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Biomedical subjects

L Franke

Publications and source records attributed to L Franke.

44 records · Page 3Linked to original sources
PubMed1978

[Separation of enriched synaptosomes, synaptic vesicles and synaptic plasma membranes].

A rapid and simple method is described for separation of intact synaptosomes, synaptic plasma membranes and vesicles. Two synaptosome fractions were obtained by modified differential centrifugation. The rate zonal zentrifugation in a linear sucrose gradient (very low density) is suitable to obtain fractions highly enriched in synaptic plasma membranes and vesicles. Examination of the prepared fractions was done by enzyme marker activities and electron microscopy

Adenosine Triphosphatases↗
PubMed1975

The effect of D-penicillamine of the skeletal development of rat foetuses.

Rats received 20, 50 or 100 mg/animal D-penicillamine i.p. twice daily on days 15, 16, 17, 18, and 19 of gestation, i.e. a total dose of 200, 500 resp. 1000 mg/animal. At all dosages the number of fetal resorptions did not increase significantly. Weight of the 20 day old embryos as well as length of the long bones in the extremities in the 100 mg-group showed a significant decrease. Numerous skeletal alterations could be observed in the 1000 mg-group such as absence, deformations or incomplete mineralisation of bones. Light microscopic examinations revealed an inhibition of the ossification as well as a decrease of number and size of the trabecula and of the thickness of the perichondrial bone sheath. A swelling of the collagenous fibrils can be demonstrated with the electron microscope. The first apatite crystals aggregate in collagen-free areas. The fusion of these aggregates to homogenously mineralized trabecula is inhibitied. In contrast to bones from untreated embryos, mineralized areas show varying content of collagen and apatide crystals. A regular spatial relationship between apatite crystals and collagenous fibrils does not develop. These findings show that even after the so-called "critical period" malformations can be pproduced by substances which disturb synthesis and maturation of the mesenchymal intercellular substance.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Angiological complications following high tibial head correcting osteotomy--a case report].

Vascular complications following orthopedic procedures at the lower extremity are mainly thrombotic or thromboembolic events. Damages to vascular structures during operations close to the knee joint, like injuries of the popliteal artery, are extremely rare and receive a reserved consideration in the evaluation of postoperative complications. The extent of the vessel injury affects the grade of clinical symptoms-from acute arterial bleeding as far as slowly developing disturbances of haemodynamic, with effects to the different functions and pattern of the concerned tissues. Arterial bleeding into muscle compartments do not necessarily appear as an acute emergency, therefore it may occasionally be difficult to place the clinical symptoms into the right context of pathophysiological processes. In the present case a deep vein thrombosis of the affected extremity was initiated by a haemorrhage into the fossa popliteal and the compartments of the lower leg after injury of the popliteal artery. Subsequently a compartment syndrome, a false aneurysm of the popliteal artery and an arteriovenous fistula from popliteal artery into a lower leg vein developed.

Aneurysm↗