Comparative investigation of indices of lipid peroxidation and blood lipid unsaturation was carried out in 91 pediatric inpatients (aged 7 to 15) with type I diabetes mellitus and in 10 controls of the same age. Activation of free radical lipid peroxidation was shown to occur in children with diabetes mellitus. A degree of compensation of diabetes did not influence the level of hydroxyperoxides (HP) and final decay products (FP) of lipid peroxidation. In ketoacidotic decompensation HP and FP concentrations in the patients were increased as compared to those in the controls by 284 and 255%, respectively. At the same time children who were admitted in coma, demonstrated low values of blood lipid unsaturation. Insulin therapy (irrespective a drug dose) was accompanied by a 1.8-2-fold increase (p less than 0.05) in a HP level as compared to control values. Change in the level of lipid unsaturation depended upon a daily dose of insulin. In diabetes over 1 year different types of changes in lipid peroxidation and unsaturation were detected, and individual differences in their levels required a differentiated approach to therapeutic tactics.

Adolescent↗

PubMedDate not supplied

[Comparative evaluation of the lipid metabolic indices of children with a hereditary predisposition for diabetes and in manifest diabetes mellitus].

The paper is concerned with the results of investigation of serum lipid, phospholipid and lipoprotein spectra in 31 sibs, 100 children with diabetes mellitus (DM), 83 women in birth with DM and their fetuses. This study showed a necessity of planned investigation of sibs not only for the detection of glucose tolerance but also of primary and secondary dyslipemia. In children with manifest DM the ratio of lipid, phospholipid and lipoprotein fractions was disturbed and depended upon a degree of compensation, a period of disease and a dose of insulin. The type of changes in the women in birth with DM was the same as during pregnancy: there was an increase in the concentration of total lipids and some of their fractions: nonesterified fatty acids, triglycerides, cholesterol, and atherogenic lipoproteins. Liposynthetic activation observed in infants born to DM mothers, was associated with the metabolic effects of insulin, of which a degree of hypersecretion seemed to determine the type of lipidograms.

Adolescent↗

PubMedDate not supplied

[Characteristics of the shaping of practical skills and habits in oral surgery in 3d- and 4th-year students of a dentistry department at a polyclinic].

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Internship and Residency↗