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Biomedical subjects

L Montebugnoli

Publications and source records attributed to L Montebugnoli.

69 records · Page 4Linked to original sources
PubMed1981

Intralymphocytic sodium concentration: a sensitive index to identify young subjects at risk of hypertension.

In subjects with borderline (BL) hypertension and in normal subjects with familial hypertension (FH), the increase in diastolic blood pressure (DBP) induced by mental arithmetic, handgrip and bicycle exercise strongly correlates with intralymphocytic sodium concentration (ILSC). In BL subjects with high or normal ILSC basal BP values are identical, but the increase in DBP during stress is significantly greater in BL subjects with high ILSC. The same phenomenon can be found in normal subjects with FH. Four hours after acute salt loading urinary Na+ is significantly higher in BL subjects with high ILSC. ILSC is a test by which one can identify BL and normal subjects with abnormal responsiveness to stimuli and who probably are fated to develop sustained hypertension.

Adolescent↗
PubMed1979

Intralymphocytic sodium in hypertensive patients: a significant correlation.

1. Intralymphocytic sodium concentration was measured in 50 patients with essential stable hypertension, 44 patients with labile hypertension and 40 subjects with normal blood pressure. 2. Intralymphocytic sodium concentration in normotensive subjects was significantly lower than in the other two groups. 3. The concentration was significantly correlated with mean blood pressure in the group as a whole and in the groups with stable and with labile hypertension. No correlation was found in normal subjects.

Blood Pressure↗
PubMedDate not supplied

Effects of moderate salt restriction on intralymphocytic sodium and pressor response to stress in borderline hypertension.

The effects of a moderate dietary salt restriction on intralymphocytic sodium content and pressor response to stress (mental arithmetic, handgrip, and bicycle exercise) were tested in 25 young subjects with borderline hypertension. The study was performed by a randomized, cross-over, within-patient, experimental design. Diet did not significantly reduce blood pressure at rest but did so significantly in both systolic and diastolic blood pressure during stress and exercise. Variations in diastolic blood pressure induced by stimulation correlated significantly with intralymphocytic sodium content both before and during low-salt diet whereas no correlation was found in the case of systolic blood pressure and heart rate variations. These findings suggest that in young subjects with borderline hypertension, sodium homeostasis and blood pressure regulation are somehow interrelated, and that a moderate dietary salt restriction reduces both intralymphocytic sodium content and pressor response to adrenergic stimulation. This could be useful in preventing the development of sustained hypertension.

Adolescent↗
PubMedDate not supplied

Anti-HCV antibodies are detectable in the gingival crevicular fluid of HCV positive subjects.

AIMS: To verify the possible of identifying HCV-positive subjects by assaying hepatitis C immunological markers in the gingival crevicular fluid. METHODS: Ten HCV-EIA-positive subjects and ten HCV-EIA negative subjects were enrolled. One specimen each of blood, saliva and gingival crevicular fluid were collected from each subjects, and anti-HCV antibodies determined using a rapid test described elsewhere. RESULTS: The test was highly sensitive and specific (100%) on whole blood, but unable to detect anti-HCV antibodies in any specimen on whole saliva; anti-HCV antibodies were detected in about 80% of gingival crevicular fluid specimens from HCV-positive subjects, suggesting that the HCV virus and anti-HCV antibodies may enter the pounth in the gingival crevicular fluid and then spread outside the mouth via the saliva. CONCLUSIONS: The gingival crevicular fluid could be a valid alternative to blood for detection of HCV-positive subjects; in association with the HCV rapid test this may be a useful procedure for use in routine dental practice.

Enzyme-Linked Immunosorbent Assay↗
PubMedDate not supplied

[Evaluation of cardiovascular response to stress in dental patients].

The purpose of this study was to record some clinical and psychological parameters in attempt to find out and to estimate patients with abnormal cardiovascular responses during dental therapy. On the basis of psychological questionnaires, used to value anxiety, resulted that patients who have self defined themselves anxious and therefore objectively nervous while in the dental chair, underwent cardiovascular responses significantly lower than those who were not anxious. Among the clinical parameters studied, blood pressure and the heart rate during basic conditions are not able to foresee hemodynamic responses during dental extraction. The only clinical situation able to relate to a corresponding regularity with an hemodynamic response during dental extraction, is the blood pressure determination during a provoked generic mental stress. These findings suggest that cardiovascular response during dental stress depends on the personal individual reaction of each individual.

Adolescent↗
PubMedDate not supplied

[Evaluation of cardiac function in dentists during professional activity].

In this study research was carried out a comparison between different dental situations by using a common parameter: myocardial oxygen consumption, accurately expressed in terms of cardiac exercise. Important increase in the previously specified parameter in dentists were provocated by dental extractions conducted on anxious patients. Tooth extractions undertaken on calm and cooperative patients determined an increase of cardiac exercise in dentists similar to those caused by amalgam restoration conducted on a manikin, but not in ergonomic work conditions. The situation, referred previously, resulted more stressing for the dentist, as regard to a similar restoration conducted, this time, in ergonomic work conditions. Amalgam restoration performed on calm and cooperative patients caused alterations of cardiac exercise as referred previously to those provocated by a similar restoration conducted on a manikin in ergonomic conditions. These findings show that work conditions and patients anxiety have a negative influence on the dentists' cardiovascular apparatus. The corrisponding poor modification of the oxygen consumption in the whole organism demonstrates that major part of cardiac exercise is dissipated by stress.

Anxiety↗