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Biomedical subjects

L E Gedymin

Publications and source records attributed to L E Gedymin.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Morphological characteristics of reparative process in tuberculous inflammation].

The morphological analysis of the reparative process in the involvement foci and adjacent pulmonary tissue in patients with pulmonary tuberculosis and experimental animals during intensive focal resolution has revealed a change in the cellular composition: epithelioid cells are replaced by macrophages, T-lymphocytes SD8 (suppressors) by those CD4 (helpers); actively synthesizing fibroblasts and vascular endothelium appear in the area of specific inflammation instead of the cells that have a decreased collagen-forming function. The employment of various methods for stimulation of cellular reactions (lasers, electromagnetic irradiation of the mm range - MM waves, the complex of cytokines) leukinferon enables one to alter the qualitative and quantitative cellular composition of granulomas, the rate of metabolic processes and the differentiation of cells, as well as to examine the regularities of reparative reactions more effectively and more purposefully. The perfocally adjacent pulmonary tissue wherein the diseased parenchyma and stroma recover has been ascertained to be also involved into the reparative process.

Animals↗
PubMed1993

[Tuberculous periodontitis].

Peridental foci of infection (PFI) in periodontitis in 113 patients with pulmonary tuberculosis were evaluated clinico-morphologically with regard to mycobacterial populations. Vegetation in PFI of bacterial, bacterial and L-form M. tuberculosis (37.2%) was associated with clinically inapparent periodontitis symptoms, formation of large and middle-size PFI with destruction and foci of productive tuberculous inflammation. Persistent L-forms of M. tuberculosis (59.3%) brought out a symptomless periodontitis with small and middle-size PFI, manifest immune or minor tuberculous inflammation, reparative processes. The findings suggest that PFI in tuberculous patients' periodontitis is a form of extrapulmonary tuberculosis.

Adult↗
PubMed1993

[Changes in the fibronectin level of the blood and bronchoalveolar lavage fluid in experimental tuberculosis in guinea pigs].

The study was made of 64 guinea pigs with induced generalized tuberculosis which underwent no treatment, 60 infected animals receiving chemotherapy 2 weeks after the inoculation and 16 healthy animals. Citrate plasma and bronchoalveolar lavage (BAL) fluid of all the animals was examined for fibronectin (FN) concentrations using ELISA. The measurements were made 1 week, 1 and 2 months following inoculation and 2 weeks, 1.5 and 2.5 months after the start of the treatment. Histological investigations of the lungs, liver and spleen were performed at the same terms. It was established that for generalized tuberculosis developing spontaneously FN changes are characterized by multidirectional trends, seen more markedly at the terminal stage of the process. A long-term specific therapy was associated with rising FN levels in the blood and BAL fluid.

Albumins↗
PubMed1992

[Functional morphology of the lungs in patients with tuberculosis and diabetes mellitus].

The lungs of 20 patients (between the ages of 14 and 46 years) with tuberculosis and type I diabetes mellitus were subjected to a morphological examination with the help of a light and electron microscope. Thirteen patients were operated on for fibrous-cavernous tuberculosis and 7 for pulmonary tuberculoma. A duration of the concurrent diseases was 3 to 10 years (5.5 years, on average). All patients had a serious form of diabetes mellitus. The combined affection was characterized by a progressive course of tuberculosis with involvement of bronchi in the process. Specific features of tissue reactions pertinent to this combined pathology were revealed which comprised defective defense mechanisms (alveolar macrophages, type II alveolocytes and fibroblasts in the form of their dystrophy) generalized affection of pulmonary vessels, intensive fibre formation and disorganization of the forming connective tissue, which has a bearing on the development of the pathological process.

Adolescent↗
PubMed1991

[Intra-dental route of experimental tuberculosis infection].

A total of 13 dogs weighing 13-15 kg were infected by intra-dental route with the tuberculosis mycobacterium strain H37R in a dose of 0.5 ml in the 5th dilution according to a turbidity standard. Two dogs were given intravenously the same dose of tuberculosis mycobacteria and they formed a control group. The observation varied from 10 days to 5 months. It was found tuberculosis development in intradental contamination could be attended by generalized specific affection of the viscera and development of a "minor" tuberculosis inflammation in the peridental tissues.

Animals↗
PubMed1990

[Prostaglandin levels in the lung tissue of guinea pigs with tuberculosis treated with antitubercular drugs and indomethacin].

An experiment was carried out on 135 guinea-pigs (21 were used as controls and the rest subcutaneously infected with virulent M. tuberculosis culture. The latter were divided into 4 groups depending on the treatment regimen. The experiment was conducted for 3 months. The content of prostaglandins (PG) E and F2 alpha in the lung tissue was measured by radio-immunoassay. It was found that a spontaneous development of tuberculosis in the guinea-pigs was accompanied by phasic changes of PG. The period of a relative resistance was followed by an initial short-term drop or PGF2 alpha and a subsequent decrease of PGE/PGF2 alpha. During a swift progression of inflammatory and necrotic changes there was a congruous growth of both types of PG, with PGF in abundance. In the preterminal period of the disease, an irrepressible PGE growth was observed. With chemotherapy, the PG content in the lung tissue was normalized not later than in a month. Indomethacin++ used at the beginning of infection before chemotherapy has a persisting aftereffect as a consecutive drop of PGE and PGE/PGF2 alpha at first and PGF2 alpha later on. The administration of indometacin concurrently with chemotherapeutic drugs produced a similar, but less marked effect. The prescription of indometacin both at early stages and simultaneously with chemotherapy could improve a morphologic outcome of the disease, stimulating proliferative reactions of the lymphoid system, as well as resolution and repair processes.

Animals↗
PubMed1990

[Pulmonary histiocytosis X].

Morphologic studies of the lungs of 61 patients aged 15-62 years with pulmonary histiocytosis X revealed a different morphologic picture in relation to the duration of the disease. The most prevalent were primary and chronic forms characterized by the presence of histiocytic granulomas of varying size with blue-green inclusions, eosinophilia and corpuscles X in the macrophage cytoplasm. As the process progressed, fibrobullous changes occurred in the lungs. An open biopsy of the lungs and testing of the lavage macrophages for corpuscles X appears to be more informative and safe for the morphologic diagnosis of histiocytosis X.

Adolescent↗
PubMed1986

[Morphofunctional status of the lungs in extrinsic allergic alveolitis].

Morphological changes in the lungs of 57 patients suffering from exogenous allergic alveolitis (EAA) are described, the majority of patients had a contact with birds. Interstitial edema, microcirculation disturbances and abundant lymphoid infiltration were observed at an acute initial stage of the disease in 5 patients. Sarcoid-like granulomas in the lung interstitium and bronchiolar wall were found at a subacute stage of the disease in 10 patients along with edema, microcirculatory disturbances and lymphoid infiltration. Predomination of fibrosis with a deformation of all lung structures were observed in 42 patients with a chronic course of the disease.

Adult↗