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Biomedical subjects

L F Panchenko

Publications and source records attributed to L F Panchenko.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

[Intracellular peroxidation processes in chronic alcohol intoxication].

The data available in literature concerning the induction of lipid peroxidation (LP) with chronic alcohol administration are systematized. LP can be considered as one of the main processes leading to cellular membrane damage. The cytotoxic activity is attributed not only to the free radicals but also to the final products of the lipid hydroperoxide decomposition, such as malonic dialdehyde and 4-hydroxyalkenals. Data about antioxidative defence enzymes (glutathione peroxidase and transferase, catalase superoxide dismutase) and less investigated protein factors which inhibit LP are summarized; particular attention is paid to changes in their activity during chronic alcoholization. Molecular mechanisms underlying the LP stimulation in the liver tissue against a background of ethanol ingestion are analyzed. New data are presented on the role of peroxisomes in the development of alcohol cardiomyopathy.

Alcoholism↗
PubMedDate not supplied

[Cyclic nucleotides in experimental uveitis].

Content of cyclic nucleoside monophosphates was decreased in all the eye tissues in experimental toxico-allergic uveitis as well as penetration of cAMP into the fluid of anterior chamber of the eye. In various eye departments a dissimilar decrease of cyclic nucleotides occurred that had to be taken into consideration in a medicine prescription.

Animals↗
PubMedDate not supplied

[Enkephalin convertase activity in various brain regions of rats during alcoholic intoxication].

Effects of single and chronic administrations of ethanol into rats on activity of soluble and membrane-bound forms of enkephalin convertase were studied in various parts of brain. Regional alterations in the patterns studied dependent on duration of alcoholization were observed. Enkephalin convertase appears to be involved in development of tolerance to alcohol.

Alcoholic Intoxication↗
PubMedDate not supplied

[Superoxide dismutase activity in the blood of children with iron deficiency anemia].

Activity of superoxide dismutase was studied in blood of children with various types of iron deficiency anemia. The enzymatic activity was increased in all the types of iron deficiency anemia studied (typical form, infectious anemia of premature children). This increase was especially distinct, when calculation was made per 1 mg of hemoglobin or 1 billion of erythrocytes. Alterations in superoxide dismutase activity and in content of blood hemoglobin were reciprocal in the anemias studied. Correlation was observed between the alteration in the enzymatic activity and a decrease in content of hemoglobin in prematurely born children with anemia.

Adolescent↗