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Biomedical subjects

L Lampé

Publications and source records attributed to L Lampé.

At least 19 recordsLinked to original sources
PubMed1992

[Importance of prognostic factors in the prognosis of cancer of the endometrium].

126 stage I and II endometrial cancer patients were followed up for at least 5 years to evaluate the impact of surgical-pathological risk factors on the survival. Out of the prognostic variables evaluated the age and clinical stage failed to influence the 5-year survival rate. The effect on survival of factors such as low grade of differentiation and the depth of myometrial infiltration was however significant, (p < 0.01 and p < 0.001 respectively). The early local recurrence has also significant negative prognostic value (p < 0.05). This latter can be effectively prevented through the prehysterectomy suture of the external cervical os. On the basis of their findings authors suggest to consider the grade and the depth of myometrial invasion beside the clinical stage at the determination of the extension of the surgical procedure and at the decision on the administration of postoperative irradiation.

Combined Modality Therapy↗
PubMed1992

[Surgical cerclage in the treatment of cervical incompetence during pregnancy (determining the legitimacy of the procedure)].

The authors studied the effectiveness of the cervical cerclage operation in the therapy of cervical insufficiency during the pregnancy. Two Hundred sixteen pregnant women took part in this trial in whose pregnancy the necessity of cerclage operation was not unequivocal. It means, that the therapeutical cerclage operation was not necessary, but the necessity of prophylactic cerclage operation was doubtful as well. From the randomized 216 cases they performed cerclage operation in 108 pregnancies and in 108 cases they did not perform it. In the respect of pregnancy care they did not make any difference between the two groups. The authors from their trial draw the conclusion, that in doubtful cases where the necessity of cervical cerclage operation is not unequivocal--e.g. at serious gestational case history--it is advisable to perform the operation. The danger of premature birth can be diminished in this way.

Female↗
PubMed1992

[The role of different committees and individuals in the ethical position on the new methods of human reproduction].

Due to the research on assisted human reproduction and the application of its results we face new type ethical dilemma which had never existed before. The traditional system of ethical values does not provide a safe basis for judgement of our actions. One of the challenging questions is who has the right to authorize or prohibit performing different procedures. There might be necessary and justifiable taking into account the opinions of various bodies (professional committees, national and institutional ethical committees, religious bodies, parliamentary representatives and private organizations or persons). The authors introduce the activities of the role and importance of these bodies and investigate the position of the research and clinical professionals in obtaining permission for the application of ethically sound or less criticizable procedures. The importance of the provision of continuous and many-sided information for wide range of the society is underlined.

Embryo Transfer↗
PubMed1990

Tissue characterization by transvaginal colour Doppler for the evaluation of gynaecological tumours. 1. Review of the literature.

This is the first review published in Hungary about the usefulness of transvaginal colour Doppler (TVCD) in gynaecology. The history of "ultrasound tissue characterization", the conventional and colour Doppler methods are discussed as well as the pathomorphological basis of abnormal Doppler signals. The summary of tumourangiogenesis, of neovascularization and its manifestation in Doppler spectrum are given. The differences between normal and pathological Doppler signals in female small pelvis are shown. It is concluded that the routine application of TVCD will reduce the rate of false positive results and "luxury" operations from screening procedures.

Female↗
PubMed1990

Tissue characterization by transvaginal colour Doppler for the evaluation of gynaecological tumours. 2. Clinical experiences.

Transvaginal colour Doppler was used to evaluate the blood flow patterns in pelvic vessels in a group of 315 patients including 168 with uterine tumours and 147 with adnexal masses. Neovascularization of malignant tumour tissue was successfully displayed by colour Doppler in the vases of endometrial and ovarian cancers but no abnormal blood supply was observed in the cases of early cervical cancers. A comparison between the characteristics of blood flow within benign and malignant lesions showed lower resistance index in cases of malignancy. The sensitivity, specifity, positive predictive value, negative predictive value and the diagnostic accuracy of this new method in the recognition of endometrial and ovarian cancers are higher than 95%. By the help of transvaginal colour Doppler (together with the classical methods as colposcopy, cytology etc.) it will be possible to establish of complex screening programmes for all types of gynaecological cancers.

Adnexal Diseases↗
PubMed1979

International cooperation to collect obstetric data.

Reported are preliminary results of an international collection of data initiated by FIGO. Data of 33.000 deliveries in 19 countries, five countries each in South America, Africa, and Asia and four in Europe provided a good basis for comparison and called attention to shortcomings in each individual country and to the need for more progress in obstetric treatment. - Sociological and demographic items in a questionnaire bring into focus the importance of both family planning and sexual education. - The authors consider this data collection a preliminary study for modernisation of Tauffer Statistics.

Africa↗
PubMed1979

[Different labour behaviours following induction, using oxytocin and prostaglandin F2 alpha (Enzaprost) (author's transl)].

The authors studied the characteristics of labour induced by means of prostaglandin (Enzaprost F). The results were compared to spontaneous childbirths and to labour induced by means of oxytocin. Increased basal tension of the uterus and higher amplitude of uterine contractions were recorded from the prostaglandin group. Contractions were also analysed for variations in shape. Deformation in response to oxytocin was found to be almost identical to that following prostaglandin. Atypical contractions were found to occur more often in women in whom labour was induced for risk to the foetus and in primiparae, though the number of third-type contractions was lower in such cases. The point is made that betamimetics may be very helpful in getting to grips with incoordinate uterine activity. They were found to stop irregular uterine activity, and re-induction then will be accompanied by regular rhythmicity of labour.

Adult↗
PubMed1978

Two modifications of the intrauterine membrane contraceptive device.

The intrauterine membrane (IUM) is an intrauterine contraceptive device designed to be compliant with a range of uterine shapes and sizes and with transient dimensional changes resulting from uterine motility. This compliance was expected to contribute to low rates for removal due to bleeding and pain, but the use of the IUM resulted in heavy bleeding among its early users. Consequently, two modifications of the device were made to decrease bleeding. One group of IUMs was modified by using ethylene vinyl acetate to provide a high level of lateral compliance and another was modified by using a tissue-compatible Hydron coating in order to decrease the inflammatory response of the endometrium. One hundred of each of these modified IUMs were tested along with 100 of the standard IUMs in a double-blind study conducted at the Noi Klinika in Debrecen, Hungary. The findings of this study suggested that these two modifications did not improve the over-all performance of the IUM.

Adult↗
PubMed1978

Menstrual regulation by mean of endometrial aspiration.

The results of menstrual regulation performed in 181 cases of supposed pregnancy are described. In 166 cases (92%) pregnancy could be interrupted without dilatation of the os uteri and only in 15 cases (8%) was it necessary to dilate the cervical canal by 8.5--9.0 H units. The majority of pregnancies was interrupted by means of vacuum aspiration and only in 15 cases was curettage performed because of a supposed residue. In the postoperative period slight blood discharge occurred in 2 cases and in 1 case the choriodecidual residue had to be removed by curettage one week after vacuum aspiration. The advantage of the method are particularly remarkable in the interruption of the first pregnancy since it can be carried out without an injury to the cervical canal.

Abortion, Induced↗
PubMed1977

The value of bed rest in twin pregnancies.

The effect of bed rest on the duration of pregnancy, the birth weight of newborns, the frequency of premature birth, and perinatal mortality was examined in 491 twin pregnancies. Cases were divided into two groups - women hospitalized from the 24th-26th week of pregnancy until delivery (rested group, 242 patients) and outpatients (unrested group, 249 patients). The premature birth rate was considerably less for patients in the rested group: in this group 41.0% of the newborns were delivered earlier than the 38th week and 42.9% of them weighed less than 2 500 g, whereas in the unrested group 75.0% were delivered earlier than the 38th week and 77.2% weighed less than 2 500 g. In addition, the perinatal mortality rates observed in the two groups were significantly different. Based on these findings, we conclude that the high premature birth rates and subsequent high perinatal mortality may be considerably reduced if twin pregnancies are diagnosed early and patients are hospitalized from the 26th week until delivery.

Bed Rest↗