TRH on rat conditioned avoidance behavior: interaction with brain catecholamines.
TRH (10 micrograms) intracerebroventricularly injected improves the acquisition of a two-day avoidance conditioning. This effect is partially antagonized by pretreatment IP with alpha-methyltyrosine (60 mg/kg) or disulfiram (300 mg/kg). L-DOPA (100 mg/kg) administered IP 2 hr after alpha-MT partially restores the facilitatory effect of the hormone. The possible roles of brain catecholamines on the behavioral effect of TRH are analysed. Other tentative mechanisms of action are also discussed.
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