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Biomedical subjects

L Józsa

Publications and source records attributed to L Józsa.

At least 37 records · Page 2Linked to original sources
PubMed1993

Amianthoid fibres in ruptured human tendons.

So-called amianthoid fibres were identified in 17 of 460 tendons (3.7%) after spontaneous rupture. These tendons belonged to 10 men and 7 women with an age-range from 18 to 67 years. In 445 postmortem control tendons taken of accidentally killed previously healthy persons amianthoid fibres were not found. Ultrastructurally the tendineal amianthoid fibres differ from normal tendon collagen fibrils in many respects. Their diameter (600-1400 nm) is many times larger than that of native collagen fibrils (20-120 nm). The fibre profile is often irregular and the cross-sectioned fibres have a homogeneous granular appearance. In longitudinal sections, the amianthoid fibres are frequently disintegrated and outspread, and some of the fibres have lost their periodicity. In addition, some of the fibres are angulated and show nonparallel organization. Occasionally the amianthoid fibres are calcified.

Adolescent↗
PubMed1993

[Questions concerning two-stage reconstruction of injured flexor tendons. III. Ultrastructure of the tenosynovium in the pseudo-tendon sheath created by using a silicone rod].

Authors have investigated the ultrastructure of the pseudo tendon sheath, formed with silicon rod and man. They have observed a superficial structure, resembling the normal tendon sheath in scanning electron microscopic examination. With transmission electron microscopy phagocyte "A" type and secretion "B" type synovial cells were found. Authors state that the newly formed tenosynovium has an important role in the nutrition of the tendon graft and the prevention of adhesions.

Animals↗
PubMed1993

[Synovitis and bone changes induced by silicone prosthesis].

Authors report on the clinico-pathological analysis of cases of silicon granuloma, developed 5-15 years after the insertion of the prosthesis. It is thought on the basis of histological and electron microscopic examinations that the process of granulation already started, is augmented by the granules, newly arising from the attrition. The silicon granuloma causes not only the damage of the synovia but the destruction of the surrounding soft parts and bones too.

Adult↗
PubMed1992

Vascular changes in the ruptured Achilles tendon and paratenon.

Thirty patients with ruptures of the Achilles tendon were studied. There were 21 men and 9 women with an average age of 36 years. Specimens from the tendon and paratenon in 24 were examined histologically. Tissue samples of 20 were studied by electron microscopy. Marked degenerative, obliterative and/or inflammatory vascular changes were found in all the ruptured tendons and their paratenon. Our findings indicate that poor vascularity play a role in the aetiology of rupture of the Achilles tendon.

Achilles Tendon↗
PubMed1992

Immunohistochemical characterization of pigmented villonodular synovitis.

Pigmented villonodular synovitis is made up of a variety of cells, including round or oval mononuclear cells, fibroblasts, synovial cells and multinucleated giant cells. The mononuclear cells were found to stain positively with anti-lysozyme, anti-alpha-1-antitrypsin, anti-alpha-1-antichymotrypsin and anti-fibronectin. Vimentin was detected in fibroblasts and in lining cells of the synovial membrane as well as in cells of acinus-like structures. The multinuclear giant cells contained lysozyme, alpha-1-antitrypsin and alpha-1-antichymotrypsin but no vimentin.

Adult↗
PubMed1991

Tumors and tumor-like lesions arising in tendons. A clinicopathological study of 75 cases.

Eight cases of malignant tumors, 38 cases of benign tumors, 15 cases of metastatic tumors, and 14 cases of tumor-like lesions arising in tendons seen over a period of 22 years (1967-1988) are surveyed. Benign tumors of tendon occur relatively frequently - in 38 (1.7%) of 2143 tendon biopsies - but malignant tumors (0.37%) and metastases (0.70%) are extremely rare. Malignant tumors occurred most frequently in lower limb tendons, while benign tumors were most often found in the tendons of the hand.

Female↗
PubMed1991

Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients.

We evaluated specimens obtained from the biopsy of spontaneously ruptured tendons in 891 patients who were treated between 1968 and 1989. The specimens, which were removed at the time of repair, included 397 Achilles tendons, 302 biceps brachii tendons, forty extensor pollicis longus tendons, eighty-two quadriceps tendons and patellar ligaments, and seventy other tendons. Age and sex-matched control specimens, from 445 tendons taken at the time of death from the cadavera of previously healthy individuals who died accidentally, also were obtained and evaluated. The histopathological analyses of the specimens included light and polarized light microscopy and scanning and transmission electron microscopy. A healthy structure was not seen in any spontaneously ruptured tendon, but two-thirds of the control tendons were structurally healthy (p less than 0.001). There were characteristic histopathological patterns in the spontaneously ruptured tendons. Most (97 per cent) of the pathological changes were degenerative; they included hypoxic degenerative tendinopathy, mucoid degeneration, tendolipomatosis, and calcifying tendinopathy, either alone or in combination. These changes were also found in 34 per cent of the control tendons, but significantly less frequently (p less than 0.001). In the other twenty-six ruptured tendons (3 per cent), the pathological change was an intratendinous foreign body, rheumatoid tendinitis, a xanthoma, a tumor, or a tumor-like lesion such as an intratendinous ganglion. The findings clearly indicate that, at least in an urban population, degenerative changes are common in the tendons of people who are older than thirty-five years and that these changes are associated with spontaneous rupture.

Achilles Tendon↗
PubMed1991

Structure and macromolecular composition of the myotendineal junction. Histochemical, immunohistochemical and electron microscopic study of the rat calf muscles.

The macromolecular composition and ultrastructure of the myotendineal junction (MTJ) of slow-twitch (type 1) and fast-twitch (type 2) muscle fibers were studied in the gastrocnemius-soleus-Achilles unit of the rat. Both proteoglycans and glycosaminoglycans, type III collagen, fibronectin and laminin could be detected at the MTJ. Due to membrane folding, finger-like processes were seen at the myotendineal junction. The processes of the type 1 fibers are greater in size, however, due to subdivisions, the processes of type 2 muscle fibers had a greater surface than type 1 fibers. The macromolecular composition is similar in both type 1 and type 2 muscle fibers.

Animals↗
PubMed1991

Structure and macromolecular composition of the myotendineal junction. Histochemical, immunohistochemical and electron microscopic study of the rat calf muscles.

The macromolecular composition and ultrastructure of the myotendineal junction (MTJ) of slow-twitch (type 1) and fast-twitch (type 2) muscle fibers were studied in the gastrocnemius-soleus-Achilles unit of the rat. Both proteoglycans and glycosaminoglycans, type III collagen, fibronectin and laminin could be detected at the MTJ. Due to membrane folding, finger-like processes were seen at the myotendineal junction. The processes of the type 1 fibers are greater in size, however, due to subdivisions, the processes of type 2 muscle fibers had a greater surface than type 1 fibers. The macromolecular composition is similar in both type 1 and type 2 muscle fibers.

Animals↗
PubMed1991

Porotic hyperostosis on fossil skulls. A study, using scanning electron microscopy.

Fine structural alterations of cancellous bone in all three forms of porotic hyperostosis (porotic, cribrotic, and trabecular) were examined by the authors. The architecture of cancellous bone was altered, resulting in extended and dilated medullary spaces. Single-bone trabeculae, too, differed from normal by alteration of internal collagen structure and lamellae.

Fossils↗
PubMed1990

[Protothecosis. A new, or rarely recognized disease?].

Two cases of infection caused by Prototheca, belonging to the colourless algae, are discussed. In one of the patients colpitis, in the other one disease of the cubital bursa developed due to Prototheca. In the first case recovery was attained with tetracyclin, in the second case with surgical treatment. Microbiology, epidemiology, pathology and clinical aspects of the insufficiently known in Hungary protothecosis are outlined.

Adult↗
PubMed1990

Pathological alterations in human tendons.

The present authors analyzed the pathological alterations of 1966 tendons examined in the National Institute of Traumatology, Budapest, during the past 18 years. The majority of cases proved to be tendinopathies (hypoxic-degenerative tendinopathy or calcific tendinitis, tendolipomatosis and mucoid degeneration) leading to tendon rupture. The incidence of tendon tumors, foreign bodies, infectious tendon diseases, and other pathological conditions was clearly lower. The methods of tissue preparation and of examination of tendon specimens were also evaluated. Light microscopy was sufficient for the diagnosis of pyogenic tendinitis, tumors, xanthoma, gout, and gangrene. In degenerative tendinopathies and alterations due to hereditary disease, electron microscopy was necessary. Polarization microscopy had a key role in examination of collagen structure and architecture, and identification of foreign bodies in the tendons. Enzyme histochemical and immunohistochemical examination were reliable but not absolutely necessary in the diagnosis of tendon pathology.

Academies and Institutes↗