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Biomedical subjects

L Kammerer

Publications and source records attributed to L Kammerer.

At least 37 records · Page 2Linked to original sources
PubMed1988

Sex- and age-dependence of platelet aggregation in diabetes mellitus.

Platelet aggregate ratios (PAR) were determined, and threshold concentrations (ED50) of epinephrine, adenosine diphosphate (ADP), and collagen were estimated by platelet aggregometry in 88 IDDM and 52 NIDDM patients without hyperlipidaemia or azotaemia, and in 106 healthy volunteers to revise the question of hyperaggregability in diabetes. ED50-s showed a tendency for negative correlation with age, significant in female but not in male controls. Similar trends were obtained in IDDM and NIDDM females, but were not in IDDM and NIDDM males. The ED50-s of different aggregating agents positively correlated with each other. ED50-s were higher in men than in women in both controls and IDDM patients. Similar but minor differences were observed between women and men in NIDDM. IDDM patients had significantly lower PAR and collagen ED50, and a tendency for epinephrine and ADP to be lower as compared to the sex- and age-matched controls. The differences of PAR were the same, while those of ED50-s were diminished in older NIDDM patients compared to the matched controls. It is concluded, that the previously observed general hyperaggregability in diabetic patients may have partly resulted from sex- and age differences. Threshold concentrations should be compared to sex- and age-matched controls.

Adolescent↗
PubMed1986

Circulating blood volumes in diabetic patients.

To examine the mechanism of cardiac dysfunction in diabetes, total circulating blood volume, cardiac and stroke volumes were measured by radioisotope method in 44 patients with type 1 and type 2 diabetes. Considerable difference in actually circulating blood volume could be demonstrated in diabetic patients, which seemed to be dependent on the control of the carbohydrate metabolism. The achievement of well controlled carbohydrate metabolism in diabetics has a great importance with special respect also to the blood volumes.

Adult↗
PubMed1984

Alterations of the serum cortisol and blood glucose in brain-injured patients.

Serial serum cortisol and blood glucose measurements in brain- injuried patients showed consistently higher levels in comatose patients than in patients with other injuries not involving the brain or brain stem. In the brain-injured patients the cortisol and glucose levels were related to the degree of injury, with higher and more widely scattered values found with deeper levels of unconsciousness. The cortisol and glucose levels showed 4 distinct patterns of response, depending upon the level of coma. The observed hyperglycaemia was directly related to cortisol levels up to 12 mmol/l glucose whereas higher blood glucose levels appeared to be related to the concentrations of other hormones, e.g. glucagon, growth hormone and the catecholamines. In brain-injured patients persistently high levels of glucose and cortisol in blood portend a fatal outcome.

Blood Glucose↗
PubMed1984

Myocardial systolic alterations of insulin-dependent diabetics in rest.

Left ventricular systolic function was tested in 27 insulin-dependent diabetic patients by measuring the systolic time intervals. In diabetics longer pre-ejection period, and higher PEP/LVET quotient were found showing a good correlation with the values of glycosylated haemoglobin. These findings emphasize the importance of metabolic control in the development of cardiac dysfunction.

Adolescent↗
PubMed1984

Different types of proteinuria in diabetes mellitus.

Urinary protein concentration and urinary protein pattern as determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis, were investigated in 53 type 1 diabetic children and in 56 (41 type 1 and 15 type 2) diabetic adults. Reversible tubular proteinuria was found in 26 diabetic children with hyperglycaemic ketoacidosis. Among the patients, 43 exhibited physiological, 31 fixed tubular and nine glomerular type proteinuria. The prevalence of retinopathy and neuropathy in the different patient groups has also been evaluated. Urinary protein concentration appeared to be above the usual reference values during hyperglycaemic ketoacidosis, and was normalized with the successful control of metabolism. In the other three groups, urinary protein concentration was increased only in the case of glomerular type proteinuria. It is suggested that the above classification characterizes the development of diabetic nephropathy, progressing from reversible tubulointerstitial dysfunction through fixed tubulointerstitial dysfunction to glomerulopathy.

Adolescent↗
PubMed1982

[Studies of glycosylated hemoglobins and albumins in diabetes mellitus with retinopathy].

The correlation between the diabetic retinopathy and the levels of glycosylated haemoglobin and albumin was examined in 133 diabetic patients. 25 healthy persons served as controls. 53 out of the 133 diabetic patients suffered in different grades of diabetic retinopathy, 80 diabetics developed no retinopathy. There was no significant difference in the age of patients with or without retinopathy. The duration of diabetes was significantly longer in diabetics with retinopathy. The glycosylated haemoglobin and albumin levels of diabetics were significantly higher as compared to the levels of the controls. There was no difference in the glycosylated haemoglobin and albumin levels of diabetic patients with or without retinopathy. According to these results there is no correlation between the formation of diabetic retinopathy and the elevated levels of glycosylated haemoglobin and albumin. Thus the development of diabetic retinopathy takes many years, the cause of our results may be the relative short period of the examinations. Following this study we do hope to get more data to this important question.

Adult↗
PubMed1982

Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus.

In diabetic patients with poor metabolic control (Group I) and with repeated hypoglycaemic crises (Group II) the serum concentration of cholesterol, triglyceride, of LDL, VLDL and HDL-cholesterol, as well of VLDL and LDL + HDL-triglyceride were measured before and after metabolic control and before and after control of the hypoglycaemic crises. Parallel with the control of diabetic metabolism in Group I, achieved in 15 +/- 6 days, a significant increase in HDL-cholesterol concentration was demonstrable, together with a decrease in the mean value of blood glucose and of daily urinary glucose excretion. In the diabetic patients of Group I, the LDL-cholesterol, serum triglyceride and VLDL-triglyceride levels were significantly higher, the HDL cholesterol levels significantly lower before as well as after metabolic correction, than in the control group. In Group II the serum lipid and lipoprotein lipid concentrations remained unaffected by the control of the hypoglycaemic crises. The results indicate that lipid metabolism in diabetes may considerably be affected by insulin deficiency, but it will respond to an intensified insulin effect. An increase in the concentration of the antiatherogenic HDL-cholesterol is an essential factor of the improvement.

Adult↗
PubMed1981

[Changes in the serum cortisol and blood glucose level in cerebral injuries (author's transl)].

In our serial examinations we found, that that the starving blood glucose and cortisol levels showed a more pronounced increase in brain injuries with coma than in other serious injuries with different localisation and without loss of consciousness. Also a correlation was found between the changes of the cortisol and glucose levels and the state of consciousness: the deeper was the coma, the more elevated were these levels, with a greater divergence of the values. Four types were observed in the changes of these two values, according to the outcome of the injury, but in the first 2 weeks the mean values of these parameters always displayed a gradual evelation, according to the gravity of the disturbances of consciousness. From the endocrine point of view, the elevation of the blood glucose up to 200 mg% is caused by hypercortisolemia, while above 200 mg% other hormonal changes have to be assumed. Both in the changes of the blood glucose, and of the cortisol level certain statistically significant signs were found, which predicted the fatal outcome.

Blood Glucose↗
PubMed1979

Alterations of the basal serum insulin and blood glucose in brain-injured patients.

Serial fasting blood glucose and basal serum insulin were measured in brain-injured patients. The endocrine changes were compared with the level of consciousness. Evaluating the serial examinations of 92 brain-injured and 31 control patients we came to the following conclusions. There is a quantitative correlation between the alterations in the level of consciousness and the fasting blood-glucose and serum-insulin levels in brain-injured patients. Deep coma is connected with a high blood-sugar level, clear consciousness with a normal glucose level. The insulin level is, however, decreased in the comatose state and normal in the state of clear consciousness. According to the alterations in blood-glucose and insulin levels, brain-injured patients can be divided into four groups. The alterations in the insulin level cannot give a proper explanation of the blood-sugar changes. Some changes in the levels of both blood glucose and serum insulin may have prognostic significance. According to our results it can be supposed that certain cerebral structures take part in the regulation of the basal insulin secretion.

Blood Glucose↗