PubMed Health⌕ Search

Biomedical subjects

L J COLE

Publications and source records attributed to L J COLE.

At least 37 records · Page 2Linked to original sources
PubMed1964

(HOMOGRAFTS IN THYMECTOMIZED, IRRADIATED MICE: RESPONSES TO PRIMARY AND SECONDARY SKIN GRAFTS.)

Adult thymectomized, irradiated mice restored with syngeneic bone marrow exhibit an accelerated response toward second-set skin homografts, although the response to the primary grafts is impaired. Such mice have a long-lasting impairment (up to 223 days) of the primary response to allogeneic grafts (but not to xenogeneic grafts) and show the greatest deficiency of response toward grafts sharing the same H2 locus as the host. Thymectomy in the adult mouse is ineffective in altering a state of homograft sensitivity induced prior to irradiation.

Allografts↗
PubMed1963

THYMUS: ITS LIMITED ROLE IN THE RECOVERY OF HOMOGRAFT RESPONSE IN IRRADIATED MICE.

Adult mice subjected to thymectomy or sham thymectomy received lethal irradiation and subsequent protective infusion of syngeneic bone marrow. Thirty days later they received allogeneic and xenogeneic skin grafts. Donors of the xenogeneic grafts were rats. The thymectomized mice rejected the grafts of rat skin only slightly later than the controls did; in contrast, the time of retention of allogeneic grafts was significantly longer in the thymectomized mice.

Allografts↗