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Biomedical subjects

L Parks

Publications and source records attributed to L Parks.

6 recordsLinked to original sources

Muscular endurance and wheelchair propulsion in children with cerebral palsy or myelomeningocele.

Bivariate correlations between muscular endurance or resistance used during six-repetition maximum (6-RM) for eight upper body exercises (shoulder flexion, extension, abduction, internal and external rotation, elbow flexion, extension and shoulder flexion/elbow extension (bench press), 50-meter dash, and 12-minute wheelchair propulsion tests were examined in six children with diagnoses of cerebral palsy or myelomeningocele. Correlations were determined before and after resistance training. Before training, only elbow extension correlated significantly with the 12-minute test. Following training, significant correlations (p less than or equal to 0.05) were found between all 6-RM exercises and 12-minute test scores. Additionally, significant correlations were found between all 6-RM exercises (except elbow flexion, which approached significance) and 50-meter dash scores. The results of this clinical case investigation indicate that the relationship between muscular endurance (6-RM) and wheelchair propulsion improves as muscular endurance increases.

Adolescent

Stimulation of peripheral blood T cells by an activated T-cell line: a novel human autologous T-T lymphocyte reaction.

T lymphocyte interactions have generally been described between discrete functional subsets. In our investigation of murine T-cell interactions we described a type of T-T interaction termed the 'Syngeneic T-T Lymphocyte Reaction' in which activated T-cell clones stimulated the proliferation of resting T cells mainly through a mechanism involving cell to cell contact. To investigate whether similar reactions occur in the human immune system we used the human autoreactive T-cell line C.1 to stimulate peripheral T cells. Line C.1 cells, which are not transformed and do not secrete IL2, consistently caused proliferation of purified freshly isolated autologous peripheral human T cells as measured by a [3H]-thymidine incorporation assay. The proliferation was seen in both the CD4 and CD8 subsets and could be inhibited with anti-DR and anti-CD2 antibodies. The stimulation is not due to carryover of classical antigen-presenting cells or to the C.1 line cells acting as antigen-presenting cells. We propose that some activated T cells, probably by expression of a surface molecule, can stimulate resting T cells thereby allowing for antigen-non-specific augmentation of the immune response.

Antigens, Differentiation, T-Lymphocyte

Temporary vascular bypass for perfusion of a renal transplant during abdominal aneurysmectomy.

A temporary vascular bypass was utilized to maintain perfusion of a renal transplant during abdominal aortic aneurysmectomy. The shunt, of polyvinyl tubing, was placed between the upper abdominal aorta and the common iliac artery, where the perfusion pressure was only 15 mm Hg less than systemic pressure. The transplanted kidney fuctioned normally during 71 minutes of aortic cross clamping, and there was no evidence of postoperative renal failure.

Aorta, Abdominal

[Thoracic pain].

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Aortic Diseases