Lymphoepithelial lesions formed by lymphoma cell infiltration of the solid cell nests of the thyroid gland.
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Aged↗
Biomedical subjects
L Plank
Publications and source records attributed to L Plank.
[Histocytopathology of monocytoid B-lymphocytic lymphoma].
It is generally accepted, that the cells of non-Hodgkin's lymphomas represent a neoplastic counterpart of corresponding reactive cells. The aim of this study was to compare histocytology of 6 cases of monocytoid B-cell lymphoma (MBCL) with that of reactive monocytoid B-cells of "common" and large cell type. All the lymphomas were diagnosed in peripheral lymph nodes by histology and immunohistochemistry. Histocytological appearance of MBCL corresponded mostly to that of "common typ" MBLy (n=5) with. signs of plasmacytic differentiation (p = 3/5) or rarely (n=1) with increase of intermingled blast cells. Rebiopsy of one of the cases of the "common" cell type showed a progression to a large cell high grade lymphoma of the appearance similar to the large cell type of reactive MBCs. It is therefore to be accepted that the cells of MBCL including its high grade transformation might represent neoplastic counterparts of the reactive MBLy of the "common" and large cell type respectively.
Biopsy↗
[Second (consultation) evaluation of hematopathologic biopsies and its rules].
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Biopsy↗
Monocytoid B-cell reaction associated with peripheral T-cell lymphomas.
Benign monocytoid B-cells (MBCs) proliferation was reported to occur in various lymphoproliferative disorders, but not in peripheral T-cell lymphomas (PTCL). In our review of fifty three nodal-based, low and high grade PTCL, MBCs were identified histologically and immunohistochemically in eight of the cases. They included: chronic lymphocytic leukaemia of T-cell type (n = 1) with multiple MBCs clusters, large cell anaplastic lymphoma (n = 1) showing lymphoma cells within multiple MBCs foci, and PTCL of angioimmunoblastic lymphadenopathy (AILD) type (n = 6) with solitary (n = 4) or multifocal (n = 2) MBCs reaction. Progression from AILD-hyperimmune reaction to PTCL of AILD type could be observed in one case by three consecutive follow-up biopsies. While MBCs proliferation associated with hyperimmune reaction was prominent, in PTCL of AILD type only isolated or small multiple clusters of MBCs were present. In PTCL of AILD type, MBCs seemed to be a residual component of a prior hyperimmune reaction diminishing with progress of the disease. Therefore we assume that the development of PTCL of AILD type from preceding hyperimmune reaction is more common than previously considered. Cytologically, MBCs proliferation associated with PTCL shows two cell types, as described in reactive lymphadenopathies: the common type and the large cell type MBCs.
Adult↗
Reactive versus neoplastic monocytoid B-cell proliferations. In situ hybridization study of immunoglobulin light chain mRNA.
To distinguish reactive versus neoplastic monocytoid B-cell (MBC) proliferations, the clonality of MBC was examined in paraffin-embedded tissues by in situ hybridization (ISH) of immunoglobulin (Ig) light chain messenger RNA (mRNA) with sensitive oligonucleotide probes in 26 cases. They included 13 cases of lymphadenitis with MBC reaction and 13 cases of nodal (n = 8) and extranodal (n = 5) monocytoid B-cell lymphoma (MBCL). Two cases represented a composite lymphoma showing a centroblastic-centrocytic and MBCL component. The clonality of MBC infiltrates could be demonstrated in 16 of 26 (61.5%) cases by immunostaining for Ig light chains and in all (100%) cases by ISH. Neoplastic MBC usually expressed a faint-to-moderate light chain restriction of mRNA, whereas some MBC (10% to 30% of total MBCL population) showed a strong positivity irrespective of plasmacytoid differentiation as indicated by Ig immunostaining (present in 9 of 13 cases). Reactive MBC expressed a faint kappa and lambda light-chain mRNA positivity. Five percent to 20% of total reactive MBC showed also a strong positivity for both Ig light chain mRNA, although only a minor part of these cells (7 of 13 cases) expressed polyclonal Ig by immunohistochemistry. These results indicate that (1) both reactive and neoplastic MBC can differentiate into plasma cells; and (2) a relatively high percentage of reactive and neoplastic MBC show a detectable mRNA transcription, but not a corresponding Ig synthesis. Either the Ig detection is not sensitive enough or these cells might be in an early differentiation phase, where the Ig production has not yet started.
Adolescent↗
Phaeohyphomycosis caused by Alternaria species and Phaeosclera dematioides Sigler, Tsuneda and Carmichael.
A case of phaeohyphomycosis caused by strains of both Alternaria spp. and Phaeosclera dematioides is presented. First clinical signs of mycosis appeared on the patient's face, after an injury with a straw stalk during the wheat harvest in Germany in 1942. Further signs developed in 1955 at one forearm, and again in 1968 in the mouth, leading to perforation of the palate. After treatment with amphotericin B (1973-75) she went into a 13-year-long, clinically asymptomatic remission. She relapsed in 1988, when eight foci of the disease developed, mostly on both forearms. Diabetes mellitus and asthma developed at this time. After pulse therapy with itraconazole the patient remains in a good clinical condition.
Aged↗
[Monocytoid B-lymphocyte lymphoma: a new type within the spectrum of non-Hodgkin's B-cell lymphoma].
BACKGROUND: Clonal proliferation of monocytoid B-lymphocytes (MBLy)--monocytoid B-cell lymphoma (MBCL) represents a "new" type of lymphoma within the spectrum of B-cell malignancies. OBJECTIVES: The aim of the study was to evaluate the possibilities of a routine histological and immunohistochemical diagnosis of MBCL. METHODS: Three cases of MBCL diagnosed in peripheral lymph nodes (n = 2) and in mammary gland with infiltration of regional lymph node (n = 1) were analyzed both histologically and immunohistochemically using a panel approach (Ig chains, CD30 antigen, markers of B-cells, T-cells and of monocytes/histiocytes). RESULTS: Morphological appearance of neoplastic cells of MBCL is identical to that of MBLy in reactive conditions--kidney-shaped nuclei, bright clear PAS-negative cytoplasm, and small inconspicuous nucleoli. CONCLUSIONS: Morphological appearance together with immunophenotypic results (positivity of CD20 and Ki-B5, negativity of CD3, CD43, CD45RO, and of lysozyme, negativity of CD30) are considered to represent sufficient diagnostic criteria of MBCL, including its differential diagnosis of other B-cell low grade malignancies. An increase of large cell type MBLy might represent a feature of a secondary blastic transformation of MBCL. (Tab. 2, Fig. 5, Ref. 27.)
Aged↗
[Morphologic study of mastocytes from skin biopsies in patients with non-systemic and systemic mastocytosis].
The authors describe morphologic changes in mastocytes in the picture of transmission electron microscopy (TEM) and skin changes in patients with urticaria pigmentosa (7 causes) and systemic mastocytosis (2 causes). The presented study analyzes the changes in the cellular membrane and cytoplasmic processes, intracytoplasmic membrane structures, mitochondria, granules, and nuclei of mastocytes in patients with systemic mastocytosis. The authors evaluate these cells as being atypical, respectively immature. The study discusses the malignization of these states. (Tab. 2, Fig. 8, Ref. 16.)
Biopsy↗
Monocytoid B-cells occurring in Hodgkin's disease.
In contrast with various forms of lymphadenitis, the presence of reactive monocytoid B-cells (MBCs) has only rarely been reported in Hodgkin's disease (HD). In order to analyse their occurrence in HD, we reviewed 120 cases before or after treatment. MBCs were identified morphologically and immunohistochemically in 8 cases (nodular paragranuloma, n = 2; nodular sclerosis, n = 2; and interfollicular mixed cellularity HD, n = 4). Acute toxoplasmic, cytomegalovirus, or Epstein-Barr virus (EBV) infections were excluded by serological tests and immunohistochemistry. MBCs were negative by immunostaining for EBV encoded latent membrane protein, while Sternberg-Reed and Hodgkin's cells expressed positivity in 50% of cases. MBCs were only identified in cases with partial or incomplete lymph node infiltration by HD together with an activated B-zone of residual non-infiltrated tissue. The relation of MBCs and HD infiltrates followed three distinct patterns: large HD infiltrates without any connection to MBC foci; small areas containing various numbers of Sternberg-Reed and Hodgkin's cells at the border between MBC foci and surrounding lymphoid tissue; and HD infiltrates within at least some MBC clusters. The data obtained suggest that MBCs occurring in HD represent a transient phenomenon associated with a B-zone activation irrespective of treatment and that they are usually not histogenetically related to HD.
Antibodies↗
Monoclonal cytoplasmic immunoglobulin and pathomorphological reactions in lymph nodes in spontaneous bovine leukemia virus infection.
Prescapular lymph nodes from 109 cows seropositive to bovine leukemia virus (BLV) were examined for the presence of light chains of bovine immunoglobulin (Ig) kappa or lambda. A variety of reactions were present in prescapular lymph nodes, including B-zonal hyperplasia (23 cases, 21.1%), T-zonal hyperplasia (52 cases, 47.7%), mixed hyperplasia (18 cases, 16.5%), pulp proliferation (six cases, 5.5%), and atrophy (ten cases, 9.2%). In the case of pulp proliferation the immunohistological examination identified only Ig of a single light chain type lambda. The possible relationship of a monoclonal expression of Ig and development of tumorous proliferation is discussed in the study.
Animals↗
Generalized melanosis with malignant melanoma metastasizing to skin--a pathological study with S-100 protein and HMB-45.
A patient with primary malignant melanoma localized to the right gluteal region is described. Four years later and after intercurrent influenza, disseminated metastases of malignant melanoma to the skin occurred. After a further 6 months melanodermia developed and lasted until the death of the patient (6 months later). Autopsy revealed melanosis of the visceral organs. Histology taken from internal organs using S-100 protein and HMB-45 melanoma methods confirmed metastases of malignant melanoma to the skin, oral cavity, palatal tonsils, nasal and nasopharyngeal mucosae, lungs, myocardium and brain. The authors discuss the mechanism of melanosis--a rare sign in patients with metastasizing malignant melanoma.
Buttocks↗
The cytological spectrum of the monocytoid B-cell reaction: recognition of its large cell type.
To analyse the cytological features of benign monocytoid B-cells, we investigated, histologically and immunohistochemically, 78 reactive lymphadenopathies expressing monocytoid B-cell reactions. Within a broad cytological spectrum of reactive monocytoid B-cells, two cytological types can be recognized: 1 the common type composed of medium-sized cells with irregular or bean-shaped nuclei and inconspicuous nucleoli, and 2 the large cell type composed of cells considered to represent large transformed monocytoid B-cells, with less pleomorphic round nuclei with vesicular chromatin and moderately basophilic, prominent nucleoli. In between these variants transitional forms showing evolution to large transformed monocytoid B-cells occurred. While monocytoid B-cell reactions in 70.5% of all cases were composed predominantly of the common type of monocytoid B-cells, in 29.5% of cases the large transformed cells prevailed. The two distinctive cytological types of reactive monocytoid B-cells seem to have their neoplastic counterparts in monocytoid B-cell lymphoma, including its large cell variant.
Antigens, Differentiation, B-Lymphocyte↗
Pathomorphological and immunohistological changes in lymph nodes of cows spontaneously infected by bovine leukaemia virus.
Prescapular lymph nodes from 109 cows seropositive to bovine leukaemia virus (BLV) were subjected to histologic, cytochemical and in dubious cases also to immunohistologic examination for the presence of light chains of bovine immunoglobulin (Ig) kappa or lambda. By their morphological features, the histologically detected changes were divided into B-zonal hyperplasia (23 cases, 21.1%), T-zonal hyperplasia (52 cases, 47.7%), pulp proliferation (6 cases, 5.5%), hyperplasia of mixed type (18 cases, 16.5%), and atrophy (10 cases, 9.2%). Some changes resembled those reported in infections with human or feline immunodeficiency virus. Eosinophilic infiltration was a frequent feature. Immunohistochemical examination revealed only a lambda Ig chain in the cytoplasm of plasma cells or plasmacytoid cells and immunoblasts in pulp proliferation. Cytochemical examination showed a considerable number of cells with a diffuse positive reaction to acid phosphatase (AP).
Animals↗
[Does short-term high-frequency jet ventilation damage the tracheobronchial mucosa?].
In anesthetized rabbits, the occurrence of histopathological changes was studied above below and the level of the endotracheal tube opening after one-hour high-frequency jet ventilation (f = 150.min-1,Pin = 70-90 kPa, Ti = 0.5) with nonhumidified air and oxygen mixture (FiO2 = 0.6). The findings were compared with those obtained in intact rabbits and in rabbits which were inhaling nonhumidified air from the environment spontaneously via the endotracheal tube. Mechanical obstruction of the airways by mucus or necrosis of the mucous membrane was not observed. The major histopathological changes characteristic of inflammation and mechanical damage of the mucosa were recorded above the opening of the endotracheal tube. Towards the main bronchi the degree of the injury was decreasing. (Tab. 2, Fig. 2, Ref. 11.)
Animals↗
A study of possible causal relations between squamous cell carcinoma of the penis and carcinoma of the cervix uteri.
The authors investigated 26 regular sexual female partners of 24 men with squamous cell carcinoma of the penis. Neoplasms were diagnosed in 6 (23.1%) of the total of 26 women. STDs were found in 6 (23.1%) women. In 2 the cytologic findings on the cervix were classified as PAP III (PAP IIIa-CIN I, PAP IIIb-CIN III). Squamous cell carcinoma of the uterine cervix was found in 2 women (1 case PAP IV-CIN III; 1 case PAP V-suggestive of invasive carcinoma). Endometrial adenoacanthoma, mammary adenocarcinoma, squamous cell carcinoma of the right hand and non-Hodgkin's malignant lymphoma (centroblastic) were found in 1 case each.
Adult↗
Squamous cell carcinoma of the penis. Analysis of 24 cases.
The authors evaluated retrospectively 24 cases of spinocellular carcinoma of the penis, trying to detect aetiological carcinogenic factors of the disease. Phimosis persisting since childhood was reported by ten men, whereby in five of them circumcision was performed during puberty. The duration of symptoms up to the time of biopsy and histological verification of differentiated spinocellular carcinoma of the penis varied from one month to thirteen years. Eight patients (33.3%) belonged to category T1, 8 (33.3%) to T2 and 8 (33.3%) to T3. Fifteen tumours (62.5%) were G1, 5 (20.8%) G2 and 4 (16.7%) G3. In 5 men print cytology was negative.
Carcinoma, Squamous Cell↗
[Syncytial variant of the nodular sclerosing type of Hodgkin's disease in cervical lymph nodes with simultaneous sarcoidosis-like granulomatosis in the intrathoracic lymph nodes and liver].
A woman aged 31 years had been afflicted with mediastinal lymph node enlargement and hepatopathy for two years. Epithelioid-cell granulomatosis was diagnosed at another institute on the basis of biopsies taken from the liver and thoracic lymph nodes, resulting in the differential diagnosis of sarcoidosis or tuberculosis. Another biopsy was taken from enlarged cervical lymph nodes, after tuberculostatic therapy had remained unsuccessful and had not prevented deterioration of the patient's condition. We diagnosed from that biopsy the syncytial variant of nodular sclerosis of Hodgkin's disease. Immunohistochemically, the tumour cells exhibited positive reactions to antigens CD 15 and CD 30, whereas no evidence was provided to the presence of cytokeratins, lysozyme and S-100 protein. In grading, we associated our case with subtype 2 of nodular sclerosis and clinical stage II. Combined radiotherapy and chemotherapy resulted in complete remission of the tumour disease. Presence of granulomatosis similar to sarcoidosis was confirmed by follow-up examination of the liver and lymph node biopsies which originally had been histopathologically examined at another institute. The question is discussed whether or not this granulomatous reaction reflected an increased immunological defence reaction of the organism to Hodgkin's disease and thus offered an explanation for the unexpected favourable course of the patient's disease.
Adult↗