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Biomedical subjects

L Henriksson

Publications and source records attributed to L Henriksson.

At least 37 records · Page 2Linked to original sources
PubMed1987

Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study.

In a randomised, double blind, long term, crossover study 1 g twice daily of methenamine hippurate was compared with placebo for its preventive effect on recurrent attacks of acute cystitis. Methenamine hippurate and placebo were interchanged every six months for two years. During one of the years patients took 250 ml extra fluid every morning and evening. Out of 21 enrolled patients, 14 completed the first year and 13 both years of treatment, which permitted the evaluation of 27 patient years. There were 52 episodes of acute cystitis caused by reinfection: 41 occurred during placebo treatment and only 11 during the methenamine hippurate regimen (p less than 0.01). Extra fluid intake did not reduce the incidence of acute cystitis, nor did it reduce the effect of methenamine hippurate. Methenamine hippurate is an effective prophylactic agent against recurrent acute cystitis and has the advantage of not inducing cross resistance to conventional antibiotics.

Acute Disease↗
PubMed1987

Serum CRP in the diagnosis and treatment of pelvic inflammatory disease.

The usefulness of serum C-reactive protein (CRP) measurement was studied in a population of 152 patients admitted to a gynaecological emergency unit. Fifty-one of 55 patients with PID had raised (over 10 mg/l) (13-270 mg/l) CRP levels with a mean of 76.1 mg/l. CRP was elevated (12-40 mg/l) in 2 of 18 patients with threatened abortion with successful outcome, in 8 of 28 patients with incomplete abortion, and in 2 of 16 patients with ectopic pregnancy. Furthermore, 6 of 35 patients with noninfectious disorders (ovarian cyst, uterine fibroid, unexplained pelvic pains) had slightly elevated (12-59 mg/l) CRP levels. Thus, in this series a CRP greater than 10 mg/l had good sensitivity (93%) and specificity (83%) in the diagnosis of PID. Furthermore, CRP levels became normal much sooner than did erythrocyte sedimentation rate following effective antibiotic therapy, suggesting that it is useful in monitoring therapeutic response.

Adult↗
PubMed1985

Ambulation versus oxytocin in protracted labour: a pilot study.

We compared ambulation with oxytocin in the treatment of protracted labour with a randomized, controlled trial of 57 patients. Sixty percent of the women in the ambulant group delivered their babies without oxytocin. In the ambulant group, the mean length of the second stage of labour was shorter and the women themselves held relatively positive views on their experiences. In the oxytocin group, on the other hand, the women experienced stronger contractions before pushing and also suffered from more excessively strong contractions. Our trial included too few women to judge which treatment is better for the infant's health. Nevertheless, the women's opinions and the quality of their contractions demonstrate that more attention should be paid to ambulation as a treatment for protracted labour.

Adult↗
PubMed1984

Angiographic estimation of poststenotic jet kinetics in aortic valve stenosis.

The poststenotic jet phenomenon in aortic valve stenosis observed during angiography was studied by a kinetic model. The model allowed to estimate the linear momentum and the kinetic pressure of the jet, which were found to correlate to the poststenotic width of the ascending aorta indicating that the degree of poststenotic widening may be due to the pressure release from the jet.

Adult↗
PubMed1984

Detectability of intraperitoneal fluid by ultrasonography. An experimental investigation.

The detectability of intraperitoneal fluid was investigated by ultrasonography following injection of physiologic saline in conjunction with hysterosalpingography in 40 patients. It was invariably possible to identify 10 to 15 ml fluid in the pouch of Douglas with the patient in supine position and in Morison's pouch after Trendelenburg and right decubitus position. Ultrasonography is superior to conventional radiography for detection of minor intraperitoneal fluid.

Adult↗
PubMed1983

Torsion in femoral fractures in childhood. A longitudinal investigation.

A photogrammetric method developed for measurement of femoral neck anteversion was used to evaluate the torsion in 28 femoral fractures sustained in childhood and treated conservatively. Spontaneous correction of the initial torsion of 10 degrees to 30 degrees to less than 10 degrees was the rule in a growing femoral bone within 5 to 10 years after trauma.

Adolescent↗
PubMed1983

The effect of midodrine and its active metabolite ST 1059 on the human urethra in vitro and in vivo.

The directly acting alpha-receptor agonist midodrine is active through its metabolite ST 1059. The effects of ST 1059 were investigated in vitro on strips of human urethra and on small human omental arteries. ST 1059 was as potent as noradrenaline on the isolated urethra, but had only 40% of noradrenaline's maximum activity. In omental arteries noradrenaline was at least ten times more potent than ST 1059 which only had about one fourth of noradrenaline's maximum activity. Compared to its effect on the vessels ST 1059 was ten times more effective on the urethra, whereas noradrenaline was slightly more effective on the vessels than on the urethra. Thus, in vitro St 1059 exhibited some selectivity for urethral alpha-receptors. When midodrine was given to 13 female patients with stress incontinence in the doses 2.5 mg and 5 mg x 3 for two weeks, only two had a positive urethral closure pressure during treatment and were subjectively improved. There were no effects on blood pressure and heart rate; one patient complained of pilo-erection. Two further patients received 7.5 mg x 3 for two weeks; both were subjectively improved but complained of pronounced pilo-erection. Only one of them had a positive urethral closure pressure during treatment. Blood pressure or heart rate did not change. Although it cannot be excluded that midodrine can increase intraurethral pressure with minor effects on blood pressure, it seems as the doses needed cause pilo-erection to an extent that limits the clinical usefulness of the drug.

Adult↗
PubMed1982

The unstable female urethra.

Four hundred forty-seven patients with urinary incontinence were examined at the outpatient clinic and then referred to urodynamic investigation by urethral pressure profile measurement and simultaneous urethrocystometry. On urodynamic investigation, 55 patients showed signs of an unstable urethra (momentary variations in urethral pressure exceeding an amplitude of 15 cm of water by or without registration of bladder instability). Urethral instability was found in 15 patients with stress incontinence, in 23 patients with urge incontinence, and in 13 patients with combined stress and urge incontinence (i.e., signs and symptoms of both stress and urge incontinence). In four patients, urethral instability was the only pathologic finding when the recordings were made. From the pressure recordings, three types of urethral instability could be recognized: type 1, relatively small fluctuations in the urethral pressure at large bladder volumes; type 2, relatively large variations in urethral pressure with frequent decreases in the pressure, often combined with signs of unstable bladder; type 3, marked variations in the urethral pressure which appeared already at the start of urethrocystometry, i.e., at low bladder volumes. The variations in urethral pressure prevailed during the whole recording procedure, whereas bladder pressure was completely stable at all times.

Female↗
PubMed1982

Bedside ultrasound diagnosis of residual urine volume.

A hand-held real-time ultrasound scanner was used for the estimation of bladder volume in the hope of eliminating unnecessary postoperative catheterizations. In 11 women, the bladder was filled stepwise and scans were done at volumes of 0, 50, 100, 150, and 200 ml, 50 ml being chosen as the minimum volume for clinically significant residual urine. The method was then used in 43 examinations on 26 patients, 24 of whom had had a gynecological operation. There were only three mistakes: once a residual urine volume of more than 50 ml was missed, and twice the scan wrongly suggested a residual urine volume of more than 50 ml.

Adult↗
PubMed1982

Ultrasound assessment of liver veins in congestive heart failure.

The width of the liver veins was measured using ultrasound in 40 normal subjects and in 29 patients with congestive heart failure with and without pleural effusion. The liver veins were significantly wider in the patients, and the widest veins were found in those with pleural effusion. The presence of pleural effusion indicates that right heart failure, causing dilatation of liver veins, is added to pre-existing left heart failure.

Aged↗
PubMed1981

Postpartum incontinence.

From a questionnaire survey dealing with urinary incontinence during pregnancy and after childbirth 62 women were randomly selected. These women underwent simultaneous urethrocystometry including urethral profile measurement 7--14 days after parturition. From the case history two groups of patients could be distinguished. One group consisted of women who experienced only occasionally urine leakage after delivery. Pressure recordings in these previous patients were normal, moreover the urethral closure pressure was positive, also at cough provocations. The urethral length and pressure were similar to that found in continent females. The other group of patients reported stress incontinence of a more serious and permanent nature; the symptoms did not disappear after delivery. In all these women negative urethral closure pressures were recorded at cough provocations and simultaneously leakage of urine from the urethra was observed. In addition the urethral length was shorter and urethral resting pressure lower than that recorded in the first group of patients. The reversible symptoms in the first group of women may be a consequence of the pressure exerted by the uterus upon the bladder at coughing combined with a hormonal relaxation of the urethral suspension. In the second group, the enduring symptoms suggest irreversible damage to the urethra and its suspension system during pregnancy.

Female↗
PubMed1981

The frequency of disorders of the lower urinary tract, urinary incontinence in particular, as evaluated by a questionnaire survey in a gynecological health control population.

Four thousand four hundred women were examined under the gynecological health control program in Malmö municipality during a period of 11 months. Nine hundred and forty-four (21 per cent) reported that they were troubled by disorders of the urinary tract. These women were given copies of a separate questionnaire, which was subsequently properly answered by 512 women. Of these, 321 (62.7 per cent) indicated urinary incontinence. From the questionnaire alone, it was difficult to characterize the different types of urinary incontinence in the patients. Thus only 42 women (8.2 per cent) seemed to suffer from genuine stress incontinence and 34 women (6.6 per cent) from genuine urge incontinence, whereas 245 (47.9 per cent) had to be characterized as "mixed incontinence". Hence, it is obvious that in several patients suffering from urinary incontinence, written or combined written and oral interviews to not produce a clear-cut diagnosis and that the etiology and treatment of incontinence in these patients may be uncertain. It is concluded that interviews with most patients suffering from urinary incontinence must be supplemented by objective recordings before a definitive diagnosis and treatment can be prescribed.

Adult↗
PubMed1980

Urethrocystometry as a routine method for the objective evaluation of women with urinary incontinence.

Over a 2-year period, 401 patients with urinary incontinence were examined at the Women's Clinics in Lund and Malmö and then investigated by urethral pressure profile measurement and simultaneous urethrocystometry. After full investigation the patients could be classified as follows: 214 (53.4%) had genuine stress incontinence, 48 (12.0%) had genuine urge incontinence, 41 (10.2%) had mixed incontinence, 20 (5.0%) had urgency-frequency, 6 (1.5%) had neurogenic incontinence, 9 (2.2%) had incontinence of uncertain aetiology, and 63 (15.7%) of the patients were apparently continent with normal urethral pressure profiles and urethrocystometrograms.

Diagnosis, Differential↗
PubMed1980

Early diagnostic signs in the development of a fallopian tube carcinoma.

A woman is presented in whom cellular atypia and signs of abnormal fibrinolysis in a jet washing caused persistent suspicion of malignancy after a benign curettage. Nearly 3 years later a fallopian tube carcinoma was diagnosed. The value of determination of biological markers of neoplasia in addition to the cytologic interpretation of uterine fluid is emphasized.

Adenocarcinoma↗
PubMed1979

Combined urethrocystometry and cinefluorography in continent and incontinent women.

Intravesical and intra-urethral pressures were recorded in 5 continent women and 10 women with urinary stress incontinence using combined urethrocystometry and cinefluorography. At rest, two types of stress incontinence could be recognized; one involved widening of the proximal urethra and the other did not. Under stress, the proximal urethra was rather mobile in the incontinent women. Artifacts caused by axial movement of the urethral microtransducer were eliminated by fixation of the catheter against the external meatus.

Adult↗