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Biomedical subjects

L Molnár

Publications and source records attributed to L Molnár.

At least 37 records · Page 2Linked to original sources
PubMed1997

Effect of i.v. dipyridamole on cerebral blood flow, blood pressure, plasma adenosine and cAMP levels in rabbits.

In response to intravenous administration of dipyridamole, the quantitative and temporal changes in plasma adenosine and cyclic AMP (cAMP) levels in relation to the changes in cerebral blood flow (CBF) and mean arterial blood pressure (MABP) have not been studied. Therefore, we investigated simultaneously the changes in CBF (hydrogen and thermal clearance methods), MABP, plasma adenosine (HPLC) and cAMP (radioimmunoassay) levels for 1 h after intravenous injection of 0.7 and 1.4 mg/kg dipyridamole in rabbits. In separate experiments, only plasma adenosine concentrations were measured to determine how and for how long intravenous administration of 0.7 mg/kg dipyridamole is able to inhibit the removal of plasma adenosine. Dipyridamole decreased MABP, increased plasma adenosine and cAMP levels in a dose-dependent manner. The dose-dependency of increases in CBF could not be demonstrated owing to the marked hypotension. The increase in plasma adenosine concentrations was biphasic. The first peak could be detected at the end of the dipyridamole injection. The second peak occurred 20 min after drug administration, simultaneously with the maximal increases in plasma cAMP level and CBF, whereas the maximal fall in MABP developed earlier. Intravenous administration of 0.7 mg/kg dipyridamole inhibited adenosine uptake only by 25%, which lasted less than 10 min. We concluded that intravenously given dipyridamole is responsible only for the initial short-lasting elevation of plasma adenosine concentration, and is able to induce vasodilation without either dipyridamole itself or adenosine necessarily gaining access to the muscular layer.

Adenosine↗
PubMed1997

Neurotoxicity of paraquat and triphenyltin in the earthworm, Eisenia fetida Sav. A histo- and cytopathological study.

Neuropathological effects of the pesticides paraquat (PQ, a herbicide) and triphenyltin (TPT, a fungicide) were studied on the postclitellar segmental ganglia of juvenile E. fetida specimens using light and electron microscopic methods. Growth retardation of the worms in standard culture medium was used as quantitative marker of sublethal effect. There is a distinct neuron group in the segmental ganglia characterised by high sensitivity against PQ- and another one against TPT-toxication. However the marked histo- and neurocytopathological alterations were similar in PQ and TPT treated worms. Both chromatolysis and vacuolation of perikarya were revealed in sensitive neurons. Damaged cells were swollen and possessed degenerated rough endoplasmic reticulum cisternae. They were also characterised by swollen mitochondria, with electronlucent matrix and damaged inner membranes, and vesicular structures of various diameters as well as numerous lysosomes. Necrotic neurons with pyknotic nuclei and highly eosinophilic cytoplasm were also found in affected ganglia. Several dividing neurons were found in PQ-toxicated worms while no cell division occurred either in control or TPT-toxicated animals. The exact neurochemical and functional identification of PQ- and TPT-sensitive neurons needs further investigations.

Animals↗
PubMed1996

Sensitivity of strains of Serpulina hyodysenteriae isolated in Hungary to chemotherapeutic drugs.

The sensitivity of 332 strains of Serpulina hyodysenteriae isolated in Hungary between 1978 and 1992 was tested against seven chemotherapeutic drugs frequently used for the treatment of swine dysentery, and the changes in the patterns of resistance were also monitored. All the strains remained sensitive to carbadox, with minimum inhibitory concentrations (MIC) of only 0.05 to 0.40 microgram/ml at present. The susceptibility of the strains to dimetridazole has gradually decreased, but about half of the strains are still sensitive, with large numbers of "moderately sensitive' strains; the MIC values varied within wide limits (0.1 to 50 micrograms/ml). Most of the strains were resistant to tylosin, with MIC values from 0.1 to 100 micrograms/ml. The number of strains resistant to lincomycin has gradually increased, but about half of the strains remain sensitive; the MIC values ranged from 0.2 to 100 micrograms/ml. Recently, tiamulin has proved the most effective antibiotic, but some resistant strains have already emerged (MIC values 0.05 to 50 micrograms/ml). Monensin was good for the prevention of swine dysentery, but resistance may evolve quickly; the MIC values ranged from 0.4 to 25 micrograms/ml. For sedecamycin, the MIC values (6.25 to 100 micrograms/ml) were much higher than expected.

Animals↗
PubMed1996

[Social and behavioral factors influencing caries intensity and oral hygiene in an adult population in Budapest (sociological implications of a dental-sociological survey)].

Authors examined 868, 15-69 age old, non-selected patients. The findings of dental aspects of the investigation were reported in this periodical (88, 95-112, 1995). The sociological analysis verified strong connection between oral status and social stratification. The authors found that differences in oral status on the basis of educational qualification are larger than the differences on the basis of occupations. The effects of social factors on oral health behaviour are stronger than on oral status. The authors found strong connection between patients' oral health behaviour and parents motivations for patients' body culture.

Adult↗
PubMed1995

[Bronchiolitis obliterans organizing pneumonia: survey based on two cases].

Authors offer a survey about an aspect forming a clinical entity called bronchiolitis obliterans organizing pneumonia, by two of their patients' presentation. In Case 1 the process manifested in form of a disseminated, small spotted, diffuse shadow, causing serious resting hypoxia. Diagnosis was supported by histological examination of a substance obtained by small surgical thoracotomy. Five months' therapy of Imuran and altogether 15 months' therapy of Prednisolon resulted in recovery. Second patient's symptoms and the shadow representated in the left upper lung field on chest X-ray, proposed the probability of a tumour. The lesion removed surgically, together with the left upper lobe, proved to be the clinical appearance that constitutes histologically the subject of this paper. Surgery alone resulted in definitive recovery. Disease can be proved on the basis of histological picture and it's important to sunder it primarily from bronchiolitis obliterans as well as from other interstitial pulmonary diseases.

Adult↗
PubMed1995

Beneficial vascular and metabolic effects of cobalt-ATP in spontaneously hypertensive rabbits with diffuse chronic cerebral ischaemia.

The in vivo effects of adenosine triphosphate (ATP) have not been investigated in cerebrovascular diseases. The use of the long-acting cobalt-ATP complex (Co-ATP) permits us to observe the effects of ATP without the influence of its metabolites. This study was designed to compare the effects of intravenous Co-ATP on the cerebral blood flow (CBF), polarographically detected oxygen currents (O2a), mean arterial blood pressure (MABP), heart rate, respiration rate, cerebral electrical activity, arterial blood gases, pH, and glucose in 13 normotensive (NT) rabbits to those in 14 stroke-prone spontaneously hypertensive (HT) animals. CBF was measured by the hydrogen and heat clearance methods. In response to Co-ATP, MABP decreased and CBF increased significantly in both groups. The decrease in MABP was more marked in HT rabbits, while CBF response was 25% smaller than in NT animals. The ratio of O2a to CBF diminished moderately and simultaneously with the CBF increase in NT rabbits. In HT rabbits, the decrease in O2a/CBF was larger and began when CBF response reached its maximum. We suggest that despite the restricted CBF response, long-acting ATP should still be taken into consideration as a supplementary treatment of hypertensive encephalopathy because of its beneficial effects on cerebral metabolism and hypertension.

Adenosine Triphosphate↗
PubMed1995

[Caries intensity and oral hygiene in adult dental patients in Budapest].

Authors examined 868, 15-69 age old, non-selected patients. DMF-T scores were between 7.8 and 24.69, DMF-S scores were between 14.78 and 67.39. Both data increased according to the age of the patients. The scores of the Periodontal Index (PI) were between 0.47 and 1.32, and the scores of the OHI-S between 1.10 and 1.59. Among those patients, who were non-smokers, and regularly visited their dentist, better dental status and oral hygiene could be observed.

Adolescent↗
PubMed1994

Malignant colorectal tumours in young adults.

The therapeutic and diagnostic problems of colorectal cancers in young adults (under the age of 40 years) are discussed, with special considerations to the unfavourable prognosis and its underlying causes. At the Department of Surgery, National Institute of Oncology, Altogether 638 patients were treated for colorectal cancer in the course of 10 years (1975-1985). From them 34 (5.2%) were younger than 40 years old. The 5-year survival of patients younger than 40 years was 38%, while that of those older than 40 years accounted for 48%. The importance of the prudence of the general practitioners is emphasized.

Adolescent↗
PubMed1994

The value of different serological tests in serotyping of Actinobacillus pleuropneumoniae strains.

Immune sera were raised in rabbits against 12 serotypes of Actinobacillus pleuropneumoniae biotype I in order to compare serological tests for simplicity and sensitivity in serotype determination. The serological tests included the tube agglutination test with and without 2-mercaptoethanol addition, the indirect haemagglutination test with and without 2-mercaptoethanol, the immunodiffusion test and the coagglutination test. All these tests proved suitable for serotype determination with the reference strains; however, cross-reactions of varying degree were observed in all of them. Owing to its simplicity, rapidity and specificity, the coagglutination test appears to be the most suitable for primary serotyping. A more definite answer to the question could be obtained by serotyping strains isolated from field cases.

Actinobacillus pleuropneumoniae↗
PubMed1994

[Dental status of 14-18-year old secondary school students in Budapest (VIII. District) in 1991. (Implications of a dental-sociological study)].

In this dento-sociological examination the dental status of 1623 secondary-school-students living in the capital of Hungary, was found better than that of the same-aged students examined previously. The number of decayed teeth was higher than the number of filled teeth. The average level of oral hygiene was found between "good" and "middle" levels. Among the three types of secondary schools the best oral hygiene status was found in the secondary grammar school.

Adolescent↗
PubMed1993

[Aspiration of barium contrast medium and its prevention].

The authors have been noted aspiration bronchograms associated with barium-filling study of the upper gastrointestinal tract in 58 patients involving basal medial, anterior, lateral and posterior segments of the lower pulmonary lobes, mammary segment of the middle lobe, moreover inferior lingula. In 75.9% of patients (44 cases) the barium meal got to bilateral basal medial, anterior and lateral segments. The 34 men and 24 women had a mean age of 69 years (range, 29-88 years). The aspiration was found 3.8-times more frequent after completion of patient's 50th year than before it observed. A transient tertiary mobility disorder of the esophagus, extrasystoles and tendency for collapse were on barium-filling of bronchi. In 15 of the 18 patients the Valsalva's maneuver proved a pharyngomyodystonia. Carrying out of endoradiography depended on function of the lateral pharyngeal wall. The bronchi with physiological saline following aspiration of the contrast medium within 30 minutes were lavaged.

Adult↗
PubMed1993

Effects of dipyridamole in spontaneously hypertensive rabbits with diffuse chronic cerebral ischemia.

The effect of intravenous dipyridamole (0.7 mg/kg) on cerebral blood flow (CBF), mean arterial blood pressure (MABP), heart rate, respiration rate, cerebral electrical activity, arterial blood gases, pH, and glucose was investigated in 14 normotensive and 14 stroke-prone spontaneously hypertensive anesthetized rabbits. CBF was measured by hydrogen and heat clearance. In both groups, MABP decreased (normotensive: -24 mm Hg, hypertensive: -47 mm Hg; ANOVA: P < 0.0001) and CBF increased (normotensive: +59 ml/100 g/min, hypertensive: +72 ml/100 g/min; ANOVA: P < 0.0002). CBF returned to the initial level 21 min later in hypertensive than in normotensive rabbits. Changes in other parameters were insignificant. In additional experiments, 30 mg/kg theophylline entirely prevented the cerebral vasodilator and systemic hypotensive effects of dipyridamole in both normotensive and hypertensive rabbits. We conclude that, in stroke-prone spontaneously hypertensive rabbits, the longer-lasting and larger CBF increase in response to dipyridamole may be attributed to reversible functional changes in the cerebral vasculature resulting from hypertension.

Analysis of Variance↗
PubMed1993

[Breast-preserving operations in surgically treatable breast cancer].

Since 1980, based on international experience, breast conserving operations have been introduced at the Surgical Department, in the National Oncological Institute, Budapest. In 12 years, out of 4622 primary breast cancer operations, 1055 breast preserving interventions were carried out. For all patients adjuvant radiotherapy was indicated. In lymph node positive premenopausal cases chemo-radio-chemotherapy, for postmenopausal patients radiotherapy with tamoxifen has been provided. The first 604 patients (10 years) have been evaluated and 489 of them could be followed. The mean follow-up time was 49 months. During this period of time metastases have developed in 61 patients (12.5%); 26 (5.3%) of them died with the disease. Local recurrences occurred in 29 patients (5.9%). For small recurrences reexcision, for the others mastectomy or/and radiotherapy was carried out. Critical evaluation of the local recurrences was done.

Adult↗
PubMed1993

[The effect of breach presentation on the development of the hips].

Authors examined, using sonographic methods in 100 children with breech-presentation, which of the intrauterine postures means a major danger in the development of hip dysplasia. It was found that acetabular alterations, requiring therapy or not, develop more frequently in groups in which the hips were in total flexion, the knees in semiflexion and the lower extremities in major external rotation. Based on their results they state that not the simple breech position is the greatest danger in the development of dysplasia and dislocation in babies born with breech presentation.

Breech Presentation↗
PubMed1992

[Hand fractures and epiphyseal injuries in childhood].

Anatomic features of the hand in childhood are presented that are responsible for the types of certain injuries. On the basis of the data in the literature and of the authors' own experience of 92 cases the main points of the diagnosis and therapy of metacarpal and phalanx fractures are summarized. The possibility of finger-replantation is also mentioned. Their statements are illustrated by their own cases. In order to recognize late growth disturbances, the necessity of the follow up is emphasized.

Bone Nails↗