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Biomedical subjects

L E Edqvist

Publications and source records attributed to L E Edqvist.

At least 73 records · Page 4Linked to original sources
PubMed1982

Progesterone, prostaglandin F-2 alpha, PMSG and oestrone sulphate during early pregnancy in the mare.

Blood samples from 4 mares during the late luteal phase, oestrus, early pregnancy and up to about 150 days of gestation were analysed for 15-keto-13,14-dihydroprostaglandin F-2 alpha (PGFM), progesterone, PMSG and oestrone sulphate by radioimmunoassays. During the late luteal phase, at the time of corpus luteum regression and decreasing progesterone levels, PGFM peaks were recorded. During early pregnancy (i.e. from mating and up to about Day 30) no such peaks were detected. After mating the progesterone levels increased and remained high throughout the observation period. During the oestrous cycle PMSG levels tended to reflect gonadotrophic activity because of high cross-reaction with horse LH and horse FSH. During early pregnancy PMSG levels increased at around Day 40, reaching maximum values between Days 50 and 80, when the blood concentration was 1000 times higher than values during oestrus. Oestrone sulphate concentrations increased about 3-fold during oestrus and about 10-fold at the peak of PMSG. After about Days 70-75 of pregnancy the levels of oestrone sulphate increased further and values of greater than 250 nmol/l were reached around Day 100.

Animals↗
PubMed1981

Peripartal changes of estrone, progesterone and prostaglandin in the water buffalo.

The peripheral blood plasma concentration of estrone, progesterone and 15-keto-13, 14-dihydroprostaglandin F2alpha (PGF2alpha metabolite) were determined by radioimmunoassay techniques during the peripartal period in 5 buffalo cows belonging to a river type breed. Estrone levels started to increase from below 200 pg/ml about 15 days prior to parturition, and reached high concentrations (400-750 pg/ml) during the last 5 days of pregnancy. The estrone concentration decreased to baseline levels after delivery. The concentration of progesterone fluctuated between 800 and 2000 pg/ml until 15 days before calving and showed a gradual increase during the last 15 days of pregnancy. The progesterone levels declined abruptly on the day of calving and remained below 100 pg/ml for up to 60 days post-partum. Increased levels of the prostaglandin metabolite were recorded from 15 days prior to parturition with further increases occurring during the last 3 days of pregnancy. PGF2alpha metabolite levels declined gradually after parturition, reaching base line levels 15-20 days after calving.

Journal Article↗
PubMed1981

Androgen and glucocorticoid receptors in porcine skeletal muscle.

The presence of free androgen and glucocorticoid receptors was demonstrated in the rectus femoris muscle of the pig. No detectable free androgen receptors were observed in intact male pigs. Androgen receptor characteristics in castrates and gilts were related to the growth rate of the lean meat in the ham. The amount of free androgen receptor was less (P less than .05) and the androgen was more tightly bound to its receptor (P less than .05) in pigs with above-average ham growth. Moreover, a higher DNA content (P less than .01) was also found in these pigs, giving a lower (P less than .05) protein to DNA ratio. The anabolic action of androgens is likely to be mediated via androgen receptors in skeletal muscle cytosol. The amounts of free glucocorticoid receptors found were influenced by the pH of the cytosolic fraction. The relationships between cytosolic pH and both the amount of glucocorticoid receptor (positive; P less than .01) and plasma levels of cortisol (negative; P less than .05) might reflect the stress to which the pigs are exposed at slaughter.

Animals↗
PubMed1980

On the control of prostaglandin release during the bovine estrous cycle. Effects of cloprostenol injections.

The study comprise seven cows which were injected i.m. with 500 microgram of a synthetic prostaglandin analogue (cloprostenol) at different stages of their estrous cycles. Peripheral blood plasma levels of progesterone and the main blood plasma metabolite of prostaglandin F2 alpha, 15-keto-13,14-dihydroprostaglandin F2 alpha were determined. The injection of cloprostenol initiated luteolysis in all cases as evidenced by decreasing progesterone levels and occurrence of heat. In two animals injected on days 6 and 12, respectively, of the estrous cycle no release of endogenous prostaglandin F2 alpha was found. In animals injected on day 13 and 15 of their estrous cycles, respectively, a minor but sustained release of prostaglandin F2 alpha was found. In three animals injected on days 17, 17 and 19 of their estrous cycles, respectively, the endogenous release of prostaglandin F2 alpha had already started and no specific effect attributed to the injection of cloprostenol could be observed. It is concluded that the injection of cloprostenol initiates luteolysis with subsequent heat and ovulation. The release of endogenous prostaglandin F2 alpha occasionally seen in conjunction with the induced luteolysis is different and less pronounced as compared to the release seen during normal luteolysis in the cow.

Animals↗
PubMed1980

Effects of HCG with oestradiol benzoate on the luteal function in gilts.

Human chorionic gonadotrophin (HCG) combined with oestradiol benzoate was tested for induction and synchronization of heat in gilts. Judging from the progesterone levels in the blood, several of the gilts were already exhibiting spontaneous oestrous cyclicity on the day of treatment. Only gilts with low blood progesterone levels on the day of treatment showed standing oestrus within the expected time. On the basis of the results a second trial was carried out to elucidate the influence of the hormone compound on the ovarian activity in gilts during the luteal phase.

Animals↗