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Biomedical subjects

L Fumagalli

Publications and source records attributed to L Fumagalli.

At least 109 records · Page 6Linked to original sources
PubMed1977

Radiopaque contrast media XXXI-Glucoside conjugation of iodophthalein in rabbit.

Report is given on the identification of the metabolites of the iodophthalein sodium (TIP) in rabbit. After i.v. administration two meabolites (S1 and S2) were excreted mostly in the bile, but both were also found in the urine. The TIP glucoronide (S1) is formed in much greater yield than the glucoside (S2). This latter is a further example of glucoside conjugation in mammals.

Animals↗
PubMed1976

Radiopaque contrast media. XXXIV - Derivatives of omega-(3-amino-2,4,6-triiodophenoxy)alkoxyalkanoic acids.

A series of new oral cholecystographic contrast media with promising characteristics is obtained after the study of the relationships among molecular structure, tolerability, biliary and urinary excretion, as well as gallbladder opacification. The synthesis of this series is described. Particularly good tolerability, high biliary excretion and excellent roentgenographic findings were achieved with compound (IX) (iopronic acid). This contrast agent was selected for a more detailed study of toxicology, pharmaco-kinetics, metabolism and experimental radiology.

Animals↗