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Biomedical subjects

L Józsa

Publications and source records attributed to L Józsa.

At least 55 records · Page 3Linked to original sources
PubMed1990

Histochemical profile of muscle spindles of rat's sural muscles.

The histochemical profile of intrafusal fibres of muscle spindles and muscle spindle capsule were analysed in normal sural muscles of a rat. Weak activity of oxidative enzymes (NADH diaphorase, succinic dehydrogenase, lactate dehydrogenase) and creatine phosphokinase were found in bag1 and bag2 fibres, but the oxidative enzyme activity was moderate in chain fibres. High phosphorylase activity was demonstrated in bag fibres as well as in chain fibres. No differences could be detected in adenosine desaminase activity between these various intrafusal fibres. In the outer capsule of muscle spindles, high amount of type III collagen and elastin, but only small amount of type I collagen and fibronectin could be observed.

Adenosine Deaminase↗
PubMed1990

The effect of tenotomy and immobilisation on intramuscular connective tissue. A morphometric and microscopic study in rat calf muscles.

The effect of tenotomy and of immobilisation in lengthened and shortened positions on the intramuscular connective tissue of the calf muscles of the rat was studied morphometrically and with a scanning electron microscope. Both tenotomy and immobilisation produced a marked increase in both the endomysial and the perimysial collagen networks, with a simultaneous decrease in intramuscular capillary density. The increase in connective tissue volume was more pronounced and occurred more rapidly in the soleus, which consists mainly of type I, slow-twitch fibres than in the gastrocnemius, which is mainly of type II, fast-twitch fibres. The relative volume of connective tissue increased in parallel with the duration of immobilisation or after tenotomy. There was slightly more increase after immobilisation in a shortened rather than in a lengthened position.

Animals↗
PubMed1990

[Correlations between the ABO blood group system and tendon rupture].

53 per cent of the 873 cases of subcutaneous (spontaneous) tendon ruptures, treated in the National Institute of Traumatology belonged to the blood group O, and that was significantly higher than in the healthy population (31.1 per cent) of Hungary. The ratio of the tendon rupture patients belonging to the blood group A was significantly lower (27.1 per cent) than in the population (42,4 per cent). The ratio of the cases belonging to the blood group O among the multiple tendon rupture and rerupture patients proved to be over 70 per cent. On the basis of their data authors think that there is a relation between the ABO blood group system and the tendon rupture: those belonging to the blood group O are more endangered by, those belonging to the blood group A are more protected against tendon rupture. No relation was found between the Rh(D) blood group system and the tendon rupture.

ABO Blood-Group System↗
PubMed1990

[Lesions of the extensor muscles of the knee caused by meniscus injury].

The damage of the knee extensors was examined with integrated EMG and with histochemical and electron microscopical methods in 23 patients with meniscal injury. The integrated DMG has proved in 2/3 of the patients tonic, in 1/3 both tonic and phasic damage of the muscle function. With histochemical examination the decrease of the ratio of the fibers of type 1 was found and also the atrophy of the same fibre type cells in 18-36 per cent. Ultrastructural examinations have shown out of the damage of the contractive elements an increase of the interstitial connective tissue together with alterations of the arterioles in the knee extensors following meniscal injuries.

Humans↗
PubMed1990

[Recurrent infantile digital fibromatosis].

In connection with a boy's case, receiving treatment in their institute several times, authors sum up our knowledge on infantile relapsing digital fibromatosis, first time in Hungary. Results of histological and electronmicroscopic examination are reported compared to results of foreign authors' studies of similar subject.

Amputation, Surgical↗
PubMed1989

Alterations in dry mass content of collagen fibers in degenerative tendinopathy and tendon-rupture.

The dry mass concentration and collagen fiber morphology of intact, as well as of degenerated and ruptured human Achilles, biceps brachii, extensor pollicis longus and quadriceps tendons, were determined by using the interference microscopical technique. The variation in the collagen fiber thickness was demonstrated in different intact tendons, the fibers being largest in the Achilles and smallest in the extensor pollicis longus tendons. However, the intact tendons exhibited only thick collagen fibers. In the degenerative tendinopathies an increase of the dry mass content was observed, being especially marked in calcifying tendinopathy. In the degenerated tendons the average collagen fiber diameter had decreased, and two clearly distinct populations of thick and thin fibers were observed. The dry mass content of the thick fibers was significantly greater than that of the thin fibers. The present results demonstrate striking changes in the collagen and its dry mass content in degenerative tendinopathy, thus also increasing the susceptibility to ruptures.

Collagen↗
PubMed1989

[Immunohistochemical and immunologic changes in aponeurosis in Dupuytren's disease].

Authors examined the aponeurosis of 23 patients with Dupuytren's contracture and of 5, formerly healthy persons, who died in consequence of accidents. It was found that the IgA and IgM content of the palmar aponeurosis is significantly elevated in Dupuytren's disease. The distribution of the immunglobulin containing cells and the fibronection localisation of the aponeurosis was also examined. On the basis of their examinations they think that the autoimmun mechanism may have a role in the development of Dupuytren's disease.

Dupuytren Contracture↗
PubMed1989

Quantitative alterations of intramuscular connective tissue in calf muscles of the rat during combined hypoxia and hypokinesia.

The investigations were designed to study the long-term effect of hypoxia, hypokinesia and of combined hypokinesia and hypoxia on the skeletal muscle in the rat. In the muscles of the hypoxic and hypokinetic animals serious degenerative changes were found and the fibre-type ratio was altered. In the hypoxic animals moderate fibrosis was revealed. In the hypokinetic, and hypokinetic + hypoxic animals the amount of connective tissue was 5 to 10-fold greater in the calf muscles as compared to the control.

Adenosine Triphosphatases↗
PubMed1989

Glycogen-enzymes containing bodies in type 2 fibres of tenotomized muscles in the rat.

Inclusion bodies containing glycogen-enzymes were found in 30 to 60% of type 2 fibres of tenotomized calf muscles (m. gastrocnemius, m. soleus, m. plantaris) in rats, using histochemical reactions. The bodies appeared within 1 week after the tenotomy and were localized both in the central and the subsarcolemmal regions and rarely extruded into the extracellular space. These aggregates are 3 to 15 microns in length and 2 to 11 microns in diameter. In addition to glycogen, these bodies also contained various enzymes of the glycogen metabolism such as phosphorylase, a branching enzyme, and glucose-6-phosphatase, but showed no NADH-reductase, lactate dehydrogenase, or myofibrillar ATP-ase activity. The results indicate that glycogen-enzymes containing bodies are a degenerative phenomenon, which occurs only in type 2 fibres of the tenotomized muscles.

1,4-alpha-Glucan Branching Enzyme↗
PubMed1989

[Problems of the two-stage restoration of flexor tendon injuries. II. Light- and scanning electron microscopy studies of flexor tendon sheaths from hens and from humans].

Authors examined the normal flexor tendon/tendon sheat unit of the toes of the hen and in the zone Verdan 2 of the human hand with light and scanning electron microscope. The fine structure of the synovial membrane was studied with special care. It was found, in accordance with some previous literary data, that the morphology of the hen's and human tenosynovium resemble to each other. The structures of the parietal visceral synovial membranes are described and compared, and the mechanism of the secretion of the synovial fluid is discussed. The results of the present investigations may serve, over the description of the normal anatomical relations, as a comparison to other experiments of two-phase tendon transplantations with the formation of pseudo tendon sheats and also for clinical practice.

Animals↗
PubMed1989

[Changes in the tension receptors of skeletal muscles after tenotomy and immobilization].

Morphometric and histochemical changes of muscle spindles and tendon spindles of Golgi were studied in the soleus and gastrocnemius muscles of tenotomized and immobilized rats. The number of intrafusal fibres and mechanoreceptors did not change after either tenotomy or immobilization. The diameter of intrafusal fibres decreased by 14 to 40% three weeks after tenotomy or immobilization. The histochemical characteristics of muscle fibres were also changed. The capsule of mechanoreceptors was found thickened, the intracapsular space disappeared. The capsule was tensely attached to the mechanoreceptors.

Animals↗
PubMed1988

Cortical and trabecular osteopenia after immobilization. A quantitative histological study of the rat knee.

The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the knee was fixed in extension and in 18 in flexion. The time of immobilization was for 1, 2 and 3 weeks, with 12 animals in each group and 6 knees in extension and 6 in flexion. The following parameters were measured: (1) the mean thickness of subchondral and both periosteal cortices; (2) cortical porosity; (3) trabecular bone volume; (4) relative osteoid volume, and (5) relative osteoid surface. The mean cortical thickness decreased during the period of immobilization and the cortical porosity significantly increased. The trabecular bone volume was unaltered in the first week, but after 3 weeks it had decreased. The relative osteoid volume decreased significantly during the three weeks, and the relative osteoid surface moderately increased. No relationship was found between the quantitative osteopenic alteration of subchondral bone and the position of immobilization.

Animals↗
PubMed1988

The effect of tenotomy and immobilization on muscle spindles and tendon organs of the rat calf muscles. A histochemical and morphometrical study.

The morphological and histochemical alterations in the muscle spindles and Golgi tendon organs of tenotomized or immobilized calf muscles of rats (m. soleus, m. gastrocnemius) were studied in 54 animals. The intact contralateral feet served as controls. There was no change in the number of mechanoreceptors in either the tenotomized or the immobilized muscles. The diameter of the intrafusal fibers was increased somewhat after 1 week, but decreased by 14% to 40% in 3 weeks. The periaxial space of muscle spindle had diminished or disappeared by 2 weeks from the beginning of the procedures. The thickness of the outer capsule of the spindles had markedly increased, especially in the polar region. In the Golgi tendon organs the capsule had also thickened significantly and the internal space diminished. The alterations were similar following tenotomy or immobilization, but more marked after tenotomy than after immobilization.

Animals↗