

A possible role of humoral factors in the pathogenesis of vinblastine-induced thrombocytosis was examined. The thrombopoietic activity in serum of experimental animals was tested for its ability to stimulate the incorporation of 75-Se-selonemethionine into platelets of thrombocythaemic mice. The administration of low doses (0.1--0.5 mg/kg body wt.) of vinblastine to rabbits caused a significant increase in serum thrombopoietic activity. Higher doses of vinblastine (1--5 mg/kg body wt.) also increased the serum thrombopoietic activity, but this increase was preceded by a transient drop in the platelet count of peripheral blood. This thrombocytopenia could have been a stimulus for an increase in thrombopoietic activity, through a compensatory feedback mechanism. The vinblastine-induced increase in thrombopoietic activity was abolished by bilateral nephrectomy but not by bilateral ureteral ligation. These data suggest that kidney tissue may be a major source of the serum thrombopoietic factors.

Animals↗
PubMed1977

Imidazole carboxamide (DTIC) in the treatment of advanced lymphomas. Efficacy of DTIC in cases which fail to respond to conventional chemotherupetic combinations.

15 patients with malignant lymphomas (stage III B or IV) who had become resistant to previous combination chemotherapy were treated with DTIC. The drug was administered intravenously as a single agent in doses of 300 mg/m2 on 5 consecutive days, once a month. The results demonstrate good responses in Hodgkin's disease, while in non-Hodgkin's lymphomas only incomplete and short remissions or failures were recorded. The only untoward side effects were nausea, vomiting and pain in the vein during the injection.

Adult↗