Biomedical subjects
Publications and source records attributed to L G Wiman.
Post mortem studies of rat lungs showed that application of fibrin sealant augments the tensile strength of the lung/visceral pleura by approximately 100 mmHg, thus impeding air leakage.
In the County of Stockholm, changes in cigarette consumption were followed within 1-2 years by similar changes in the incidence of spontaneous pneumothorax.
The degree of physical activity at the onset of spontaneous pneumothorax was evaluated retrospectively in 219 patients, predominantly smokers who had had this disease for the first time. More than 87% had been inactive at the onset of the symptoms. Moderate exertion was recorded in only 2%, and no patients were exerting themselves heavily when the symptoms began. The occurrence of spontaneous pneumothorax was unevenly (p less than 0.001) distributed over the day. In 9% the symptoms had their onset during quick movement--such as fastening a seat belt--without any effort. The inactivity or low activity at the onset of symptoms of spontaneous pneumothorax suggests that this condition is unrelated to muscle effort.
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A programme of increased physical activity and self treatment based on the forced expiration technique was introduced to 14 adolescent patients with cystic fibrosis, diagnosed since infancy or early childhood, who had gastrointestinal and pulmonary symptoms. Twelve patients who fulfilled the one year programme had unchanged clinical conditions, pulmonary function tests, and chest x ray films. There was a significant improvement in oxygen pressure correlated to the period of increased physical activity. Other blood gas variables, including pH, standard bicarbonate, and base excess, also indicated significant changes, mainly during exercise. The study shows that daily physical activity improves the pulmonary gas exchange and that self treatment combined with physical activity is as efficient as conventional physiotherapy.
This study is based on investigations of 11 nonsmokers with healed spontaneous pneumothorax. Physiologic, scintigraphic and radiologic examinations were performed to determine whether they had any impairment of overall or regional lung function. Posteroanterior and lateral chest radiographic examinations revealed no abnormality. Forced expirographic study was normal, but the residual volume was increased. Ventilation was impaired and perfusion decreased in the apical region of the lungs, also the most common location of spontaneous pneumothorax. Findings are consistent with the presence of regional airway obstruction, which may cause, or at least contribute to, development of this condition.
The fatty acid pattern of the phospholipids in the bronchial secretion of patients with cystic fibrosis (CF) showed an increase of the mole fraction of arachidonic acid (AA) in most phospholipid classes compared to normals. Increase of AA in some classes was also found in patients with chronic bronchitis and in patients chronically colonized with Pseudomonas aeruginosa but in the diphosphatidylglycerol, lysophosphatidylethanolamine and sphingomyelin phospholipids, high fractions of AA was found exclusively in CF patients. Arachidonic acid was found to attain the highest ratios in CF in seven of the nine major bronchial phospholipids compared to the controls. There was no difference in the ratio saturated/unsaturated fatty acids between the CF patients and the control groups. A tendency towards unsaturation of the fatty acids in the bronchial secretion seems to be characteristic of infection and inflammation but AA appears to be more markedly increased in CF. Thus, the recorded changes may be characteristic for CF and not secondary to infection and/or inflammation in general, nor to P. aeruginosa colonization.
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The nuclear DNA content in morphologically identified tumor cells was analyzed in 4-micron histologic sections from 58 patients with lung carcinoma who survived for at least five years. Thirty-three of the carcinomas were invasive squamous bronchial carcinomas and 25 were pulmonary adenocarcinomas. In all squamous carcinomas, the majority of tumor cells were found to exhibit DNA values exceeding the normal tetraploid and/or diploid region. In contrast, some of the pulmonary adenocarcinomas were found to be composed of a majority of tumor cells with DNA values in the normal diploid region. The results indicate that invasive squamous bronchial carcinomas, in general, are tumors with aneuploid DNA patterns indicative of a high malignant potential and that malignancy grading based on DNA measurements does not add any significant prognostic information to that obtained by morphologic diagnosis.
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The population living within a small area around a sulphite pulp factory in Northern Sweden was studied with regard to chronic obstructive lung disease. In persons in the age group 20-64 years the prevalence of bronchial asthma was found to be 3.0% for males and 3.2% for females. These figures correspond closely with previous studies in the Central and Southern Sweden. In the same age group the prevalence of chronic bronchitis was 2.8% for males and 1.0% for females, i.e. not differing much from that of other parts of Sweden. These findings, however, were far removed from the high prevalence of chronic bronchitis reported from Northern Finland, viz. 28.2% in males and 5.8% in females. The difference is probably attributable to differences in diagnostic criteria. In this study, those sulphite pulp factory workers who smoke seemed to constitute a population running a high risk of contracting chronic bronchitis.
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