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Biomedical subjects

L N Filippenko

Publications and source records attributed to L N Filippenko.

22 records · Page 2Linked to original sources
PubMed1977

[State of the surface activity of pulmonary surfactant in rats at different periods after left-sided pneumonectomy].

The surface activity of the seven-fold washing of the right lung was measured on the modified Wilhelmy's balance after the leftside pneumonectomy in rats. It appeared to be normal (gamma min-23--24 dynes/cm) up to the 5th day, and at the remote postoperative periods. The intracellular edema of the air-blood barrier components and the release of the edema fluid into the alveolar lumen in the "vesicle" composition failed to influence the surface properties of the lung surfactant. A sharp increase of the alveolar dimensions on the 5th--7th postoperative day was followed by an increase of the surface-active properties of the lung washings (gamma-min-11--15 dynes/cm) and by the intensified secretion of the material of the osmiophilic lamellar bodies from the alveolar cells of the 2nd type into the alveolar lumen. The cytological mechanisms providing the intensified production of the surfactant in the hypertrophic alveoli are activation of the lipid synthesis in the alveolar cells of the 2nd type, their hypertrophy, and also the appearance of binuclear cells.

Animals↗
PubMed1977

[Participation of pulmonary macrophages in regulating the quantity of surfactant on the alveolar surface].

The fixation of the rat lung by perfusion through the pulmonary artery permits to prevent the "washing out" of macrophages into the alveolar lumen and to preserve their natural disposition in the hypophase of the alveolar lining layer beneath the surfactant film. The surfactant synthesis was enhanced in the granular alveolar cells (type II) of the remaining lung 5 to 7 days after the leftside pneumonectomy; the amount of the tubular myelin in the hypophase of the hypertrophic alveoli increased, and the surface tension of the lung washings diminished. At that period the alveolar macrophage count more than doubled. The alveolar macrophages utilized the excess of surfactant (the tubular myelin) in the hypertrophic lungs, thereby taking part in the regulation of the alveolar surface tension.

Animals↗
PubMed1975

[The state of the "glycocalyx" of rat lung cells following left-sided pneumonectomy].

Edema in the tissue of the right lung developed 24 hours after the leftsided pneumonectomy. It was found that: 1) the layer of acid mucopolysaccharide on the surface of the alveolar and endothelial cells became thicker; 2) accumulation of the product of reaction with the RR on the surface of the alveolar cells of type 1 and of the endothelial cells took place; 3) "blisters" coated with the product of reaction with the RR (Red Ruthenium) appeared. These "blisters" were connected with the plasmolemma of the alveolar and endothelial cells. All these findings suggest that acid mucopolysaccharides of the lung surfactant system participated in the accumulation and elimination of the water from the tissues of the air-blood barrier.

Animals↗