PubMed Health⌕ Search

Biomedical subjects

L Moggi

Publications and source records attributed to L Moggi.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Lung surgery in patients over 70 years].

The Authors according to their previous experience, report on the possibility of thoracic surgery in patients older than 70 with lung cancer. Fourty-seven patients older than 70 have been operated in the period 1984-1988 for lung cancer. The Authors performed 34 lobectomy, 11 pneumonectomy, and 4 wedge resection. The mortality rate was 4.25% (2 patients). Thirty-four patients are still living (follow-up range 12-60 months). Ten patients died. The Authors report a diagnostic and therapeutic guideline for this kind of pathology.

Aged↗
PubMed1989

Ability of retinoic and ascorbic acid to interfere with the binding of benzo(a)pyrene to DNA in explants from donors with bronchial cancer.

The capability of ascorbic acid (AA) and transretinoic acid (RA) to interfere with 3H-benzo(a)pyrene [B(a)P] binding to DNA has been evaluated in cultured bronchial mucosa explants from patients with bronchial cancer. The results show that the DNA-bound 3H-B(a)P is smaller in treated cultures than in controls. To explain this finding, it is proposed that AA, acting as antioxidant, inhibits the oxidative degradation of B(a)P, and that RA, a lipophilic compound interacting with the lipid components of mixed function oxidases, could modify the activities of these enzymes. Both vitamins decrease the concentration of ultimate carcinogen metabolites, which can interact with DNA. Furthermore, the treatment with RA does not increase DNA synthesis, while AA inhibits 3H-thymidine incorporation.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

Restoration of luteinizing hormone response to naloxone in postmenopausal women by chronic administration of the antidopaminergic drug veralipride.

To determine whether antidopaminergic drug administration may modify endogenous opioid activity at the hypothalamic-pituitary level, the effects of naloxone infusion (1.6 mg/h for 4 h) on LH secretion were studied in six postmenopausal women before and after administration of the potent antidopaminergic drug veralipride for 20 days. Before veralipride administration, the naloxone infusion did not alter LH secretion. Chronic administration of veralipride resulted in a significant (P less than 0.01) decline in plasma LH levels. In addition, the naloxone infusion induced a significant (P less than 0.05) increase in plasma LH levels, which reached values similar to those before veralipride administration. These results demonstrate that in postmenopausal women the antidopaminergic drug veralipride can restore, at least in part, the activity of the endogenous opioid system. These findings suggest that endogenous opioid peptides may mediate the inhibitory effect exerted by chronic antidopaminergic drug administration on LH secretion in humans.

Adult↗
PubMed1979

[Revascularization of the deep femoral artery in arterial insufficiency of the lower limbs. Clinical aspects and immediate results].

The main indications for revascularisation of the lower limb using the deep femoral artery are explained. In aorto-iliac disease with obstruction of the superficials, an aortofemoral by-pass is created, and the distal end of the prosthesis is sutured on the point of origin of the profunda in the form of a patch. In cases where the patients's local or general condition precludes the establishment of a femoro-popliteal by-pass in femoro-popliteal disease, endoarteriectomy is performed and a patch is applied from the CFA to the first segment of the profunda. Thirty-six cases in which the method described was applied are illustrated. These are culled from a total of 144 artery reconstructions performed in 1975--77. The results (33 asymptomatic cases 6 months after surgery, equal to 91.7%) are comparable with those obtained in by-passes with patent SFA in patients with aorto-iliac obstruction. In addition, the method often makes amputation unnecessary in patients with obstruction of the subinguinal trunks only, but unable to be treated by the establishment of a femoropopliteal by-pass.

Aorta, Abdominal↗
PubMed1975

[Indications and technics of the surgical treatment in iliaco-femoral thrombophlebitis in the acute phase].

A personal technique employed in the successful resolution of a case of iliacofemoral phlebothrombosis is described. Attention is drawn to the indications for this type of operation. The technique is not traumatic and can be easily performed, particularly with the aid of a Fogarty catheter. The results obtainable as far as the prevention of lung embolism and postphlebitic syndromes are concerned are also described.

Acute Disease↗