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Biomedical subjects

L Matsson

Publications and source records attributed to L Matsson.

At least 37 records · Page 2Linked to original sources
PubMed1995

Periodontal conditions in Vietnamese immigrant children in Sweden.

The aim of the present study was to compare the periodontal health in Vietnamese immigrant children in Sweden with that of native Swedish children. The study groups consisted of 42 6-17-year-old Vietnamese children and 42 age- and sex-matched Swedish children. Information on systemic health was obtained by interview. Clinical examination included recordings of dental plaque, supragingival calculus, bleeding on probing, probing depth, clinical attachment loss and caries. Radiographs were evaluated for presence of marginal bone loss, proximal calculus and proximal caries. In addition, previously obtained and filed radiographs were used as a supplement in order to evaluate if the children at any time point during the ages 4-11 years had experienced proximal calculus or bone loss in the primary dentition. The Vietnamese children showed significantly higher number of sites with bleeding on probing and with probing depths > or = 4 mm. Radiographic calculus was found in 55% of the Vietnamese and in 2% of the Swedish children. 5 Vietnamese children and 1 Swedish child showed periodontal bone loss at the time of examination. In all children except 1, the bone loss was confined to primary teeth. The retrospective analysis of available radiographs from the primary dentition showed that 28% of the Vietnamese children and 5% of the Swedish children had experienced bone loss in their primary teeth during the ages 4-11 years.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1994

Oral findings in a group of newborn Swedish children.

Oral examinations were performed of 1021 newborn Swedish children, of whom 101 were re-examined after 2-3 or 4-5 months. The most common findings, registered in 74.9% of the children, were of oral mucosal cysts situated either palatally or on the alveolar ridges. The majority of the palatal cysts disappeared shortly after birth, and some alveolar cysts appeared after birth. Ankyloglossia was found in 2.5% of the children, and Fordyce spots in 1.0%. No natal teeth were found. The upper labial frenum was attached to the crest of the alveolar ridge in 76.7% of the children, palatally in 16.7% and buccally in 6.7%. The relationship of the alveolar ridges was recorded: the anterior segment of the mandibular ridge was distal to the maxillary in 99% of cases, and, posteriorly, the mandibular ridges were lingual to the maxillary in 97.6%. An open bite was found in 39.8% of the children.

Female↗
PubMed1994

Marginal bone loss in the primary dentition. A survey of 7-9-year-old children in Sweden.

The present study was designed to determine the prevalence of bone loss in the primary dentition of children. Radiographs from children aged 7-9 were collected from 25 out of a total of 26 Public Dental Clinics in the County of Orebro, Sweden. These radiographs, representing 36.0%, 50.3% and 48.7% of all 7-, 8- and 9-year-old children (n = 8666) living in the districts of the participating clinics, constituted a primary sample. In addition, the 9-year-olds were subjected to a more comprehensive sampling procedure to obtain a more complete sample (sample of 9-year-olds), resulting in a group of 2017 children (71.9%). The radiographs were evaluated with respect to presence of marginal bone loss (CEJ-MBL: distance between the cemento-enamel junction and the marginal bone level > 2 mm), proximal calculus and number of decayed and filled proximal surfaces (dfsp) in the posterior areas of the primary dentition. In the primary sample, the prevalence of bone loss for > or = 1 proximal surfaces of the primary dentition in the 7-, 8- and 9-year-old children was 2.0%, 3.1% and 4.5%, respectively. The corresponding figures for proximal calculus were 2.5%, 3.1% and 4.2%. Mean number of dfsp amounted to 2.3, 2.5 and 3.0. The prevalences of bone loss and proximal calculus as well as the mean number of dfsp in the sample of 9-year-olds corresponded to the findings for the 9-year-old children in the primary sample.(ABSTRACT TRUNCATED AT 250 WORDS)

Alveolar Bone Loss↗
PubMed1994

The plasminogen-activating system in gingival fluid from adults. An intra-individual study before and after treatment of gingivitis.

High concentrations of tissue plasminogen activator (t-PA) and placental type plasminogen activator inhibitor (PAI-2) have previously been found in gingival crevicular fluid (GCF) of adults and children. In the present study, intra-individual comparisons were made of the concentrations of t-PA, urokinase type plasminogen activator (u-PA), PAI-1, and PAI-2 in GCF from the same sites before and after periodontal treatment in eight healthy male volunteers aged 35-46 yr. The gingival state was assessed by exudate measurement, bleeding on standardized probing, and the gingival index of Löe & Silness 3 days before the start of the trial and on the day after completing a 21-day preventive program consisting of instruction and professional cleaning once a week. Eight sites per subject were selected for enzyme analyses, all showing improvement in gingival state during the period. Sampling of GCF at the start and at the end of the trial was done with small disks of Millipore-filter. t-PA and PAI-2 were analyzed with enzyme-linked immunosorbent assays with low method errors. The mean concentrations of t-PA were 0.73 mg/l before treatment and 0.49 mg/l after treatment. The mean concentrations of u-PA were 84.4 micrograms/l before treatment and 101.6 micrograms/l after treatment. PAI-1 was found in three subjects at the detection level. The mean PAI-2 concentrations were 2.19 mg/l before and 1.13 mg/l after treatment. The mean molar ratio PAs/PAI-2 was 0.47 before and 0.48 after treatment. This insignificant change implies a maintained proteolytic balance and indicates that PAI-2 is an important inhibitor of tissue proteolysis.

Adult↗
PubMed1993

Factors influencing the susceptibility to gingivitis during childhood--a review.

A variety of biological changes take place during childhood which have an impact on the development of gingival inflammatory disease. This paper reviews the literature concerning changes in the susceptibility to gingivitis during childhood. It is concluded that during certain periods the risk of developing gingivitis is relatively low, while in others the gingival tissues are more susceptible and react to bacterial irritation with inflammation. Factors that may be responsible for these changes include differences in bacterial plaque composition, in immune defence systems and in morphology of the gingival tissues, and also factors related to tooth eruption and puberty.

Adolescent↗
PubMed1993

Marginal bone loss in the primary dentition of patients with juvenile periodontitis.

118 patients with juvenile periodontitis (JP), diagnosed when the patients were 13-19 years old, were studied retrospectively with respect to radiographic marginal bone loss in the primary dentition, experienced when the patients were 5-12 years old. 168 other 13-19 year old patients without any signs of bone loss in the permanent teeth were used as a reference group. The JP patients were classified into 2 groups according to the number of sites with bone loss in the permanent dentition: JP group I having 1 site with bone loss (n = 45) and JP group II having > or = 2 sites with bone loss (n = 73). It was found that 35 patients (52%) of JP group II displayed 1 or more sites with bone loss in the primary dentition during the age of 5-12 years. The corresponding numbers for JP group I and the reference group were 9 (20%) and 8 (5%) respectively. These findings indicate that juvenile periodontitis, at least in some individuals, may have its onset already in the primary dentition.

Adolescent↗
PubMed1993

Presence of mast cells in various oral mucosal sites in juvenile and adult rats.

The present investigation was designed to study the number of mast cells in various oral mucosal sites in juvenile and adult rats, with special reference to presence of subtypes of mast cells. Fifteen juvenile (1-month-old) and 15 adult (6-month-old) rats were used. Biopsies were taken from tongue, bucca, marginal gingiva (incisor area), and intestine (jejunum). For optimal preservation of the stainability of subtypes of mast cells, a fixative with low aldehyde concentration and low pH was used. The biopsies were embedded in paraffin-wax. The first of three consecutive sections (5 mu) was stained in toluidine blue for 30 s, the second in toluidine blue for 7 days, and the third in astra blue/safranine. The total number of mast cells was represented by all cells positive to toluidine blue after 7 days' staining, or the sum of cells positive to astra blue and safranine. Cells positive to toluidine blue after 30 s were classified as connective tissue mast cells (CTMCs), and those positive after 7 days, but not after 30 s, as mucosal mast cells (MMCs). Cells positive to safranine in the astra blue/safranine staining sequence were classified as CTMCs, and those positive to astra blue as MMCs. Cells with intermediate staining characteristics in the astra blue/safranine staining sequence were recorded separately. The total number of mast cells in the tongue, buccal mucosa, and gingival mucosa was significantly higher in the juvenile than in the adult rats. In the buccal and gingival mucosa, more than twice as many mast cells were found in the young animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1993

Clinical evaluation of glass ceramic inlays (Dicor).

The purpose of the study was to evaluate the clinical behavior of ceramic class-II inlays (Dicor) in the first 2 years after placement. As a reference, a similar number of dental amalgam restorations were followed up during the same period. Twenty-five inlays and 25 dental amalgams were placed on premolars and first molars of 20 and 19 patients (15-19 years old), respectively. The inlay preparations were made in accordance with the manufacturer's recommendations, and the inlays were produced by a licensed Dicor laboratory. The inlays were luted, using a glass ionomer cement. The dental amalgam preparations were made using standard class-II preparation techniques and filled with ANA 2000. The inlays were evaluated after 6, 12, and 24 months, and the dental amalgam restorations after 24 months, using the criteria suggested by Ryge. In addition, the 24-month examination included proximal recording of dental plaque and gingivitis. With the exception of two inlays that fractured during the observation period, all ceramic inlays showed excellent ratings for anatomic form, marginal discoloration, and marginal caries at all examinations. Two inlays showed minor marginal defects but were classified within the range of acceptance with no need for replacement. The two fractured inlays were replacements of earlier fractured dental amalgams. The clinical behavior of the dental amalgam restorations was in most respects similar to that of the ceramic inlays. Unlike the inlays, however, no dental amalgams fractured during the observation period.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Local inflammatory reactions in juvenile and adult rats.

The present investigation was designed for the study of the early phases of local inflammatory reactions in juvenile and adult rats. A recently developed experimental model, based on continuous diffusion of an inflammation inducing agent, was applied. Thirty-five juvenile (6 weeks) and thirty-five adult (6 months) rats were used. Two sterile teflon tables were implanted subcutaneously on the back of each animal on each side of the midline. After three weeks, when a connective tissue capsula had developed, the tablets were replaced by one test tablet (containing lipopolysaccharide) and one fresh teflon tablet, respectively. In each group five animals were sacrificed on day 0 and fifteen animals on each of day 7 and 21. Biopsies comprising tablet and surrounding tissue were taken and exposed to routine histological treatment. The total number of cells was assessed in four defined areas in connection with each tablet. Cells classified as leukocytes were recorded separately. The analysis was performed at 1000x magnification in a light microscope. During the first seven days an increase in the number of leukocytes was seen in the tissue adjacent to the test tablets in both young and adult rats. After 21 days the number of leukocytes was still high in the adult group while in the juvenile group the number of leukocytes returned to the base-line level.

Aging↗
PubMed1992

Mast cell heterogeneity in various oral mucosal sites in the rat.

Two distinct types of mast cells are recognized in the rat: connective tissue mast cells (CTMCs), found in the peritoneal cavity, skin, tongue, etc. and mucosal mast cells (MMCs), found in the intestinal mucosa. The two subsets differ functionally and can be defined by histochemical methods. The aim here was to characterize the mast cell population in various oral mucosal sites. Biopsies were taken from the tongue, buccal mucosa, gingival mucosa and intestine (jejunum) of 20 rats. For optimal preservation of the MMCs, a fixative with low aldehyde concentration and low pH was used. The biopsies were embedded in paraffin. The first of three consecutive sections (5 microns) was stained with toluidine blue for 30 s, the second with toluidine blue for 7 days and the third with astra blue/safranine. Cells positive with toluidine blue after 30 s were classified as CTMCs, and those positive after 7 days but not after 30 s as MMCs. Cells positive to safranine in the astra blue/safranine staining sequence were classified as CTMCs and those positive to astra blue as MMCs. The total number of mast cells was similar in the superficial layers of all oral tissues studied. There were more mast cells in the deeper than in the superficial portions of the tongue. Mast cells with staining characteristics and size similar to those observed in the intestinal mucosa (MMCs) were found together with 'classical' connective tissue mast cells (CTMCs). The results suggest that the mast cell population of oral mucosal tissues of the rat contains both CTMC- and MMC-like cells.

Animals↗
PubMed1992

Marginal bone level in the normal primary dentition.

The aim of the present study was to establish the normal range for the radiographic distance between the cemento-enamel junction (CEJ) and the marginal bone level (MBL) in the primary dentition, and to relate this distance to various physiological and pathological factors. 128 children at the ages 7, 8 and 9 years took part in the study. Clinical and radiographic examinations of the mesial and distal surfaces of all primary molars and the distal surface of the primary canines were performed. The clinical examination included measurements of the amounts of plaque, bleeding on probing, probing depth and probing attachment loss. In addition, increased mobility of the primary teeth and stage of eruption of the neighbouring permanent teeth were recorded. The radiographic examination included measurements of the CEJ-MBL distance and the remaining root length. Also, exfoliating teeth, presence of proximal dentin caries, restorations and calculus were recorded from the radiographs. Associations between various explanatory variables and the CEJ-MBL distance were tested with both a chi 2 test and a variance components analysis. The mean CEJ-MBL distance for all primary tooth surfaces was 1.0 mm. Individual surfaces displayed distances ranging from 0.0-4.0 mm. Of the variables tested for association with the CEJ-MBL distance, eruption of neighbouring permanent tooth and exfoliation of neighbouring primary tooth seemed to be associated with large CEJ-MBL distances. When surfaces with these characteristics were excluded, a CEJ-MBL range of 0.0-2.0 mm was obtained.(ABSTRACT TRUNCATED AT 250 WORDS)

Alveolar Process↗
PubMed1992

Progression of approximal caries in primary molars and the effect of Duraphat treatment.

The progression of caries lesions over a 2-yr period was studied in 3-6-yr-olds. All 468 children included in the study lived in an area during 1977-85 (Malmö, Sweden) with a low fluoride concentration (0.2 ppm) in the drinking water. Radiographs were taken with a standardized periodic identical technique. Caries lesions were scored on the distal surface of the first and on the mesial surface of the second primary molars (maximum 8 per child) according to Gröndahl et al. Half of the children were treated semiannually with a fluoride varnish (Duraphat). In all, 421 surfaces with caries at baseline were available at the 1-yr examination and 369 at the 2-yr examination. After 1 yr, 34.1% of the shallow enamel lesions remained unchanged, while a progression was seen in 60.9%. 5.1% had been restored. The corresponding figures after 2 yr were 20.6, 52.1 and 27.3%. Of the deeper enamel lesions at baseline, 28.8% remained unchanged after 1 yr and 13.7% after 2 yr. Of the lesions extending into the dentin, 81.5% had been restored after 1 yr and all after 2 yr. When evaluating the effect of Duraphat, only the percentage of individuals with one or more superficial enamel lesions showing progression was determined. After 1 yr, 51.2% in the Duraphat (n = 41) and 82.8% in the control group (n = 29) showed progression (restored surfaces included). The corresponding figures after 2 yr were 66.7 (n = 42) and 91.2% (n = 34). The differences after both 1 yr and 2 yr were statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗
PubMed1991

Marginal bone loss in 16-year-old Swedish adolescents in 1975 and 1988.

The study was designed to compare the prevalence of marginal bone loss in 2 cohorts of 16-year-old adolescents, born in 1959 and 1972, respectively. Bitewing radiographs from 400 adolescents in each group were evaluated and the presence of bone loss (distance between the cemento-enamel junction and the alveolar crest greater than 2 mm), calculus, restorations and proximal dental caries were recorded. The prevalence of bone loss was 3.5% in 1975 as well as in 1988. Bone loss was found most frequently at the mesial and distal surfaces of the first maxillary molar. The prevalence of calculus was 12% in 1975 and 7% in 1988. The mean DFS for proximal surfaces was 3.1 in 1975 and 0.8 in 1988. No statistically verified dependence was found between bone loss and calculus, or bone loss and proximal caries.

Adolescent↗
PubMed1991

Proximal attachment loss in Swedish adolescents.

The present study describes periodontal conditions in 22 adolescents with proximal attachment loss greater than or equal to 2 mm (AL) and 22 matched referents without AL, all identified in a cross-sectional study of 570 16- and 18-year-old. The cases were followed for 3 years and the referents for 1 year while they were in the care of an organized dental health system. With the exception of 1 case with Morbus Hodgkin, the case and referent groups had a similar background with respect to general health and participation in the dental health program. Bleeding on probing was found at AL sites in 12 of the cases and at corresponding sites in 4 referents. 2 cases had a history of eruption disorders at the AL sites, 1 case had experienced a defective filling and 1 had a root fissure at the AL sites. At re-examinations after 1 and 3 years, 10 out of 21 earlier identified AL cases did not meet the criterion of 1 or more sites with AL greater than or equal to 2 mm. None of the cases showed progression greater than or equal to 2 mm of the lesions. In 1 case, the number of AL sites increased during the period. 4 of the cases harboured Actinobacillus actinomycetemcomitans (A.a.) at AL sites in year 1 and 3 in year 3. 8 of the cases and 4 referents had antibodies specific for A.a.-leukotoxin. The 2 most severe cases, in terms of number of sites with AL, showed bleeding at 1 or more of the AL sites, harboured A.a. at these sites and had serum titers against A.a.-leukotoxin.

Adolescent↗
PubMed1991

A new experimental model for studies of local inflammatory reactions.

The aim of the present study was to develop and evaluate a method for studies of the early phase of the local inflammatory reaction, based on continuous diffusion of an inflammatory inducing agent. 25 rats were used. Four sterile teflon tablets were implanted subcutaneously in the back of each animal. After 3 weeks, when a connective tissue capsula had formed, the tablets were replaced by two test tablets, containing 35 micrograms lipopolysaccaride, one placebo and one teflon tablet. Five rats were sacrificed on day 0, 4, 7, 14, 21, respectively, and biopsies comprising tablet and surrounding tissue were harvested and exposed to routine histologic treatment. The number of leucocytes was assessed in four defined areas adjacent to each tablet. During the first seven days an increase in the number of leucocytes was seen in the tissues adjacent to test tablets. After 14 and 21 days the number of leucocytes was still high but lower as compared to day 7. In the tissues bordering the placebo and teflon tablets only few inflammatory cells were found. The results suggest that the tested method is suitable for studies of local inflammatory reactions during a 21 day period in experimental animals.

Animals↗
PubMed1990

Gingival inflammatory reactions in children with rhinoconjunctivitis due to birch pollinosis.

The present investigation was designed to study the degree of gingival inflammation in children with rhinoconjunctivitis due to birch pollinosis. Thirty-four children, 8-17 yr of age, participated. As controls, healthy classmates of the same age and sex were chosen. Dental examination was performed on three occasions: pollen season I (Spring 1987), off-season (Autumn 1987) and pollen season II (Spring 1988). The controls were examined on one occasion, mixed with the allergic children at the off-season examination. The degree of gingival inflammation was studied by determining the gingival bleeding tendency by standardized probing. Absence or presence of dental plaque was recorded after sulcular probing. In order to compensate for differences in oral hygiene level between the participants, the bleeding/plaque ratio according to Abbas et al. was calculated. The comparisons of the bleeding/plaque ratios revealed statistically significantly higher mean ratios in the allergic children during pollen seasons compared with off-season and with the controls. The results indicate that during the pollen season, children with allergic rhinoconjunctivitis exhibit an enhanced degree of gingival inflammatory reaction.

Adolescent↗