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TRH on rat conditioned avoidance behavior: interaction with brain catecholamines.

S Mora·A G Nasello·L Fieschi
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Abstract

TRH (10 micrograms) intracerebroventricularly injected improves the acquisition of a two-day avoidance conditioning. This effect is partially antagonized by pretreatment IP with alpha-methyltyrosine (60 mg/kg) or disulfiram (300 mg/kg). L-DOPA (100 mg/kg) administered IP 2 hr after alpha-MT partially restores the facilitatory effect of the hormone. The possible roles of brain catecholamines on the behavioral effect of TRH are analysed. Other tentative mechanisms of action are also discussed.

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AnimalsAvoidance LearningBrain ChemistryCatecholaminesDihydroxyphenylalanineDisulfiramInjections, IntraventricularMaleMethyltyrosinesRatsThyrotropin-Releasing HormoneJournal Article

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S Mora, A G Nasello, L Fieschi. 1980. TRH on rat conditioned avoidance behavior: interaction with brain catecholamines.. https://doi.org/10.1016/0091-3057(80)90134-3

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