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Biomedical subjects

L Jordan

Publications and source records attributed to L Jordan.

At least 19 recordsLinked to original sources
PubMed1992

Identification and characterization of a novel Bacillus thuringiensis delta-endotoxin entomocidal to coleopteran and lepidopteran larvae.

A new class of Bacillus thuringiensis delta-endotoxins, or insecticidal control proteins (ICPs), is defined by an apparently cryptic protein with a unique primary structure and novel entomocidal specificity for certain coleopteran and lepidopteran species. The discovery of a new group of ICPs will extend the use of this natural insecticide in integrated pest-management systems.

Amino Acid Sequence↗
PubMed1991

Palliative care in a general teaching hospital. 2. Establishment of a service.

OBJECTIVE: To assess the first year of operation of a palliative care service in a general teaching hospital. DESIGN, SETTING, PATIENTS: A retrospective analysis of 241 terminally ill patients referred to the Austin Hospital Palliative Care Service during its first year of operation. MAIN OUTCOME MEASURES: The occurrence and relief of pain, the occurrence and management of social and psychological problems, involvement of allied health services and the place of death. MAIN RESULTS: Unrelieved pain was the most frequent medical problem but, with appropriate medical management as well as input from other members of the multidisciplinary team, all patients achieved satisfactory pain control. The occurrence and severity of social and psychological problems was greater than expected. Most of the patients were discharged home and referred to domiciliary palliative care services; one-quarter of patients were able to die at home, one-third died in an inpatient hospice, and the remainder died in hospital. CONCLUSIONS: The Service was able to achieve most of its stated aims and has generated a much improved appreciation of the palliative care needs of patients with terminal illness and their families within the Hospital. A multidisciplinary approach to the management of terminally ill patients is crucial, and this Service has been successful despite limited staffing because of the willing involvement of other Units and Services in the Hospital. The difficulties inherent in the evaluation of a palliative care program (quality of life, cost-effectiveness) are discussed.

Hospital Departments↗
PubMed1991

Caregiver's anticipatory grief in dementia: a pilot study.

Twenty-seven wives who care for their spouses suffering from dementia completed the Anticipatory Grief Scale (AGS) and the Hopkins Symptom Checklist--SCL-90-R. The alpha coefficient for the AGS was 0.84, indicating good internal consistency. The AGS was also positively and significantly correlated (p less than 0.001) with the depression, anxiety, and hostility dimensions of the SCL-90-R, demonstrating good validity. The study explores bereavement issues of spouses of patients with dementia and provides preliminary findings on a new instrument to measure anticipatory grief.

Aged↗
PubMed1991

A profile of aphasia services in three health districts.

The study examines language rehabilitation provisions for aphasic people and their families in three health districts, as perceived by speech and language therapists. The study is exploratory. Semi-structured interviews were carried out with each District Speech Therapist and with speech and language therapists whose caseloads regularly included aphasic people, and documentary evidence was used where available. Comparison is made of: speech and language therapy expenditure and staffing in the three districts (West Suffolk, West Essex and Newcastle-upon-Tyne); aphasia therapy staffing; caseloads of aphasic people; patterns of treatment (inpatient/outpatient/community; individual/group) and reasons for these; provision for relatives; relationships between speech and language therapy and other services; volunteer involvement; and speech and language therapists' work situations (support from colleagues, post-qualification training, secretarial support and accommodation). Differences are found in levels of provision, with Newcastle having considerably more resources devoted to aphasia services than the other two districts, and modes of service delivery. Some shared concerns are identified (e.g. relationships with other professions, accommodation and transport). Implications of the findings are discussed and areas for further research identified.

Adolescent↗
PubMed1991

Periprosthetic knee sepsis. The role of irrigation and debridement.

Thirty-three infected total knee arthroplasties were treated by irrigation, debridement, and intravenous antibiotics. These cases were retrospectively reviewed with an average follow-up period of 4.5 years. There were 12 revisions and 21 primary arthroplasties in the series. Thirty-two knees were openly irrigated and debrided, and one was arthroscopically treated. In 20 of 33 knees, infection recurred--a reinfection rate of 61%. The authors attempted to identify factors influencing success and failure of infection eradication. There was a statistically significant improvement in the success rate of knees irrigated and debrided within four weeks of index surgery (p less than .05). No statistically significant correlation was found between success and failure with regard to gender, age, preoperative diagnosis, previous surgery, length of intravenous antibiotics, or time from clinical symptoms to debridement. The authors believe that irrigation and debridement have a role in the immediate postoperative period. Caution should be used in periprosthetic knee infection appearing greater than four weeks from index surgery.

Adult↗
PubMed1990

Activity of interneurons within the L4 spinal segment of the cat during brainstem-evoked fictive locomotion.

Extracellular recordings from interneurons located in the L4 spinal segment were made during fictive locomotion produced by electrical stimulation of the mesencephalic locomotor region (MLR) in the paralysed decerebrate cat. Only interneurons within the L4 segment which received group II input from quadriceps, sartorius or the pretibial flexor muscle afferents and which had axonal projections to motor nuclei in L7 were selected for analysis. During the fictive step cycle two thirds of these interneurons fired action potentials during the time of activity in the ipsilateral hindlimb flexor neurograms. These cells were also less responsive to peripheral input during the extension phase of the fictive locomotion cycle. The remaining one third of the interneurons examined were not rhythmically active during locomotion. The possible contributions of the midlumbar interneurons to motoneuron activity during locomotion are discussed.

Action Potentials↗
PubMed1990

The relationship between changing answers and performance on multiple-choice nursing examinations.

The purpose of this study was to investigate answer changing among undergraduate nursing students on multiple choice examinations. The sample included 284 students enrolled in the upper division of a baccalaureate nursing program. Answer sheets were examined for erasures to determine the number and direction of changes made. The results of the study indicated that most students changed at least one answer. Analysis of the data indicated that there was a significant difference between changing from wrong to right versus changing from right to wrong. About 55.3% gained points as a result of changing answers while only 18.3% lost points.

Adult↗
PubMed1978

Basic world views.

Explore the source record for details and available documents.

Christianity↗
PubMed1977

Complementation of adeno-associated satellite virus (AAV) by temperature-sensitive mutants of adenovirus type 31.

Temperature-sensitive (ts) matants of human adenovirus type 31 were able to complement adeno-associated satellite virus (AAV) antigen production in both HEK and KB cells at both permissive and non-permissive temperatures. However, mutant ts 94, an adenovirus 31 mutant which produces apparently normal amounts of structural protein and DNA but is defective in maturation, was significantly inhibited in its ability to potentiate AAV infectivity at the non-permissive temperature. Normal AAV DNA and adenovirus DNA were isolated from co-infections with AAV and mutant ts 94 at the non-permissive temperature. We suggest that an adenovirus-coded maturation function common to both adenovirus and AAV maturation is defective in the ts 94 system.

Adenoviruses, Human↗