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Biomedical subjects

L Kun

Publications and source records attributed to L Kun.

67 records · Page 4Linked to original sources
PubMed1976

[Biophsical study of dental tissues under the effect of a local strontium application].

Microradiographic and electronmicroscopic observations show that topical application of concentrated strontium chloride solution on an abraded dentinal surface caused the formation in the dentine of very compact superficial layer composed of fine granules and with a high degree of radiodensity. This layer not only forms a continuous deposit on the superficial zone, but also penetrates and fills the canclicules to a certain distance. A barrier is thus created, diminishing the permeability of the dentine, which would explain the desensitization of the tooth. Electron probe microanalysis and X-ray diffraction studies show that the fundamental mechanism of the formation of strontium deposits is an exchange with the calcium fo the dentinal tissue, and recrystallization in the form of strontium apatite.

Dental Enamel↗
PubMed1976

[Examination of the breast with ultrasound: limits and possibilities (authro's transl)].

Following a brief introduction to ultrasound the advantages and disadvantages of this examination are presented with regard to differentiation of benign and malignant tumors of the breast. This method is unsuitable for screening because of its present technical failures: its only importance lies in the differential diagnosis of benign lesions. These statements are based upon the case material of the Department of Gynecology and Radiology of the Postgraduate Medical School of Budapest.

Adenofibroma↗
PubMed1975

[Ultrasonic studies in gonadal dysgenesis].

Authors studied the internal genital organs of patients with gonadal-dysgenesis by ultrasonography. Streak gonads confirmed by laparotomy and histology have characteristic signs with ultrasonogram as follows: In the middle of the screen, or a little laterally, deeper than the normal uterus used to be, there is a small echo-free territory, which indicates the rudimentary uterus. On both sides in some cases Fallopian tubes were detectable. They give a centrally pointed echo-free pattern with a few mm in diameter, and a tube-like shape. On the place where one usually finds the echo-free outline of the normal ovaries, a zone of multiple echo's is visible. On base of their experiences, authors regard ultrasonic technique as a useful additional diagnostic procedure in cases of gonadal-dysgenesis.

Fallopian Tubes↗
PubMed1975

[Experience with cephalometry in the determination of labor in diabetic pregnant women].

Foetal biparietal diameter was measured with ultrasound techniques in 35 diabetic pregnant mothers. 203 measurements were compared to 589 dates values which were obtained in 100 normal pregnant women. There were no differences in the mean values of biparietal diameter and the weekly growth rates in comparison to non diabetic values. It was concluded at thin diabetic pregnancies in spite of the frequent occurrence of the macrosomie, the ultrasonic diagnostic approach is a suitable method for estimating of the foetal maturity.

Cephalometry↗
PubMedDate not supplied

Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study.

PURPOSE: To assess the efficacy and define the toxicity of paclitaxel given at a dosage of 350 mg/m2 every 3 weeks as a 24-hour continuous infusion to children with recurrent or progressive primary brain tumors. PATIENTS AND METHODS: Seventy-three eligible patients, ages 4 months to 19 years, with progressive or recurrent primary brain tumors were treated according to a Pediatric Oncology Group (POG) phase II protocol with paclitaxel (POG 9330). Tumor histologic strata included: astrocytoma (n = 4), malignant glioma (n = 13), medulloblastoma (n = 16), brain stem glioma (n = 15), ependymoma (n = 13), and miscellaneous histologies (n = 12). All patients had previous histologic confirmation of a primary intracranial or spinal cord tumor with magnetic resonance imaging or computed tomography documentation of unequivocally measurable progressive or recurrent disease. All patients had received previous therapy including surgery, radiation therapy, and/or chemotherapy, but no patient had been previously treated on more than one phase II trial. Paclitaxel was administered as a 24-hour intravenous infusion at a dosage of 350 mg/m2 every 3 weeks. Neurologic and neuroradiologic reevaluations were performed after every second course. Patients were allowed to continue therapy for a total of 18 cycles in the absence of progressive disease or unacceptable toxicity. RESULTS: Seventy-five patients were enrolled onto the POG 9330 protocol; two ineligible patients were removed from the study before receiving any therapy. Of the 73 eligible patients, 72 were evaluable for toxicity and 70 were either fully or partially evaluable for disease response. There was one complete response and three partial responses (5.7%). Twenty patients had stable disease for more than 2 months. Toxicities included mild nausea, central nervous system toxicity, myelosuppression, and febrile neutropenia, including one septic death. One grade 2 and two grade 3 allergic reactions occurred. No cardiac toxicities or arthralgias were reported. CONCLUSION: Paclitaxel is well tolerated in children with recurrent or progressive brain tumors at this dosage and schedule and may result in short-term disease stabilization in this patient population. The lack of a significant number of patients with measurable disease regression, however, precludes it from being identified as an active agent when administered as a single agent by 24-hour continuous infusion.

Adolescent↗