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Biomedical subjects

L Judkiewicz

Publications and source records attributed to L Judkiewicz.

At least 19 recordsLinked to original sources
PubMed1991

Consequences of the presence of elongated variant of the major transmembrane protein (Band 3 protein) in the human erythrocyte.

Among 56 persons studied, 6 were heterozygous with respect to the elongated variant of the Band 3 protein (anion transporting protein) of the erythrocyte membranes. Erythrocytes containing the variant Band 3 protein did not exhibit morphologic abnormalities, alterations in electron spin resonance spectra of maleimide-spin labeled membranes. In the rate of membrane 'self-digestion' or in chloride permeability. They did however show an increased membrane binding of hemoglobin and aldolase.

Anion Exchange Protein 1, Erythrocyte↗
PubMed1988

The effect of donor age on the packing susceptibility of erythrocytes.

The study of 411 healthy persons indicates that erythrocyte susceptibility to centrifugal packing at 200 g increases with age, evidencing an age-related decrease in red cell deformability. Positive correlations between donor age and blood plasma fibrinogen concentration and erythrocyte sedimentation rate were confirmed. The impairment of red cell deformability may affect the circulatory efficiency in the aged.

Adolescent↗
PubMed1987

A spin-label study of membrane proteins and internal microviscosity of erythrocytes in hereditary spherocytosis.

Electron spin resonance (ESR) spectra of erythrocyte membranes of patients with hereditary spherocytosis (HS) and of healthy controls labeled with a maleimide spin label did not differ significantly both before and after prolonged incubation at 37 degrees C. It suggests that the different behavior of spin-labeled HS erythrocyte membranes upon incubation at a higher temperature reported previously is due indeed to structural abnormalities of HS red cell membranes and not to alterations in their proteolytic activity. Measurements of the rotational correlation time of Tempamine spin probe demonstrated a significant elevation of internal microviscosity of erythrocytes in HS, more pronounced in non-splenectomized patients.

Adolescent↗
PubMed1987

Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis.

The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin: Band 3 ratio reported for erythrocyte membranes in HS.

Blood Proteins↗