Biomedical subjects
Publications and source records attributed to L Lehr.
A new method for long term cannulation of the common bile duct in dogs is reported. The procedure is carried out with a T-tube, which is brought out through the abdominal wall. There it is rolled up in the hole of an implanted Thomas cannula. - A reliable protection from removal by the animal. The result in 9 dogs was very good, the longest duration of cannulation was 9 months.
Principle and procedure of a new method in the treatment of experimental hyperbilirubinemia for removing protein-bound, not dialyzable substances from blood by extracorporeal hemoperfusion are described. In six out of eight experiments a decrease of serum bilirubin levels between 11 and 36% has been accomplished. Changes in hemograms are reported and correlations between serum bilirubin value, amount bilirubin bound by the agarose beads and bilirubin clearance rate are discussed.
The influence of jejunoileal bypass on bile salt kinetics and lithogenity of bile was investigated in 9 German shephard dogs. Total bile acid pool decreased 92% from initial values, bile acid turnover rate was enhanced markedly. High relative biliary cholesterol concentration lead to an increase of lithogenity of the bile.