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Biomedical subjects

L L Southern

Publications and source records attributed to L L Southern.

At least 91 records · Page 5Linked to original sources
PubMed1993

Effect of chromium picolinate on growth and serum and carcass traits of growing-finishing pigs.

Three experiments were conducted to evaluate chromium picolinate (CrPic) in growing-finishing pigs. Treatments were replicated four times within each experiment with three pigs per replicate in Exp. 1 and four pigs per replicate in Exp. 2 and 3. Average initial weights were 37.8, 30.5, and 22.4 kg in Exp. 1, 2, and 3, respectively. In Exp. 1, the basal corn-soybean meal diet (B, 120% NRC Lys) was supplemented with 0, 25, 50, 100, or 200 ppb of Cr from CrPic. Daily gain was increased (Cr cubic, P < .02) and serum cholesterol decreased (Cr cubic, P < .08) by addition of CrPic. In Exp. 2, the basal diet was supplemented with 0, 100, 200, 400, or 800 ppb of Cr from CrPic. Daily gain and ADFI were decreased (Cr linear, P < .05) by CrPic. Serum cholesterol also was decreased (Cr quadratic, P < .05) by CrPic. Longissimus muscle area (LMA) and percentage of muscling (MUS) were increased (Cr quadratic, P < .01) and 10th rib fat (TRF) was decreased (Cr quadratic, P < .01) by CrPic. In Exp. 3, pigs were allotted to the following treatments: 1) B, 2) B + 1,467 ppb of picolinate (Pic), 3) B + 200 ppb of Cr from CrCl3.6H2O, 4) B + 1,467 ppb of Pic + 200 ppb of Cr from CrCl3.6H2O, 5) B + 100 ppb of Cr from CrPic, or 6) B + 200 ppb of Cr from CrPic. Longissimus muscle area and MUS were increased (P < .01) and TRF decreased (P < .01) in pigs fed CrPic but not in pigs fed CrCl3.6H2O and(or) Pic.(ABSTRACT TRUNCATED AT 250 WORDS)

Adipose Tissue↗
PubMed1993

Ruminal distribution of zinc in steers fed a polysaccharide-zinc complex or zinc oxide.

Six Holstein steers (initial BW 335 kg) were used in a replicated 3 x 3 Latin square design to study the distribution of Zn in ruminal contents from a conventional Zn source (ZnO) or Zn sequestered to a polysaccharide (PC-Zn). Treatments consisted of a basal diet (no Zn supplementation) and the basal diet supplemented with Zn from either PC-Zn or ZnO. Steers were provided with 208, 920, or 896 mg of Zn/d from basal, PC-Zn, or ZnO, respectively. On collection day, steers were dosed with 800 mg of Zn from each Zn supplement and whole ruminal contents (WRC) were sampled at 1, 2, 4, 6, and 8 h postdosing. The cell-free (soluble) Zn concentrations in steers fed the PC-Zn or ZnO supplements decreased (P < .05) rapidly after dosing. Mean Zn concentrations of the cell-free fraction were considerably lower than either microbial or particle fractions of WRC. Compared with ZnO, the PC-Zn source resulted in higher (P < .05) cell-free Zn at 1 and 2 h after dosing and higher (P < .05) Zn concentrations (micrograms/gram of DM) in the fluid- and particle-associated microbial and particle fractions. Compared with basal, fluid-associated microbial DM concentration tended to be higher (P < .10) at 6 and 8 h with PC-Zn and ZnO. Results indicate a rapid disappearance of Zn from the soluble fraction and a high concentration of Zn in the DM of the microbial and particle fractions of WRC. Furthermore, PC-Zn resulted in higher levels of Zn in all fractions of WRC, and Zn supplementation tended to increase microbial DM production at later sampling times.

Administration, Oral↗
PubMed1993

Effect of dietary sodium zeolite A on zinc utilization by chicks.

Two experiments were conducted with chicks from 5 to 15 days posthatching to study the effect of sodium zeolite A (SZA) on Zn utilization. The corn-soybean meal basal diet was supplemented with ZnCO3 to provide three levels of dietary Zn (35, 40, and 85 ppm) in Experiment 1, and two levels of dietary Zn (85 and 4,000 ppm) in Experiment 2. Experimental diets also contained either 0 or .75% SZA, resulting in a 3 x 2 and a 2 x 2 factorial arrangement of treatments in Experiments 1 and 2, respectively. The tendency for increased growth, feed intake, and hematocrit in chicks fed Zn-supplemented diets in Experiment 1 suggests that the 35-ppm level of Zn in the basal diet was marginal for chicks. Both supplemental Zn and SZA increased (P < .02) hematocrit and plasma, pancreas, and tibia Zn and decreased (P < .02) tibia Cu. Sodium zeolite A increased (SZA by Zn, P < .03) tibia Al and tended to increase (SZA by Zn, P < .09) liver Fe in chicks fed either 35 or 85 ppm Zn, but SZA had no effect on tibia Al and liver Fe in chicks fed 40 ppm Zn. In Experiment 2, both SZA and excess dietary Zn decreased gain, feed intake, gain: feed, hematocrit, hemoglobin, and plasma alkaline phosphatase (AP) activity, and increased tibia, liver, and pancreas Zn, and tibia Al. In addition, excess Zn increased (P < .05) plasma Zn and liver Al but decreased (P < .01) plasma, liver, and pancreas Cu and percentage of tibia ash. The addition of SZA enhanced the adverse effects of excess Zn by further decreasing feed intake, hematocrit, hemoglobin, and plasma AP and Cu and by increasing tibia Al and liver Zn. Sodium zeolite A increased pancreas (P < .09) and tibia (P < .03) Zn regardless of dietary Zn concentration; however, SZA increased plasma Zn only in chicks fed 85 ppm Zn (SZA by Zn, P < .03). Sodium zeolite A tended to improve Zn utilization in chicks fed inadequate Zn but exacerbated the adverse effects of feeding excess Zn. The addition of SZA to the diet of chicks fed inadequate, adequate, or toxic levels of Zn resulted in increased tissue Zn concentration.

Alkaline Phosphatase↗
PubMed1993

Research note: interactive effects of sodium zeolite A and Eimeria acervulina infection on growth and tissue minerals in chicks.

Two experiments were conducted to assess the interactive effects of dietary sodium zeolite A (SZA) and experimental Eimeria acervulina infection on growth and tissue mineral concentrations in chicks. The average initial weight of the chicks was 71.8 g, and the experimental periods were from 5 to 15 days posthatching. In both experiments, the corn-soybean meal basal diet was supplemented with 0 or .75% SZA and fed to uninfected chicks or to chicks infected with 4 x 10(5) sporulated E. acervulina oocysts on Days 0, 3, and 6 of the experiments. Both coccidial infection and SZA reduced (P < .05) gain and feed intake; however, feed efficiency was reduced (P < .01) only in the coccidiosis-infected chicks. Neither SZA nor the coccidial infection affected (P > .10) plasma Ca or P, tibia P, liver Ca, Zn, Fe, or Mn, or pancreas Cu. Sodium zeolite A increased (P < .05) plasma Zn but only in uninfected chicks (SZA by coccidiosis, P < .10). The coccidial infection decreased (P < .02) tibia ash percentage. Sodium zeolite A decreased tibia Ca in uninfected chicks but increased tibia Ca in coccidiosis-infected chicks (SZA by coccidiosis, P < .10). The coccidial infection increased (P < .05) tibia Mg, Cu, Fe, Pb, Mn, and Al concentrations. Dietary SZA also increased (P < .02) tibia Zn, Mn, and Al concentrations. The coccidial infection decreased (P < .02) tibia Zn concentration, and SZA decreased (P < .05) tibia Mg and Fe. Sodium zeolite A by coccidiosis interactions (P < .10) were evident in tibia Zn, Fe, Mn, and Al concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

Effect of dietary sodium bicarbonate on growth, liver copper concentration and incidence of gastric ulceration in pigs fed excess dietary copper.

An experiment was conducted with growing-finishing pigs to evaluate the interactive effects of dietary sodium bicarbonate (1%) and excess dietary Cu (250 mg/kg diet) on growth, liver Cu accumulation and incidence of gastric ulceration. A 2 x 2 factorial arrangement of treatments was used and each treatment was replicated four (Trial 1) or three (Trial 2) times with four pigs per replicate. Initial weight of the pigs was 57 (Trial 1) and 32 kg (Trial 2). Growth rate and efficiency of feed utilization were not affected (P > .10) by treatment. Sodium bicarbonate increased (P < .06) the incidence of gastric ulceration and decreased (P < .01) dressing percentage. Dietary Cu (P < .01) increased liver Cu concentration but did not affect (P > .10) the incidence of gastric ulceration.

Animal Feed↗
PubMed1992

Effect of dietary sodium zeolite A and graded levels of calcium and phosphorus on growth, plasma, and tibia characteristics of chicks.

Sodium zeolite A (SZA), a synthetic sodium aluminosilicate having a high ion exchange capacity, has been shown to influence Ca and P utilization in chickens. A 3 x 2 x 2 factorial arrangement of treatments was used to investigate the effect of dietary P (.41, .55, and .69% total P), Ca (.6 and 1%), and SZA (0 and .75%) on growth, plasma, and tibia characteristics of chicks from 5 to 15 days of age. Growth, feed intake, gain:feed ratio, and tibia characteristics were influenced by dietary Ca and P in a manner consistent with dietary recommendations for these macro minerals. The addition of Ca, SZA, or both exacerbated the adverse effects of feeding low-P diets, yet alleviated the adverse effects of feeding a low-Ca, high-P diet. Dietary SZA had no effect (P greater than .5) on plasma Ca or alkaline phosphatase; however, SZA reduced (P less than .01) plasma P. Dietary SZA increased (P less than .02) tibia Mn, Zn, Cu, and Al. The SZA-induced increase in tibia Al was most evident in chicks fed low levels of P (SZA by P interaction, P less than .02). The overall response to dietary SZA addition paralleled the response observed from Ca supplementation, indicating that SZA increased Ca utilization, reduced P utilization, or contributed to both of these effects. These data demonstrate that the effects of SZA are influenced by the dietary concentration of Ca and P and that the addition of SZA to diets low in P results in bone Al accumulation.

Alkaline Phosphatase↗
PubMed1991

Performance of pigs with mixed nematode infections before and after ivermectin treatment.

Ninety crossbred parasitized pigs were used in two controlled experiments to compare performance before and after ivermectin treatment. Four groups of 15 pigs were sequentially infected with 2000 Ascaris suum, 10,000 Oesophagostomum spp. and 10,000 Strongyloides ransomi beginning at average pig weights of either 38 kg (Experiment I) or 14 kg (Experiment II). Two infected groups of pigs were treated with ivermectin on Day 34 (Experiment I) or 37 (Experiment II) of the experiments and all pigs were fed to slaughter weights of approximately 100 kg. Average daily gain (ADG) of heavier ivermectin-treated pigs was greater than that of infected non-treated pigs (P less than 0.03) and feed conversion was numerically greater by 5% (P greater than 0.10). ADG was not different between lighter treated or non-treated pigs, but feed conversion was numerically 4% greater in ivermectin-treated compared to non-treated pigs (P greater than 0.10). No differences existed in carcass dressing percentage among the three groups of heavier pigs, but among the lighter groups ivermectin-treated pigs had a higher dressing percentage (P less than 0.03) than infected non-treated or control pigs. Results of the calculation of production costs based on combined data from the two experiments for the post-treatment period, including feed, drug and maintenance costs, indicate that the production cost for ivermectin-treated pigs was $1.53 per pig less than that for infected non-treated pigs when the cost for each group to attain control pig weights is compared with the actual cost for control pigs.

Animals↗
PubMed1991

Effect of dietary biotin supplementation on sow reproductive performance and soundness and pig growth and mortality.

A 3-yr study was conducted to evaluate the effect of dietary biotin supplementation on the reproductive performance of 90 sows and gilts, and on the pre-weaning growth and mortality of 223 litters. Corn-soybean meal-based diets supplemented with either 0 or 440 micrograms/kg d-biotin were fed to sows throughout their reproductive cycle. Biotin supplementation had no beneficial effect (P greater than .10) on 107-d sow weight, sow weight at weaning, weaning to estrus interval, foot lesion score, hair loss score, structural soundness score, number of pigs born, number and percentage of pigs born alive or number and percentage of pigs alive at 21 d of age. Biotin supplementation had no effect (P greater than .10) on pig growth or mortality to 21 d of age. These data do not support the concept that biotin supplementation of sow diets is needed.

Animals↗
PubMed1991

Interactive effects of sodium zeolite-A and copper in growing swine: growth, and bone and tissue mineral concentrations.

An experiment was conducted with 64 crossbred pigs to determine the effect of 0 or .50% dietary sodium zeolite-A (NZA) in combination with 0 or 250 ppm supplemental Cu (as CuSO4.5H2O). Pigs were assigned randomly to one of the following four treatments: 1) corn-soybean meal basal (B), 2) B + .50% NZA, 3) B + 250 ppm Cu, or 4) B + .50% NZA + 250 ppm Cu. Each treatment was replicated four times with four pigs per replicate. Average initial weight was 7.5 kg and the experimental period lasted 144 d. Overall rate and efficiency of gain, incidence of gastric ulcers, dressing percentage, carcass weight, percentage of muscling, 10th rib fat, loin eye area, blood urea N, and bone Ca, P, Mn, Fe, Ni, Na, and Al concentrations were not affected by treatment. The addition of 250 ppm Cu increased liver (P less than .01), serum (P less than .06), and bone (P less than .07) Cu concentrations but decreased mean backfat thickness (P less than .09), bone ash percentage (P less than .03) and serum (P less than .09) and bone (P less than .01) Zn concentrations. Sodium zeolite-A increased serum alkaline phosphatase (P less than .04), carcass length (P less than .06), and liver (P less than .02) and bone (P less than .01) Zn content but decreased (P less than .04) serum Ca and serum inorganic P concentrations. Sodium zeolite-A did not protect against liver Cu accumulation or gastric ulceration in growing swine fed 250 ppm supplemental Cu.

Adipose Tissue↗
PubMed1991

Effect of dietary sodium zeolite A and graded levels of calcium on growth, plasma, and tibia characteristics of chicks.

Sodium zeolite A (SZA), a synthetic sodium aluminosilicate having high ion-exchange capacity, has been shown to increase eggshell specific gravity in laying hens and to improve Ca utilization in chickens. A 4 x 2 factorial arrangement of treatments was used to investigate the effect of dietary Ca (.6, .8, 1.0, and 1.2%) and SZA (0 and .75%) on growth, plasma, and tibia characteristics of chicks from 5 to 15 days of age. Increasing dietary Ca linearly increased (P less than .05) Ca and alkaline phosphatase (AP) in plasma and increased tibia shearing force and percentage ash, Ca, and P in tibiae. However, dietary Ca linearly decreased (P less than .05) inorganic P and Mg in plasma and Mg and Mn in tibiae. Sodium zeolite A decreased (P less than .05) plasma P and AP and tibia Mg but increased (P less than .05) tibia Ca, Zn, Al, and Mn concentrations. Tibia ash and shearing force were increased in chicks fed SZA receiving inadequate dietary Ca, but they were decreased in chicks fed SZA and excess Ca (Ca by SZA interaction, P less than .05). Tibia density showed a similar trend, but the effect was not significant (Ca by SZA interaction, P less than .12). The addition of SZA enhanced tibia ash, density, and shearing force when dietary Ca was low; however, when added to diets containing 1.2% Ca, SZA reduced many bone mineralization indices with the exception of tibia Ca.

Aluminum↗
PubMed1990

Bromocriptine-induced reduction of body fat in pigs.

An experiment was conducted with 36 crossbred finishing pigs (18 male castrates and 18 females) to evaluate the effect of bromocriptine implants on growth, feed intake, feed efficiency, plasma urea nitrogen (PUN) and carcass characteristics. Three levels of bromocriptine (0, 5 and 10 mg/[pig.d]) were administered, via implants at the base of the ear, to six (two replicates of three) male castrates or to six (two replicates of three) intact female pigs (2 x 3 factorial arrangement of treatments). Average initial weight of pigs at the time of implantation was 89.7 kg, and the implants remained in the pigs for 28 (replicate 1) or 30 (replicate 2) d prior to slaughter. Gain, feed intake and efficiency of feed utilization were not affected (P greater than .10) by bromocriptine. Plasma urea nitrogen was lower in female pigs administered 10 mg bromocriptine; bromocriptine did not affect PUN of male pigs (gender x bromocriptine, P less than .08). Tenth rib fat thickness and average backfat thickness were lower (P less than .06) and percentage of muscling was higher (P less than .06) in pigs implanted with bromocriptine. Female pigs had less 10th rib fat but larger loin eye areas and a greater percentage of muscling than male pigs.

Adipose Tissue↗
PubMed1990

Amino acid-supplemented raw soybean diets for finishing swine.

Growth and carcass traits of finishing swine fed amino acid-supplemented raw soybean (RSB) diets were examined. Experiments 1 and 2 were identical and included the following treatments: 1) corn-soybean meal (SBM), 2) corn-RSB (lysine equal to Diet 1), 3) Diet 2 + .15% L-lysine (LYS), 4) Diet 3 + .1% L-threonine (THR), 5) Diet 3 + .05% L-tryptophan (TRP), 6) Diet 3 + .15% DL-methionine (MET) and 7) Diet 3 + THR + TRP + MET equivalent to Diets 4 to 6. The unsupplemented corn-RSB diet reduced (P less than .05) gain, gain:feed, plasma urea N, loin eye area, and percentage of muscling compared with the corn-SBM diet. The addition of LYS or LYS + TRP generally improved these response variables, whereas the addition of LYS + THR or LYS + MET tended to reduce gain and gain:feed compared with the LYS addition alone. The LYS + THR + TRP + MET addition resulted in growth and carcass traits that were intermediate between those of pigs fed the corn-RSB and the corn-SBM diets but not different (P greater than .05) from either. Experiment 3 included Diets 1, 2 and 7 from Exp. 1 and 2, in addition to the following treatment: corn-RSB + LYS + THR + TRP. The LYS + THR + TRP addition improved (P less than .05) growth and carcass traits compared with the LYS + THR + TRP + MET addition.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1990

Interactive effects of sodium zeolite A (Ethacal) and monensin in uninfected and Eimeria acervulina-infected chicks.

An experiment was conducted with 5- to 18-day-old Arbor Acres broiler chicks to evaluate the interaction of sodium zeolite A (NZA) and monensin in uninfected and in coccidiosis-infected chicks. Sodium zeolite A (0 and .75%) or monensin (0 and 121 ppm), or both, were fed to uninfected chicks or to chicks infected with 4 x 10(5) sporulated, Eimeria acervulina oocysts, resulting in a 2-by-2-by-2 factorial arrangement of treatments. Coccidial infection reduced (P less than .01) weight gain, feed intake, feed efficiency, percentage of bone ash and of bone calcium; but the infection increased (P less than .05) bone Zn percentage. Monensin alleviated (or at least partially so) the adverse effects of the coccidial infection on weight gain, feed intake, feed efficiency and percentage of bone ash (coccidiosis by monensin, P less than .01). In addition, monensin increased the bone-calcium (P less than .06) and zinc content (P less than .02) in uninfected chicks and in those infected with coccidiosis. Sodium zeolite A tended to reduce feed intake by coccidiosis-infected chicks (coccidiosis by NZA, P less than .07), but increased (P less than .01) the bone zinc and decreased (P less than .01) serum inorganic phosphorus in uninfected chicks and in those infected with coccidiosis.

Aluminum Silicates↗
PubMed1989

Early embryonic development in vitro by coculture with oviductal epithelial cells in pigs.

This experiment was designed to evaluate the ability of three different somatic cell cultures to promote development of early cleavage stage pig embryos. A total of 245 2-cell, 4-cell, 8-cell, and 16-cell pig embryos were cocultured for 5 days with porcine oviductal epithelial cells (POEC), porcine fetal fibroblast monolayer (PEF), a combined POEC and PEF coculture system (PEF-POEC), or Dulbecco's Modified Eagle Medium alone (DMEM). Embryos were collected at slaughter from the reproductive tracts of superovulated prepubertal gilts. Embryos were recovered, evaluated, and randomly placed in one of the four treatment groups. POEC were recovered from oviductal flushes, washed, and placed in 24-well plates. PEF were obtained from 30-day to 60-day fetuses and established in culture. Finally, PEF-POEC consisted of a confluent monolayer of PEF in the bottom of 24-well plates also containing a Costar semipermeable membrane chamber with POEC in it. Embryos were evaluated every 24 h to determine stage of development. More (p less than 0.05) embryos developed to blastocysts in POEC (70% and 54%, respectively) and PEF-POEC (67% and 61%, respectively), than in either DMEM (16% and 2%, respectively) or PEF (27% and 23%, respectively). However, development of embryos did not differ (p less than 0.05) for POEC and PEF-POEC. These data indicate the presence of a primary culture of POEC promotes in vitro development of early cleavage stage pig embryos.

Animals↗
PubMed1989

Bromocriptine alters hormone rhythms and lipid metabolism in swine.

Hormones, metabolites and activities involved in lipid synthesis were assayed in pigs made leaner by bromocriptine treatment. Market size female swine were allowed free access to food under natural lighting conditions and implanted with bromocriptine pellets designed to release 10 mg/pig/day for 28 days in an effort to inhibit prolactin secretion. Between the 2nd and 3rd week of treatment, plasma samples were obtained from each group at 4-hour intervals throughout the day for assays of prolactin, cortisol, insulin, triglyceride, cholesterol and glucose concentrations. Twenty-eight or thirty days after the implantations, all animals were sacrificed for determinations of backfat thickness and insulin binding in the liver. At sacrifice, bromocriptine treatment reduced backfat thickness by 14% and insulin binding to partially purified hepatic membranes by 39% compared with control values. At 14 days following implantations, there were dramatic daily variations in plasma cortisol and prolactin levels in the control pigs and these rhythms were markedly altered in phase and amplitude in the bromocriptine-treated pigs. Bromocriptine reduced by 45, 20 and 13% the high levels of triglyceride, glucose, and cholesterol, respectively, that were found in control pigs near sunset. Plasma insulin concentrations did not vary during the day in control pigs and bromocriptine did not influence the insulin levels. The findings support important roles for a temporal synergism of cortisol and prolactin rhythms in maintaining hepatic lipogenic responsiveness to insulin. Bromocriptine treatment alters these hormonal relations and reduces lipid synthesis.

Animals↗
PubMed1989

Effect of fenbendazole and pyrantel tartrate on the induction of protective immunity in pigs naturally or experimentally infected with Ascaris suum.

An experiment was conducted with 96 weanling pigs (avg initial wt 18.5 kg) divided into six treatment with two replicates of eight pigs each. Pigs in Treatments 1, 2 and 3 were penned in outside pens with dirt lots that previously were contaminated with A. suum ova to induce a natural ascaris infection. Pigs in Treatments 4, 5 and 6 were penned in an open-front building with solid concrete floors and were experimentally infected with 2,000 embryonated A. suum. ova on d 1, 15 and 29 of the experiment. Pigs in Treatments 1 and 4 were medicated with fenbendazole (FBZ, 3 mg/[kg BW.d]) for three consecutive days during three consecutive time periods. Pigs in Treatments 2 and 5 were medicated with pyrantel tartrate (PT, 106 mg/kg feed) for 28 d. Pigs in Treatments 3 and 6 served as infected, unmedicated controls. All pigs were challenged with 100 A. suum eggs 7 d after termination of the final FBZ treatment. All pigs were killed 66 d after challenge and worms were recovered. Fenbendazole treatment resulted in greater (P less than .07) average daily gain than PT treatment in pigs penned outside. Among inside pigs, FBZ treatment resulted in better (P less than .02) feed utilization than in controls. The FBZ and PT treatments reduced (P less than .03) the total number of A. suum, the length and weight of female ascarids and the length of male ascarids compared with controls. A natural continual infection with A. suum was less effective than experimental infection in inducing protective immunity in pigs.

Animals↗
PubMed1989

Effect of dietary sodium zeolite A and excess calcium on growth and tibia calcium and phosphorus concentration in uninfected and Eimeria acervulina-infected chicks.

Two identical trials were conducted with 5 to 14-day-old broiler chicks. Sodium zeolite A (NZA, 0 and .75%) and Ca (1.0 and 1.5%) were fed to both uninfected and Eimeria acervulina-infected chicks resulting in a 2 x 2 x 2 factorial arrangement of treatments. Coccidial infection reduced weight gain and gain:feed (P less than .01), and tibia ash, Ca, and Ca:P ratio (P less than .05). Excess dietary Ca reduced (P less than .05) weight gain and tibia ash in uninfected chicks but had no effect (P greater than .10) in coccidiosis-infected chicks (Ca x coccidiosis interaction, P less than .05). Addition of NZA to diets with excess Ca further decreased (P less than .05) weight gain and tibia ash in both uninfected and E. acervulina-infected chicks. Tibia Ca, as a percentage of dry fat-free tibia, was reduced (P less than .05) by the addition of NZA. This effect was not observed when tibia Ca was expressed as a percentage of ash. These results suggest that NZA may exacerbate the adverse effects of excess dietary Ca.

Aluminum Silicates↗