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Biomedical subjects

L Molnár

Publications and source records attributed to L Molnár.

At least 19 recordsLinked to original sources
PubMed1995

[Bronchiolitis obliterans organizing pneumonia: survey based on two cases].

Authors offer a survey about an aspect forming a clinical entity called bronchiolitis obliterans organizing pneumonia, by two of their patients' presentation. In Case 1 the process manifested in form of a disseminated, small spotted, diffuse shadow, causing serious resting hypoxia. Diagnosis was supported by histological examination of a substance obtained by small surgical thoracotomy. Five months' therapy of Imuran and altogether 15 months' therapy of Prednisolon resulted in recovery. Second patient's symptoms and the shadow representated in the left upper lung field on chest X-ray, proposed the probability of a tumour. The lesion removed surgically, together with the left upper lobe, proved to be the clinical appearance that constitutes histologically the subject of this paper. Surgery alone resulted in definitive recovery. Disease can be proved on the basis of histological picture and it's important to sunder it primarily from bronchiolitis obliterans as well as from other interstitial pulmonary diseases.

Adult↗
PubMed1995

Beneficial vascular and metabolic effects of cobalt-ATP in spontaneously hypertensive rabbits with diffuse chronic cerebral ischaemia.

The in vivo effects of adenosine triphosphate (ATP) have not been investigated in cerebrovascular diseases. The use of the long-acting cobalt-ATP complex (Co-ATP) permits us to observe the effects of ATP without the influence of its metabolites. This study was designed to compare the effects of intravenous Co-ATP on the cerebral blood flow (CBF), polarographically detected oxygen currents (O2a), mean arterial blood pressure (MABP), heart rate, respiration rate, cerebral electrical activity, arterial blood gases, pH, and glucose in 13 normotensive (NT) rabbits to those in 14 stroke-prone spontaneously hypertensive (HT) animals. CBF was measured by the hydrogen and heat clearance methods. In response to Co-ATP, MABP decreased and CBF increased significantly in both groups. The decrease in MABP was more marked in HT rabbits, while CBF response was 25% smaller than in NT animals. The ratio of O2a to CBF diminished moderately and simultaneously with the CBF increase in NT rabbits. In HT rabbits, the decrease in O2a/CBF was larger and began when CBF response reached its maximum. We suggest that despite the restricted CBF response, long-acting ATP should still be taken into consideration as a supplementary treatment of hypertensive encephalopathy because of its beneficial effects on cerebral metabolism and hypertension.

Adenosine Triphosphate↗
PubMed1994

Malignant colorectal tumours in young adults.

The therapeutic and diagnostic problems of colorectal cancers in young adults (under the age of 40 years) are discussed, with special considerations to the unfavourable prognosis and its underlying causes. At the Department of Surgery, National Institute of Oncology, Altogether 638 patients were treated for colorectal cancer in the course of 10 years (1975-1985). From them 34 (5.2%) were younger than 40 years old. The 5-year survival of patients younger than 40 years was 38%, while that of those older than 40 years accounted for 48%. The importance of the prudence of the general practitioners is emphasized.

Adolescent↗
PubMed1994

The value of different serological tests in serotyping of Actinobacillus pleuropneumoniae strains.

Immune sera were raised in rabbits against 12 serotypes of Actinobacillus pleuropneumoniae biotype I in order to compare serological tests for simplicity and sensitivity in serotype determination. The serological tests included the tube agglutination test with and without 2-mercaptoethanol addition, the indirect haemagglutination test with and without 2-mercaptoethanol, the immunodiffusion test and the coagglutination test. All these tests proved suitable for serotype determination with the reference strains; however, cross-reactions of varying degree were observed in all of them. Owing to its simplicity, rapidity and specificity, the coagglutination test appears to be the most suitable for primary serotyping. A more definite answer to the question could be obtained by serotyping strains isolated from field cases.

Actinobacillus pleuropneumoniae↗
PubMed1992

[Hand fractures and epiphyseal injuries in childhood].

Anatomic features of the hand in childhood are presented that are responsible for the types of certain injuries. On the basis of the data in the literature and of the authors' own experience of 92 cases the main points of the diagnosis and therapy of metacarpal and phalanx fractures are summarized. The possibility of finger-replantation is also mentioned. Their statements are illustrated by their own cases. In order to recognize late growth disturbances, the necessity of the follow up is emphasized.

Bone Nails↗
PubMed1992

Effects of carbon dioxide inhalation on cerebral blood flow and oxygen tissue level in spontaneously hypertensive rabbits.

BACKGROUND AND PURPOSE: Because previous studies have yielded conflicting results, this study was designed to investigate the efficiency of cerebrovascular reactivity to carbon dioxide in hypertension associated with moderate diffuse cerebral ischemic lesions. METHODS: The effects of carbon dioxide inhalation on mean arterial blood pressure, heart and respiration rates, cerebral cortical blood flow, polarographically detected oxygen currents (oxygen availability), and cerebral electrical activity were compared in 14 spontaneously hypertensive and 16 normotensive rabbits anesthetized with urethane and alpha-chloralose. Blood flow was measured with the hydrogen clearance and thermal clearance methods. RESULTS: In the resting state the frequency of electrical activity shifted to slower components, the levels of oxygen availability and cerebral blood flow were lower (p less than 0.01), and the ratio of the two latter parameters was greater (p less than 0.01) in hypertensive rabbits than in normotensive animals. Carbon dioxide inhalation induced more marked increases in cerebral blood flow, respiration rate, and oxygen availability in hypertensive (p less than 0.01) than in normotensive (p less than 0.05) rabbits. The ratio of oxygen availability to cerebral blood flow decreased (p less than 0.01) in the former and did not change significantly in the latter group. The carbon dioxide-induced rise in blood flow was also slower and more protracted in hypertensive rabbits (p less than 0.01). Histological investigation revealed groups of neurons with ischemic changes in the cortex of the hypertensive rabbits. CONCLUSIONS: We suggest that in hypertensive rabbits the mild multiple ischemic lesions are the basis of functional disturbances, including reduced resting cerebral blood flow, greater oxygen tissue level, slower response to carbon dioxide, and greater vasodilatory capacity.

Administration, Inhalation↗
PubMed1992

[Experience with the surgical management of childhood fractures and epiphyseal injuries].

Authors analyse 1792 fractures in children, treated during 10 years in their Department and distributed in age groups. They take the part of conservative treatment of the majority, about two third, of fractures in childhood. They consider as operative indication certain forms of epiphyseal injuries, the dislocated intraarticular fractures, the unstable fractures, certain cases of polytrauma and the open fractures.

Adolescent↗
PubMed1991

Difference between the cerebrovascular effect of purinergic Co-ATP and that of the cholinesterase inhibitor, physostigmine, in vivo.

Development of the cerebrovascular effect of cobalt-ATP was compared to that of physostigmine in 34 anesthetized rabbits. The resting cortical cerebral blood flow (CBF) was estimated from the H2 clearance and the CBF changes by the heat clearance method. Systemic blood pressure, heart and respiratory rate and cerebral electrical activity were recorded simultaneously. In addition, we measured arterial glucose concentration, pH, PaO2 and PaCO2. Both drugs were found to induce a significant increase in CBF. However, the degree of the CBF increase induced by Co-ATP was inversely related, while that induced by physostigmine was directly related to both the baseline level of CBF and the value of PaCO2. We conclude that the cerebrovascular effect of ATP depends mainly on vessel tone, while the effect of physostigmine is related to the level of PaCO2.

Adenosine Triphosphate↗
PubMed1991

[Immunologic studies in myelodysplastic syndrome].

Myelodysplastic syndrome is a clonal stem-cell disease, which predominantly involves myeloid cell lines. However, several observations refer to a possible pathological condition of the lymphoid system as well. Because of these controversial data, we investigated 25 patients with MDS at our clinic. Absolute lymphocyte counts, lymphocyte subpopulations (using methods of mAT, OKT 3, 4, 8, Leu7), T and B rosette tests and quantitative tests of immunoglobulins were made possibly during diagnosis or breaks in treatment. A significant ratio of our patients had lymphopenie. Using both rosette tests or mAT methods, the ratio of T-cells (primarily of T4-cells) reduced, and the decrease of NK-cells characterized with Leu7 mAT was also marked. Polyclonal hypergammaglobulinaemia could frequently and significantly be observed during immunoglobulin identification. All the observed abnormalities were rather marked in the group of patients with excess of blasts.

Adult↗
PubMed1991

[Bronchoscopic appearance of the bronchial mucosa in pulmonary venous hypertension].

The authors studied the bronchoscopic appearance of bronchial mucosa's vessel contour in pulmonary venous hypertension in 20 patients with mitral stenosis and in 20 with cardiomyopathy and/or aortic vitium. The submucous venous congestion was scored on the base of its extent and severity according to Ohmichi. They have observed a linear relation between the PPA (wedge) and PPA values in patients with mitral stenosis and the total scores indicatory of submucous venous congestion. The mean total scores of patients with mitral stenosis as well as cardiomyopathic patients showing volume-loading of the pulmonary circuit and/or aortic vitium differed to the benefit of the former. Mucosa's vessel contour of grade 3 was found in 12 patients with mitral stenosis and only in 4 cases of cardiomyopathy and/or aortic vitium, so that is more characteristic of mitral stenosis. In spite of this, condition of patients with cardiomyopathy and/or aortic vitium are considered more severe on the base of NYHA values. Taking both patient populations into consideration relation between NYHA-phase and the degree of total scores could not have been proved. Venous congestion on lower part of the left main bronchus was observed in every patient. Appearance of congestive bronchial mucosa has not occurred in pure precapillary pulmonary hypertension.

Aortic Valve Stenosis↗
PubMed1991

[Data on possibilities of rehabilitation of lower limb amputees].

The authors investigated ways to improve the results of rehabilitation during the course of their clinical practice. During the last 2 years, amputation was performed on 136 patients and 50 patients were supplied with temporary protheses. 38 patients out of 50 answered the question form supplied. After analysis of the question form, the authors summarized the possibilities to improve the results of prolonged mobilisation and rehabilitation. This programme stresses the need for 1. early mobilisation-teaching to walk and 2. care of body and soul.

Amputees↗
PubMed1990

[T-lymphocyte subgroups and the activity of human natural killer cells in non-Hodgkin lymphoma of moderate and high malignancy].

T-lymphocyte subgroups and the percentage and the activity of Human Natural Killer cells (HNK) were investigated by the authors in their 24 patients suffering with low grade and 24 with high grade malignancies of non-Hodgkin lymphoma (NHL). According to their observations, the ratio of CD3, CD4, Leu-7, and HNK cells as well as the release by HNK cells of 51Cr bound to target cells decreased, depending on the pathological stage. The tests were performed with monoclonal antibodies. A significant change could also be observed in the reactivity of bone marrow cells to monoclonal sera, which showed complete correspondence in character with the behavior of lymphocytes isolated from peripheral blood. No significant changes could be observed in the quantitative relations of immunoglobulins. Discussing the supposed immunological relation in detail, the role of plasma factor that reduces the formation of T-lymphocytes, is assumed to have primary importance in this phenomenon.

Antibodies, Monoclonal↗
PubMed1990

[Surgical complications in colorectal tumors].

Complications of elective surgery on 510 colo-rectal cancer patients are reported. Mortality rate of the operations was 4.9% and complications were observed in 10% of the cases. Intraoperative and early postoperative (10%) as well as late (8.6%) complications have been differentiated. Causes and possibilities for preventing complications are analyzed.

Colorectal Neoplasms↗
PubMed1990

[Diagnosis and therapy of metastatic and recurrent colorectal tumors].

77 patients were treated by the authors because of recurrent or metastatic colorectal cancers. Follow-up protocol of elective surgery is discussed with respect to the two different types of surgery that is those performed because of colon and rectal cancer, respectively. The diagnostic and therapeutic principles as well as the results gained by the authors are discussed in details in case of the different types of recurrent and metastatic tumours (anastomotic recurrence, metachron tumour, local recurrence, hepatic, pulmonary, lymph node and osseal metastasis). In contrast to the previous principles a more active surgical therapy is advised by the authors in case of recurrence and metastases of colorectal cancers.

Carcinoembryonic Antigen↗
PubMed1990

Changes of T-lymphocyte-subsets and their consequences in B-CLL.

The distribution of T-lymphocyte subsets of 18 patients with lymphocytic leukaemia tested with monoclonal antibodies as well as E-rosettes formations and EAC-rosettes formations were studied. The patients classified according to RAI (stages 0-II. and III-IV.) a proportional decrease of T-lymphocytes was observed only, whereas their absolute number increased. T-lymphocyte subsets also changed: the ratio of CD4 positive lymphocytes reduce, while the proportion of CD-8 positive lymphocytes increased. The ratio of the two cell groups was below the normal value (1.8 and 1.0, respectively). This value is lower in stages III-IV., and refers to a serious immune imbalance, the latter being responsible for acute infections. The four weeks medication with Leukeran and COP resulted in unchanged rates of pathological cells with a decrease in the number of lymphocytes. These phenomena primarily refer to clonal damage of the cell line, resulting in pathological T-helper and T-suppressor functions. Owing to the relatively long lifespan of the lymphocytes, only a prolonged cytostatic treatment can yield favorable results in therapy.

Antibodies, Monoclonal↗
PubMed1990

T-lymphocyte subgroups and the activity of human natural killer (HNK) cells in low-grade and high-grade malignant cases of non-Hodgkin lymphoma.

T-lymphocyte subgroups and the percentage and activity of Human Natural Killer (HNK) cells were investigated in 24 patients suffering from low-grade and 24 patients with high-grade malignancies of non-Hodgkin lymphoma (NHL). The ratio of CD3, CD4, Leu-7, and HNK cells as well as the release by HNK cells of the 51Cr bound to target cells were found decreased, depending on the pathological stage. The tests were performed with OKT-monoclonal sera. A significant change was observed in the reactivity of bone marrow cells to monoclonal sera; the change was identical in character with that observed when lymphocytes isolated from the peripheral blood were used in the same tests. No significant changes could be observed in the quantitative relations of immunoglobulins. Such changes could by no means be expected, on the basis of the unchanged number of T-suppressor lymphocytes (CDB). As to the supposed immunological relation in detail, the role of a plasma factor that reduces T-lymphocyte formation is assumed to have primary importance in this phenomenon.

Antibodies, Monoclonal↗