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Biomedical subjects

L J COLE

Publications and source records attributed to L J COLE.

At least 55 records · Page 3Linked to original sources
PubMed1963

DISSOCIATION OF HOMOGRAFT RESPONSE TO ALLOGENEIC VERSUS XENOGENEIC SKIN GRAFTS IN IRRADIATED MICE.

Lethally x-irradiated (C3H x DBA/2)F(1) mice were protected with syngeneic (isogenic) bone marrow and/ or prior treatment with urethan and skin grafted at various times after irradiation. The ability to reject a first-set xenogeneic (heterologous) skin graft with normal vigor returned within 92 days; the first-set response to allogeneic (homologous) grafts was still impaired 350 days after irradiation.

Allografts↗
PubMed1963

Reduced incidence of persistent chromosome aberrations in mice irradiated at low dose rates.

A marked difference was observed between the effectiveness of high and low dose rates of ionizing radiation in producing persistent chromosome aberrations in the marrow cells of mice. Clones of cells with chromosome abnormalities were present in the marrow of all the mice previously exposed to single or fractionated doses of x-rays given at a rate of 30 rad/min. The frequency of chromosome aberrations in these mice varied from 14 to 72 percent of the cells exdmined. By contrast, none of the mice exposed to continuous gamma radiation at a low dose rate (1.45 rad/hour) showed definite clones of abnormal marrow cells, and the frequency of persistent chromosome aberrations varied from zero to 8 percent in this group.

Animals↗
PubMed1963

Homograft tolerance in mice: use of urethan and sublethal irradiation.

Adult mice [CBA/J (H-2(k))], which received either a single sublethal dose of x-radiation (500 rad) or urethan plus 500 rad, were given intravenous injections of C3H/HeJ (H-2(k)) spleen or bone marrow cells (18 to 42 x 10(6) cells per mouse) or both, for 3 days. C3H/HeJ tail-skin homografts were retained (over 130 days) by these mice, whereas BALB/cJ (H-2(d)) homografts all were rejected within 33 days. Similarly irradiated or urethan-treated controls (or controls treated with a combination of both), which did not receive C3H cells, rejected both homografts. Specific homograft tolerance is induced in adult mice by this procedure.

Allografts↗