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Biomedical subjects

L Plavoşin

Publications and source records attributed to L Plavoşin.

At least 19 recordsLinked to original sources
PubMed1976

[The action of the vaccinia virus upon placenta and fetus in revaccinated pregnants (author's transl)].

We studied 608 antivariolic revaccinated pregnants in spring 1972 at different ages of gestation. 60 presented spontaneous abortus; in 502 cases there has been performed therapeutical abortion, and 46 pregnants revaccinated after 2 1/2-3 months of gestation continued their pregnancy. Pregnancy and birth in revaccinated pregnants which did not abort, evolved without any difference against the witness-sample; the newborns presented in a higher percentage underweight. The absence of the vaccinia-virus and of Guarnieri-inclusions in the examined placentae and embryos as well as the moment of abortion, only after 20 days from the revaccination data, leads to the supposition that the placental lesions do not seem to be produced by the direct action of the virus by its replication, but probably by reactions of hypersensibility of the late type against the alergizin antigens of the antismallpox vaccine. The antivariolic revaccination of the sample of pregnants, showed that the vaccinia virus did not present a malformative action upon the embryo, but in change the abortive action was manifest in indirect proportion to the age of gestation.

Abortion, Spontaneous↗
PubMed1975

The influence of smallpox revaccination upon the foetus.

Serological, virological, anatomo- and histopathological investigations were performed in pregnant women subjected to smallpox revaccination. Serological findings were normal; no vaccinia virus was isolated from 210 placentae collected upon therapeutical abortion. Anatomopathological investigation of 15 placentae showed various lesions, while the embryo were free from any histopathological changes. The data prove that smallpox immunization does not affect the embryo directly, but only through the placenta.

Adult↗
PubMedDate not supplied

Investigations on allergic and serological reactions following inoculation of inactivated smallpox vaccines by cutaneous scarification.

A number of 154 young adults were given a smallpox vaccine inactivated by UV (103 subjects) or by 4degrees/00 formol (51 subjects). Inoculation induced an early cutaneous reaction in 75.4% of the revaccinated subjects. The incidence of positive HAI reactions in this group increased from 30.2% before vaccination to 63.8% after inoculation, while the geometric mean titer increased from 2.88 to 10.73. This would prove the early reactions to be allergic responses of organisms sensitized against smallpox vaccine, capable of stimulating antibody formation. No cutaneous reaction was recorded in the 7 persons vaccinated for the first time (without pre-existent cutaneous scars). These subjects developed neither cutaneous nor humoral response to the killed virus, as there was no previous sensitization to the respective antigen.

Adult↗
PubMedDate not supplied

Transmission of vaccinia virus from vaccinated milkers to cattle.

An infection of cattle by transmission of vaccinia virus from milkers vaccinated against small pox is reported. Six vaccinia virus strains could be isolated from the vaccinal lesions localized on the nipples of the udder. Serological reactions with samples collected from diseased cows demonstrated the presence of HAI antibodies and made evident their kinetics at a 2-week-interval.

Agricultural Workers' Diseases↗
PubMedDate not supplied

Rotavirus infection in gastroenteritis in children.

The electron microscopic investigation of biological materials (faeces, intestinal mucous biopsies) from 19 children and sucklings with clinically diagnosed acute gastroenteritis evidenced the presence of some rotavirus-like viral particles in 31 percent of cases. The age of hospitalized subjects varied between 4 months and three years. There have been identified viral particles in the cytoplasm of enterocytes of the intestinal villi and in suspensions of the fecal materials.

Child, Preschool↗
PubMedDate not supplied

[Coronaviruses in pathology].

The crown-like projections on the surface of the particles permits differentiation of coronaviruses from other riboviruses and their individualization as a distinct family. Recognition of their role in the aetiology of respiratory, enteral and encephalitic infections has promoted investigations for the finding of preventive vaccines. Selection of the strains showed that their immunogenicity depends upon the density and salience of the crown-like projections, the antigenic relationship of the projections determining cross serologic reactions between different species. At present experiments are being carried out on animals with vaccines prepared with antigenically related heterologous cornavirus species, not pathogenic for the host, and with subunitary vaccines prepared from the projections of the homologous species. The Coronaviridae family established on morphologic criteria is thus confirmed by the immunologic relationship and specificity of its members.

Animals↗