Biomedical subjects

L Ozzello

Publications and source records attributed to L Ozzello.

52 records · Page 3Linked to original sources

PubMed1976

In vitro synthesis of immunoglobulins and other proteins by dysplastic and neoplastic human mammary tissues.

The synthesis of several proteins in human mammary carcinomas and in dysplastic breast tissues was studied by tissue culture and by immunofluorescence. The synthesis of immunoglobulins showed marked quantitative and qualitative variations from one specimen to another, and a preferential synthesis of immunoglobulin G and C'3 in the carcinomas with lymphocytic infiltration. Fixation of immunoglobulins G and M on the surface of neoplastic cells was noted in some carcinomas. Secretory component was detectable in some cases by immunofluorescence, but no synthesis could be found in vitro, presumably because of unfavorable culture conditions. The synthesis of lactoferrin, casein, and some serum alpha- and beta-globulins was significantly greater in noncancerous tissues than in carcinomas. Synthesis of lactoferrin was also more frequent in the well differentiated carcinomas than in the poorly differentiated carcinomas. The tissue culture technique used in this study, although in need of better adaptation to the requirements in vitro of human mammary tissues, proved to be a useful tool for investigating the synthesis of several protein components by the epithelial cells of cancerous and dysplastic tissues of the human breast. Whether a preferential synthesis of 1 class of immunoglobulins or of other proteins might influence the evolution of a mammary lesion could not be determined in this material but it should be studied further.

Alpha-Globulins↗

PubMed1975

[Malignant tumors of the anal canal and the anal margin].

81 patients with tumors of the anal canal and anal margin treated at the Cantonal Hospital, Lausanne, during the period January 1942 to June 1974 have been studied. The morbid anatomy of transitional zone and cloacogenic carcinomas, subdivided into basaloid types, is related to the anatomy and histology of the normal anal canal. The average age of the patients was 66.5 years. The incidence of canal tumors was highest in women (71% of cases), but tumors of the anal margin were most frequent in men (75% of cases). The main symptom of anal canal growths in this series of advanced cases was blood on the feces; marginal tumours were associated with anal aching. Cloacogenic carcinomas of the basaloid type have the best prognosis; this is also related to the volume and invasion rate of the tumor, which are features difficult to assess. Melanomas have the worst prognosis; leiomyomas may grow like sarcomas despite their benign histological appearance. 18 patients had inguinal metastases, and only 2 of these are alive 2 1/2 and 3 1/2 years after excision of the rectum; the volume and histological type of the tumor were unrelated to the poor rate of survival. In the light of this experience, rectal amputation is the most effective prodecure for all canal tumors and for most tumors of the margin. Radiotherapy by itself is associated with an unacceptably high risk of actinic proctitis.

Adult↗

PubMed1975

[Endobrachyesophagus and adenocarcinoma].

During 6168 esophagoscopies (ENT Clinic, Medical School of Lausanne and Hospital of Yverdon: 1963-1974), 164 cylindrical epithelial patches (26%) have been detected endoscopically with a regular progressive incidence from year to year (optical improvement, interest and progressive training of endoscopists). Endoscopically, a distinction can be drawn between: 1. the cylindrical epithelial islets of the upper (19%) or lower (4%) esophagus; 2. widespread cylindrical epithelial lining of the lower esophagus (77%). The first type cannot be associated in any significant manner with any organic pathology. It is of congenital origin and is, as a rule, without pathological significance. Statistically, however, the second type would seem to enter into the category of peptic esophagitis in its chronic form, and appears to constitute a form of cicatrization. The incidence of adenocarcinoma of the lower esophagus in association with this second form of cylindrical epithelial lining is significant. It would, therefore, be advisable for peptic esophagitis to be treated before it reaches its chronic stage and, in particular, before the appearance of cylindrical epithelial scars.

Adenocarcinoma↗

PubMed1975

Columnar-lined lower esophagus: an acquired lesion with malignant predisposition. Report on 140 cases of Barrett's esophagus with 12 adenocarcinomas.

The analysis of a series of 1,225 cases of reflux esophagitis shows the serious nature of this condition. A liberal use of antireflux operations therefore seems justified. Extensive columnar metaplasia of the distal esophagus, or columnar-lined lower esophagus (CLLE), represents a late irreversible stage of reflux esophagitis. Repeated esophagoscopies demonstrate the acquired nature of the lesion. It is caused by the progressive healing, from below upward, of peptic ulcerations on the squamous epithelium by metaplasia of columnar mucosa. Antireflux operations stop the progressive ascent of heterotopic epithelium and thus stabilize reflux esophagitis and cure complications such as ulcerations and strictures. The premalignant character of this condition is established by a 10 per cent incidence of adenocarcinomas in a series of 140 cases of extensive columnar metaplasia. The transition toward malignancy seems to be irreversible and cannot be arrested by an antireflux operation. Therefore, repeated esophagoscopic controls and biopsies are an absolute necessity in all cases of extensive columnar metaplasia, even after cure of active reflux esophagitis by Nissen fundoplication.

Adenocarcinoma↗

PubMed1974