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Biomedical subjects

L F Marchenko

Publications and source records attributed to L F Marchenko.

At least 19 recordsLinked to original sources
PubMed2002

[Correlation between endemic iodine deficiency and radiation-induced thyroid cancer in children and adolescents].

A correlation between iodine excess and deficiency, on the one hand, and excessive relative risk (ERR) of thyroid cancer in children and adolescents following Chernobyl disaster, on the other, was investigated in a cohort of 119,785 patients born in 1968-1986. Thirty-four cases of thyroid cancer were registered within 12 years after the accident. Tumor-promoting effect of iodine deficiency was established. The ERR of thyroid cancer in the young patients suffering from severe iodine deficiency was almost twice as high as in healthy subjects.

Adenocarcinoma, Follicular↗
PubMed1998

[The effect of the laser irradiation of the blood on its lipid and phospholipid components in diabetes mellitus].

Study results of the laser irradiation impact on the blood lipid and phospholipid components and membrane erythrocyte in patients with diabetes mellitus and pyo-necrotic injuries of lower extremities when treated by laser intravenously or epicutaneously. The results prove, that the laser irradiation of low intensity favourably affects the blood components in a complex treatment of diabetes mellitus. Intravenous irradiation positive dynamics are more easily observed.

Blood↗
PubMed1991

[Diagnostic value of detection of blood levels of lactate, pyruvate and 2,3-diphosphoglycerate in children with diabetes mellitus].

Measurements were made of lactate, pyruvate and 2,3-diphosphoglycerate in 69 children admitted to the hospital in a state of diabetic ketoacidosis of different intensity. Depending on the intensity of metabolic abnormalities, the content of lactate and pyruvate was found to be increased, whereas that of 2,3-diphosphoglycerate to be lowered. Measurements of the content of lactate and the lactate/pyruvate ratio enables carrying out differential diagnosis between the ketoacidotic and lactacidotic varieties of diabetic coma.

2,3-Diphosphoglycerate↗
PubMed1991

[Study of unsaturated plasma lipids in children with diabetes mellitus].

The determination of unsaturation of lipids contained by the blood serum and cell plasma membranes, which depends on the total amount of double bonds (DB) in unsaturated fatty acids is a new and promising method of estimating lipid metabolism in diabetes mellitus. Unsaturation was determined by ozonization. 91 children aged 7 to 15 years were examined. The control group included 10 healthy children of the same age. The standardized values of unsaturation were delimited in the healthy children, which amounted to 260 +/- 20 conventional units. A relationship was discovered between DB and the degree of compensation together with the disease standing. Comparative analysis of blood DB and the lipid spectrum demonstrated that the high values of unsaturation correlate with elevated concentrations of free cholesterol, nonesterified fatty acids, cholesterol esters, pre-beta-LP, beta-LP and triglycerides.

Adolescent↗
PubMed1991

[Comparative aspects of the changes in lipid metabolism indicators in lymphocyte and erythrocyte membranes in children with diabetes mellitus].

Lipid metabolism in lymphocytes was compared to that in the blood serum and red blood cells. 50 children aged 7 to 15 years suffering from insulin-dependent diabetes mellitus (IDDM) in the phase of decompensation without ketosis were examined. The patients were treated at hospital. 12 healthy children of the same age made up the control group. The changes in the lipid composition of red blood cells were shown to follow "passively" the changes occurring in the lipid composition of the blood serum. On the contrary, the changes in the lipid composition of lymphocyte membranes in IDDM are of "active" nature and may be caused by the displacement of the metabolic changes in lipid to a new pathological level. The changes in the lipid composition of lymphocyte membranes, seen in the phase of IDDM decompensation are one of the main factors responsible for the lowering of lymphocyte function that determines the formation of immunodeficiency followed by the superaddition of infectious diseases.

Adolescent↗
PubMed1990

[State of the neuroendocrine system in children with congenital defects of development dependent on changes in the karyotype].

Forty children with multiple congenital developmental abnormalities (MCDA) without any visible changes in the karyotype and 36 MCDA children having visible changes in the karyotype were examined for the status of the neuroendocrine system. The children's age ranged from 10 days to 3 years. The children with MCDA manifested dysfunction of the neuroendocrine system, determined by the blood serum content of a number of hormones of the pituitary and the insular apparatus of the pancreas. The neuroendocrine dysfunction appeared to be in a reverse relationship to the intensity of the clinical signs (organic damage to the nervous system, delayed physical development, developmental abnormalities and minor developmental abnormalities). It manifested itself to the greatest degree in patients with numerical and structural chromosomal rearrangements and might be related to morphological or functional failure of the neuroendocrine system on the whole or of one of its components.

Age Factors↗
PubMed1990

[The indices of the blood serum lipid and hormonal spectra in patients with diffuse neurodermatitis].

Thirty-two female patients suffering from neurodermatitis were examined. Increased hydrocortisone level and reduced estrogen concentration in the blood serum were observed during exacerbation of the condition. During remission these parameters normalized. Exacerbations were associated with marked dyslipidemia at the expense of elevated concentrations of triglycerides, free cholesterol, low-density lipoproteins in the blood serum; these parameters also showed a tendency to normalization during remission. A correlation could be traced between hormonal imbalance and disturbances of lipid metabolism regulated by these hormones. The authors emphasize the necessity of correcting dyslipidemia during exacerbation of diffuse neurodermatitis.

Adolescent↗